Sermorelin, GHRH Analogue to Stimulate The Pituitary Gland Directly To Increase HGH

There seems to be a type of amino acid combination that has been developed which you can take orally to stimulate the pituitary gland to increase the amount and rate of HGH that will go through the system. From what we are seeing, it is most effective for people who are suffering from growth hormone deficiency. It is known as Sermorelin Therapy, which is a type of GHRH analogue.

It would work primarily for prepubertal children with idiopathic growth hormone deficiency. The method and dosage for use is recommended from source 1 to be “subcutaneous sermorelin 30 μg/kg bodyweight per day, given as continuous infusion or as 3 divided doses”. However, the increase in height still seems to be less than just taking somatotropin once a day.

From source 2, “Unlike recombinant hGH, which stimulates production of the bioactive hormone IGF-1 from the liver, SERMORELIN simulates the patient’s own pituitary gland by binding to specific receptors that increase production and secretion of endogenous hGH” and “Its effects are regulated at the level of the pituitary gland by negative feedback and by release of somatostatin so that the side effects of too much hGH are difficult if not impossible to achieve”. Remember that the anterior part of the pituitary releases two major chemicals, somatostatin and HGH, which have inhibitory effects on the other’s influence on the body’ physiological processes. Using sermorelin means that you are not going to develop medical conditions since any increase in HGH to a level that is bad for the body would cause the release of somatostatin as well to negate the effects of the stimulated HGH.

This is the only type of treatment that is commercially available right now.

Refer to source 1 and source 2 for more information


2 thoughts on “Sermorelin, GHRH Analogue to Stimulate The Pituitary Gland Directly To Increase HGH

  1. Rep

    Does Sermorelin have similar effects to an individual as that of a peptide, or is Sermorelin weaker due to is being taken orally?

  2. Trev0r

    There is a simililar oral compound named MK-677 or Ibutamoren, which also shows GH secreting properties. A friend of mine who’s in his early 20s was planning on running it for a year, I’ll have to go see him sometime soon and report back on any physical changes.


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