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Glucosamine and Chondroitin may contribute to height by slowing down growth plate senescence

This study attempts to accelerate growth plate senescence by removing rat ovaries.  Chondroitin and Glucosamine appear to counteract the effects of senesence on growth plate fusion.  So even if say hypothetically GS+Chondroitin may do nothing normally, when growth plate is close to senesence or cessation of growth GS+Chondroitin may extend this period to be longer allowing height to grow further.  Unfortunately, they do not measure longitudinal bone growth directly.

But Glucosamine+Chondroitin is available for sale and the potential toxicity for the supplement seems to be extremely low so I consider it worth trying if growth plates appear close to fusion.

Glucosamine and chondroitin sulfate association increases tibial epiphyseal growth plate proliferation and bone formation in ovariectomized rats

“The growth plate consists of organized hyaline cartilage and serves as a scaffold for endochondral ossification, a process that mediates longitudinal bone growth. Based on evidence showing that the oral administration of glucosamine sulfate (GS) and/or chondroitin sulfate (CS) is clinically valuable for the treatment of compromised articular cartilage, the current study evaluated the effects of these molecules on the tibial epiphyseal growth plate in female rats.

The animals were divided into two control groups, including vehicle treatment for 45 days (GC45) and 60 days (GC60) and six ovariectomized (OVX) groups, including vehicle treatment for 45 days (GV45), GS for 45 days (GE45GS), GS+CS for 45 days (GE45GS+CS), vehicle for 60 days (GV60), GS for 60 days (GE60GS) and GS+CS for 60 days (GE60GS+CS). At the end of treatment, the tibias were dissected, decalcified and processed for paraffin embedding.

Notably, after 60 days of treatment, the number of proliferative chondrocytes increased two-fold, the percentage of remaining cartilage increased four-fold and the percentage of trabecular bone increased three-fold in comparison to the control animals.

GS and CS treatment drugs led to marked cellular proliferation of the growth plate and bone formation, showing that drug targeting of the tibial epiphyseal growth plate promoted longitudinal bone growth.”

An OVX female mice is a mice that has had their ovaries removed and this is used to simulate osteoperosis.  So there’s guarantee that this will be applicable to a healthy individual.  The rats in this study were 16-weeks old.

The control OVX groups in this study had disorganized growth plates and reduced growth plate size.

OVX growth plates +- CS

“Growth plate photomicrographs of the following: A – non-OVX rats treated for 45 days with vehicle (GC45); B – OVX rats treated for 45 days with vehicle (GV45); C – non-OVX rats treated for 60 days with vehicle (GC60); D – OVX rats treated for 60 days with vehicle (GV60), E – OVX rats treated for 45 days with GS (GE45GS); F – OVX rats treated for 45 days with GS+CS (GE45GS+CS); G – OVX rats treated for 60 days with GS (GE60GS); and H – OVX rats treated for 60 days with GS+CS (GE60GS+CS). Sirius red-hematoxylin staining. (r: resting cartilage; p: proliferative cartilage; h: hypertrophic cartilage, c: remaining cartilage, o: trabecular bone, m: bone marrow). Scale bar = 75 µm.”

Here’s an LSJL growth plate for reference from this LSJL study:

The mice in this study were not OVX and were 8 weeks old.  The growth plates do not appear to be more disorganized.

“Compared to GV45 and GV60, the GE45GS, GE45GS+CS, GE60GS and GE60GS+CS groups presented an organized cellular arrangement and increases in the number of resting and proliferative chondrocytes, PZ thickness, remaining cartilage and the trabecular bone area. In addition, these groups showed a decrease in the number of hypertrophic chondrocytes in the bone marrow area, as well as a decrease in RZ and HZ thickness.”

The GC45 and GC60 are the control groups were looking at since those are the control groups that are not OVX.  They will help answer the question if Chondroitin and Glucosamine stimulated growth beyond just eliminating the deficit caused by OVX.  Compared to control, Chondroitin and Glucosamine treated OVX rats had more resting and proliferative chondrocytes and less hypertrophic chondrocyes.  So CS+GS may inhibit chondrocyte hypertrophy.

Cartilage thickness was about equal total but the CS+GS OVX group had more thickness in the proliferative zone.  CS+GS OVX group had more hyaluronan in the hypertrophic zone and after 60 days had more remaining cartilage but less bone marrow than the control group.

“In older rats, the growth plate structure and thickness is maintained but is not functional and longitudinal growth ceases at a certain point”

“To accelerate the senescence process in adult animals, OVX was performed in our study.”

 

 

Sermorelin, GHRH Analogue to Stimulate The Pituitary Gland Directly To Increase HGH

There seems to be a type of amino acid combination that has been developed which you can take orally to stimulate the pituitary gland to increase the amount and rate of HGH that will go through the system. From what we are seeing, it is most effective for people who are suffering from growth hormone deficiency. It is known as Sermorelin Therapy, which is a type of GHRH analogue.

It would work primarily for prepubertal children with idiopathic growth hormone deficiency. The method and dosage for use is recommended from source 1 to be “subcutaneous sermorelin 30 μg/kg bodyweight per day, given as continuous infusion or as 3 divided doses”. However, the increase in height still seems to be less than just taking somatotropin once a day.

From source 2, “Unlike recombinant hGH, which stimulates production of the bioactive hormone IGF-1 from the liver, SERMORELIN simulates the patient’s own pituitary gland by binding to specific receptors that increase production and secretion of endogenous hGH” and “Its effects are regulated at the level of the pituitary gland by negative feedback and by release of somatostatin so that the side effects of too much hGH are difficult if not impossible to achieve”. Remember that the anterior part of the pituitary releases two major chemicals, somatostatin and HGH, which have inhibitory effects on the other’s influence on the body’ physiological processes. Using sermorelin means that you are not going to develop medical conditions since any increase in HGH to a level that is bad for the body would cause the release of somatostatin as well to negate the effects of the stimulated HGH.

This is the only type of treatment that is commercially available right now.

Refer to source 1 and source 2 for more information

 

Kobe Bryant’s Bone Broth Diet Regime Reveals Something Critical

The recent news of the aging NBA start Kobe Bryant on consuming bone broth is making headlines and this has only a very limited appeal to most readers. I personally found it very interesting, and it seems to be related to a few personal theories I have had since starting the research. However, I wanted to go deeper into the technical details on why one of the most recognizable professional athletes in the world would be doing this in the recommendation of his nutritionist.

Note: I also talked about Kobe’s willingness to go to Germany to get the Regenokine PRP type therapy from Dr. Peter Wehling to advance the speed of his knees healing. This was mentioned by Terrell Owens in an interview. The PRP (platelet rich protein) therapy is similar to this bone broth, which is always to reduce inflammation. The body’s natural defense mechanism using the inflammation causing cytokines is what hurting our joints when we lead an over-active lifestyle.

Apparently a Dr. Kate Shanahan, nutritionist of the LA Lakers team recommended this bone broth idea to Kobe. Kobe, being the competitor that he is is willing to ingest almost anything to stay at his level of athletic ability. So what does a high-level nutritionist understand about Bone Broth that we in the general society does not?

Let me take a swing at her reasoning.

In the American Diet, people have been focused almost exclusively on what is known as “white meat”, which is very lean. White meat is what the American diet focuses on. However, the dark meat is actually where the real nutrition is at. Chicken breast is white meat. Chicken wing is dark meat. Duck meat has a similar texture and flavor as dark meat. When you are only looking at the protein density levels, then clearly white meat comes out on top. However, if you are trying to get some very unique minerals into your system, dark meat is where it is at.

Americans (and many others in the Western countries) are too focused on muscle tissue, and building muscle tissue. There is too few people who are focused on cartilage tissue. All those weight lifters, body builders, and strong man in those bodybuilding internet forums are all focused on building muscle tissue. All those fitness magazines that you find at your local shopping store is focused over and over again on how to gain muscles, but almost never talk about joints, cartilage, and bones. When I see pictures of muscle freaks like Flex Wheeler and Ronnie Coleman, I can’t help but wonder why a large percentage of the American male wants to look like these guys. The reason is most likely because we can’t control our cartilage and bone sizes and shape, unlike our muscles, which can be exercised into the shape and size that we desire.

Something that the Asian cuisine like Vietnamese, Filipino, and Chinese have done is focus almost exclusively on dark meat, since dark meat has more flavor. When I lived in South Korea for a couple years, there was a dish known as PIg Feet (jokbal) which was slices of fat and collagen along with lean meat, which gave the overall food a unique texture. That means that these Asian cultures have a tradition of eating strange things like insects, bones, and other non-western traditional proteins sources. The flavor and texture of strange meats is usually a good indicator that it is also packed with minerals and vitamins which you just don’t find in the American diet, which focus too much on lean “white” meat.

I personally love Pho, the vietnamese noodle dish, and something recently that has been added to the local menu at the restaurant down my home is Ox Tail Pho. With the ox tail, you can’t eat the source of soup base, since it is mostly bone. The reason why the Ox Trail soup/pho is used is because of its unique stronger flavor of cow meat. Eating the traditional flank, and brisket beef does not allow a person trying the soup to get the real essence of the meat.

Not only that, when you drink the soup from cow bones, you are getting collagen type I and type III, which is supposed to be really good for human skin.

Most anti-aging creams that is sold today tries to remove wrinkles in one of two ways. You can either tighten the skin, using a combination of Hyaluronic Acid and Vitamin C, thus pullng the skin around the wrinkle flatter. Or, you can fill up the grooves that make the wrinkles using a serum of Collagen combination (Type I and III). Some anti-aging marketers have gone so far as to say that ingesting collagen pills will make the skin smoother, which has not been validated.

This is why the bone broth is supposed to be so effective. It is a combination of collagen and minerals that is supposed to help the layer of articular cartilage in kobe’s knees.

I would suspect something else that the nutritionist chose not to reveal. I am guessing based on my research that it is not just cow bones that are simmered in water. The bones are also cut sideways so that the contents of the bone marrow is also getting into the soup. Remember, in the adult human, we have the intermedullary cavity, which is where adipose derived yellow type mesenchymal stem cells are, as well as other types of hemotopoietic stem cells are located. Throughout the human life, the bone marrow is still generating new osteoblasts to coat the inside of the long bones. This is known as endogenous appositional bone growth. Since the cow (and pig) are mammals like humans then it would make sense that the marrow in a cow leg does the same thing, so maybe what Kobe is swallowing is cooked progenitor stem cell content. Of course, boiling organic live cells in water for a long time would destroy all cells but the minerals are still left intact.

Something I would also like to counter with is that there might not be enough evidence that drinking bone broth would ever help a young child from developing better bones or grow taller though. The Chinese, Filipino, Iranian and Vietnamese culture all have dishes which call for the contents of the bone marrow to go into soup. However, these ethnicities have traditionally had the shortest people compared to other nations. The bone marrow derived broth may have articular cartilage helpful effects, but those health benefits don’t seem to translate to helping younger kids grow taller. Is it possible that the primary spongiosa of the growth plate in vietnamese children are just not able to get the level of magnesium and iron to make the general vietnamese population taller compared to other nations?

It might be that the soup that goes into The Vietnamese Pho may not have the high enough nutrient level, but instead is for enhancing flavor. Is it possible that the recipe of bone broth that is made specifically for Kobe has a very strong level of flavor from high nutrient levels?

Just because a athlete superstar swears by a new diet doesn’t mean that it actually helps him. I am sure with his money, he has many other forms of rehabilitation processes that he does to help his aging knee cartilage. For example, the anti-gravity treadmill. It almost completely negates the amount of weight above the waist while still allowing the runner to work their leg muscles without putting too much load on their knee joint.

The bone broth in theory does have some possibility that they do help him.

New paper that provides insight on baseball players longer arms

It’s been stated empirically that baseball players have longer throwing arms than non-throwing arms.

The following study suggests that baseball actually hinders growth in the growth plate in adolescents.  Now this could mean that either what the scientist interpret as growth hinderence is actually growth stimulation or that the baseball players having longer arms is not related to the growth plate at all and is longitudinal bone growth by other means which would be very promising for adult longitudinal bone growth.

Cartilage degeneration at symptomatic persistent olecranon physis in adolescent baseball players.

“Elbow overuse injuries are common in adolescent baseball players, but symptomatic persistent olecranon physis is rare, and its pathogenesis remains unclear. Purpose. To examine the histopathological and imaging findings of advanced persistent olecranon physis. Methods. The olecranon physes of 2 baseball pitchers, aged 14 and 15 years,{only two players were analyzed so perhaps the damage to the growth plate was an outlier.  There’s also selection bias where they likely sought out those who had injury.} were examined by preoperative magnetic resonance imaging (MRI), and surgical specimens were examined histologically. Results. T2-weighted MRI revealed alterations in the intrachondral signal intensity possibly related to collagen degeneration and increased free water content. Histological findings of specimens stained with hematoxylin-eosin showed complete disorganization of the cartilage structure, hypocellularity, chondrocyte cluster formation, and moderately reduced staining. All these findings are hallmarks of osteoarthritis and are suggestive of cartilage degeneration. Conclusion. Growth plate degeneration was evident in advanced cases of symptomatic persistent olecranon physis. These findings contribute to understanding the pathogenesis of this disease.”

I wasn’t able to copy and paste the image but if you at figure 2 you can examine the following:

“Figure 2: (a) Growth plate remnant with a sclerotic margin. Moderate reduction in hematoxylin-eosin staining and disorientation of chondron columns in the olecranon physis. (b) Magnified view showing a decreased number of chondrocytes in the lesion. (c) Chondrocyte cluster formation in the lesion. (d) Proliferating cell nuclear antigen-positive cells in a chondrocyte cluster. Bars: 200 μm (a), 100 μm (b), 50 μm (c), and 20 μm (d).”

The key factor is whether these athletes throwing arm had stunted growth.  Unfortunately, I couldn’t find any long term studies on this.  And I couldn’t find any studies that show whether moderate pitching without overuse increases growth plate disorganization.

Does anyone know of anyone with elbow overuse due to pitching and whether it stunted growth in their dominant arm?

Compressive Loading and the Growth Plate

A lot of interesting stuff here:

In vivo dynamic loading reduces bone growth without histomorphometric changes of the growth plate

“This in vivo study aimed at investigating the effects of dynamic compression on the growth plate. Rats (28 days old) were divided into three dynamically loaded groups, compared with two groups (control, sham). A device was implanted on the 6th and 8th caudal vertebrae for 15 days. Controls (n = 4) did not undergo surgery. Shams (n = 4) were operated but not loaded. Dynamic groups had sinusoidal compression with a mean value of 0.2 MPa: 1.0 Hz and ±0.06 MPa (group a, n = 4); 0.1 Hz and ±0.2 MPa (group b, n = 4); 1.0 Hz and ±0.14 MPa (group c, n = 3). Growth rates (µm/day) of dynamic groups (a) and (b) were lower than shams. Growth plate heights, hypertrophic cell heights and proliferative cell counts per column did not change in dynamic (a) and (b) groups compared with shams. Rats from dynamic group (c) had repeated inflammations damaging tissues; consequently, their analysis was unachievable. Increasing magnitude or frequency leads to growth reduction without histomorphometric changes. However, the combined augmentation of magnitude and frequency alter drastically growth plate integrity. Appropriate loading parameters could be leveraged for developing novel growth modulation implants to treat skeletal deformities.”

“Three main factors contributing to bone growth are cellular enlargement in the hypertrophic zone (40–50%), matrix synthesis (35–45%) and cell duplication in the proliferative zone (10%).”

“different frequencies and magnitudes of the dynamic loading applied for 10 min per day in rats forelimbs, and found that growth was reduced proportionally to load magnitude and not the average load.”<-Magnitude is the peak load.  So the peak load you obtain with say LSJL has the largest impact on the stimulus.  Note that the loads advocated here are compressive loads rather than the more tensile load of LSJL.

“among dynamic parameters, we suggest that frequency has more impact on growth compared to magnitude.”<-It’s a lot harder to modulate frequency than magnitude with LSJL.

Dynamic Compressive Loading decreased growth in the Cd7 vertebrae.  Produced a minor growth rate reduction on Cd5.  However, it increased growth rate on CD9 so the various disc growth plates may respond to mechanical stimuli differently.
growthplates  A and B are control group.  C and D are the compressed group.  You can definitely see the compression of cells.

Update Post On The Breakthrough Chemical Relaxin For Bone Remodeling

Relaxin UpdateI do read the comments people leave on the website. Most of those, I don’t respond back, because the person would not put any effort in asking a real question that was worth even thinking about. Only rarely does someone actually write something which is even long enough and technical enough for me to take notice. If you want to get an answer or a response, put some time and real effort in leaving a message. Asking me for a free E-book or a program doesn’t do it.

(Picture Source)

Something that the regular readers have said was the desire on an update on the breakthrough chemical which I mentioned in the post “The Chemical That Would Make Adults Grow Taller Has Been Found – Game Changing Post!“. The claim is that I don’t seem to ever dig deep enough on certain ideas that I share. Well, I will give you the reader an update. I have my personal life and professional life to deal with. This website and project has always been a work of love.

For some background, in that post before I had theorized that this chemical known as Relaxin is the most interesting chemical to ever be found by me or Tyler, and it does have height increasing effects for adults with ossified physis cartilage. How is that even possible? It doesn’t regrow a new growth plate,  but can cause the ligaments and muscles in the area to increase in flexibility. Just like how going to a chiropractor might lead to one having the back readjusted and leading to a height increase for a short time, the lengthening of ligaments in the joint areas of the body will also lead to some level of body lengthening. Not only that, there are receptors in the chondrocyte in growth plates and bone tissue. which respond to the relaxin protein.

In that previous post, I had said that a Dennis Stewart from Bas Medical had been willing to spend around $5,000 to file a patent for this idea, of using Relaxin to remodel bone sutures and in that Patent (refer back to that post) it was claimed that a local injection of relaxin to the growth plate-bone area would result in as much as 30 cm of bone length increase (12 inches).

I am quite certain that over 50,000 readers have already seen that post. Some have gone ahead and looked further into this chemical, to find out what they could from it. One commenter said that relaxin is something humans should avoid taking due to the possibilities of “gynecomastia, hyperestrogenism and most likely CANCER”. Others have shown that it would be very hard, if not impossible to get this compound.

For the claim that this compound is possibly carcinogenic, that is a definite possibility. When I was doing research on PTHrP, the chemical was also shown to allow single cells to proliferate at a high rate which would be considered carcinogenic. However, that is the problem with this type of research. Any compound that can extend the natural limit of cell life or cell proliferation is doing the exact same thing as cancer cells. We are in essence trying to push past the natural growth phase of the human organism. That is why it is highly likely that the chemicals which we claim can increase the limit of chondrocyte proliferation would also have cancer-stimulating effects. Any form of cure or vaccine in large doses will turn poisonous and harmful. They are the exact same thing, just different sides of the same coin.

So here is what I was able to find out, although I have not been putting too much effort into it.

Refer to the Patents below (Note: a Samuel Yue was the patent inventor of 2 of the 3 patents)…

  1. By administering relaxin and glucosamine sulfate to treat osteodegenerative dysfunction in a patient with joint and hip pain; administering relaxin and estrogen to treat alzheimer’s (Patent # US 6251863 B1)
  2. METHOD OF TREATING INVOLUNTARY MUSCLE DYSFUNCTION WITH RELAXIN HORMONE (Yue, U.S. Pat. No. 5,612,051)
  3. Spinal stabilization treatment methods for maintaining axial spine height and sagital plane spine balance (Patent # US 20090093852 A1)

From the 1st patent…

“…Relaxin’s effect on connective tissues during late pregnancy has been well-documented. Relaxin improves the integrity of the connective tissues, maintains the elasticity and circulation of the skin, sustains the youthful and radiant appearance of the face, increases hair and nail growth, and stimulates other changes during pregnancy….Fibromyalgia patients who receive relaxin supplements report a significant decrease of muscle tightness, increased range of motion in their joints, and decreased stiffness of the ligaments and tendons surrounding the joints….relaxin supplements will be given to these individuals who suffer congenitally (probably secondary to borderline deficit of relaxin) from tight muscles, ligaments and tendons to restore the flexibility of the joints and eliminate or arrest the osteodegenerative disease of the joints”

“…Therefore, the production of the collagen by the chondrocytes is facilitated by relaxin. Good quality collagen is produced in the presence of relaxin, which binds with proteogylcan to form strong resilient cartilage. Together with the deactivation of the collagenase by the glucosamine sulfate, homeostasis of the cartilage regeneration and degeneration are maintained and the joint is returned to its formal healthy state. Accordingly, relaxin enhances the effect of glucosamine sulfate in retarding and restoring osteodegenerative changes of the joints.”

I once claimed that almost any type of chemical that an help with treating the pain associated with osteoarthritis or cartilage degeneration has a potential height increasing effect to it as well, after doing research on the effects of Harpagoside on arthritis. It is also known as Devil’s Claw.

It seems that this first patent shows that when you combine Relaxin with Glucosamine Sulphate together, the effect on people suffering from both Osteo-degenerative disease and Fibromyalgia is quite large and profound.

For the regular readers, I am sure that they are fully aware that besides Relaxin, Glucosamine Sulphate was probably the other chemical that was the best option for people interested in growing taller. Glucosamine Sulphate and Relaxin have been the two compounds which was discovered with the highest level of success for adult height increase, even though the affect may more often be just decreased pain in the joint.

In a later section, the patent also shows that Relaxin can be used to stop the onset of osteoporosis, revealing that it is also a bone mineral density stimulant. So it has two effects 1) Combines with Glucosamine Sulphate to treat osteoarthritis and 2) Helps treat Osteoporosis.

From the 3rd Patent

This patent itself was an idea on how to restore the height lost from a compression on the vertebrate bones. The section of the patent where it mentions the use of relaxin in this height increasing invention/technique is where it mentions the different types of muscle relaxers which can be used.

“Other important considerations in the procedure are the state of the patient’s spine at the time of the procedure. For example, if the procedure is performed in the morning, as opposed to latter in the day, the patient may end up with a different height, as disc height is greatest in the morning after a night of sleep due to increased fluid intake, and decreases with axial loading throughout the day. As such, in some embodiments at least the disc treatment portions of the procedure may be performed in the morning shortly after awakening to facilitate increased height of disc fill, for example. This aspect is further refined by the addition of pre-procedure muscle relaxation with intravenous or intramuscular injection of approved pharmaceuticals, e.g., robaxin, skelaxin, soma, etc. In other embodiments, use of paralyzing agents with general anesthesia may be used for more rigid or stiff patients. Use of SSEP (Somatosensory evoked potential) monitoring may be employed to protect the patient against over distraction or correction, elongation or shortening of the spine resulting in spinal cord injury or other nerve injury.”

“To this end, traction, bracing, suspension, inversion tables, therapy, muscle relaxants, chiropractic adjustments, etc. may be used to advantageously place the spine in the desired position prior to the procedure, at Block 112. Moreover, medication such as ligament relaxors (e.g., relaxin) may also be used to achieve natural elongation of the spine before the procedures, and after as well, to achieve the desired axial height increase/stability.

Various combinations of traction, stretching, operating room or office machines, tables, and other equipment may be used. In some embodiments it may be beneficial for patients to have manipulation manually of the spine before procedures to increase height of the disc, hydrate the disc, as well as enzymatically or surgically remove parts of a damaged disc or other anatomical components (e.g., bone) in preparation for the procedure.”

It seems that the person who wrote up this patent fully realized that relaxin, as a type of ligament relaxor, can be used to naturally elongate the spine.

Later in the patent, I quote this section below….

“In another example, a 45-year-old man, who is 5 feet 4 and has always desired greater height, asks his doctor if there is any way to “safely” be taller. The patient would enter index determination, pre-procedure stretching, traction medical muscle and/or ligament relaxor treatment, etc. After a desired elongation (e.g., 1-2 inches) through this pre-treatment, an early morning procedure may be performed to stabilize the appropriate anatomic structures, namely disc and facet joints, and interspinous ligaments (but not vertebral bodies) to maintain this increased height gain. If at some later point in his life it is determined that he is at risk for fractures, then the vertebral bodies could be subsequently stabilized.”

This patent almost states in very simple, elementary school level terms that a 45 year old man can use Relaxin in a program to increase his height by 1-2 inches, combined with stretching, traction, and the actual surgical treatment. Sure, there is always the surgical part, but with a slight implant, you would end up maybe 1.5 inches taller after just 3 days of hospital stay. Much, much faster than any type of limb lengthening surgery today.

Another idea on how to decompress the height of the discs I refer to in the following… “If a patient has spinal stenosis, then the vertebral bodies would be turned into magnets and then manipulated into distraction to stretch the disc, neuroforamina and hence indirectly decompress the nerves.”

From the 2nd patent….

“…Relaxin is well known as an agent for remodelling the reproductive tract via collagen remodelling before parturition, thereby facilitating the birth process….Relaxin is known to increase in peripheral plasma 7-10 days after the midcycle surge of luteinizing hormone and continues to rise to over 800 pg/ml by three weeks if conception occurred. During pregnancy, relaxin levels peak at the 10th week and are maintained at about 500 pg/ml for the remainder of the pregnancy…During pregnancy, relaxin remodels the reproductive tract which includes ripening of the cervix, thickening of the endometrium of the uterus, increasing vascularization of the uterus, and affecting collagen synthesis to cause ligaments and connective tissue to elongate and relax.”

“The relaxin hormone will alleviate these conditions since relaxin acts to effect collagen formation and collagen remodellingRelaxin will alleviate the generalized pain and tenderness by elongating muscles and accentuating joint laxity by remodelling connective tissue (e.g ligaments, tendons, bone, etc.) via collagen changes. This expected effect is based on many studies that have observed that pregnant women have elongated pelvic area muscles, and increased joint laxity resulting from the remodelling effect induced by relaxin

Note two very important things that this inventor Samuel K. Yue has stated.

  1. Relaxin causes connective tissue to elongate and relax
  2. Relaxin elongates muscles and joint laxity by remodelling connective tissue like bones through collagen changes.

Do we not remember one of the first few things we ever learned about cartilage and bone tissue?

  1. Cartilage is made from collagen type II, 
  2. Bone is made from hydroxyapatite calcium crystals which give it compressive strength and then collagen (Maybe type I and type III) which gives it tensile strength. 

If the effect of relaxin is mainly on causing collagen changes, then it changed the tensile strength of the bones which have relaxin receptors. One may not have any more growth plate cartilage to elongate, but if the collagen in the bones are temporarily being decomposed by a relaxin-collagenase type effect, then the tensile strength of bones may be dramatically reduced for a short time during pregnancy.

Even today, I got another message to the website from some woman who says that she grew 1 inch from pregnancy.

Grow Taller Pregnant

This Lauren women who seems to be an alumni from Baylor writes the following in the clipped picture above.

“A few months into my pregnancy I noticed that my sister and mother didn’t seem quite as tall. I Told them I think I am growing and they agreed. I am 8 mo pregnant and measuring almost 1″ taller than the 5′ 5″ I started out at. I’m 27yrs old and didn’t really expect to grow anymore, but I’m not complaining.”

Of course, we are talking about bones here, which have a really high strength. If might be that instead of the relaxin causing the tensile strength of bone to temporarily drop, some other connective joint area of the body was loosened. That would make more sense because evolutionarily speaking, it doesn’t make sense to make a pregnant females pelvis and femur weaker while at the same time having the unborn baby hanging down on the stomach. The pregnant women, being bipedal, when standing up would collapse with weak leg bones.

Of course, then we have to add in the fact that during pregnancy, the level of calcium in the pregnant mother drops too.

Maybe the combined effect of both the calcium being transferred from the mother to the baby and then the effect of relaxin changing the level of collagen in the bones means that the bones just might be weak enough (with both a compressive and tensile strength decrease) that lying down in bed for most of the time and eating a lot of ice cream means that the female body can have the bones weak enough for a slight bit of elongation.

I refer the reader to this website of a Trinity Mills Chiropractor Clinic (website here). They write the following…

“Pregnant women commonly are more flexible due to the hormone relaxin that the body produces to make the pelvis more flexible in preparation for childbirth.  Although these are relatively harmless causes, hypermobility can also be an indication of more serious underlying diseases.  Marfan’s syndrome and Ehlers-Danlos syndrome are associated with hypermobility.  Hypermobility can also contribute to the development of osteoarthritis”

For the regular readers, they might remember that I wrote posts about Ehler’s Danlos syndrome before, and that was because certain females who suffer from Ehler’s Danlos syndrome in their later adult years noticed height increase as well. As for Marfan’s Syndrome, that is also associated with tall stature, due to the connective tissue becoming more elongated. It seems that relaxin has the same type of physiological effect as Ehler’s Danlos and Marfans. It causes the connective tissue to stretch out, and in doing so, the overall person’s body ends up taller.

So does this mean that the chemical relaxin has a chance of making adults with closed growth plates end up taller?

Yes, and that is only said with maybe a 65% confidence level. This research I am doing, it is amateur level at best, since I don’t have a team with me, and I have to collect anecdotal evidence from around the internet. There has been over 20 females who have come forth that I have found which claim that their height changed due to pregnancy. All the physiological steps which would allow for such a thing points to relaxin’s handy work. There is a chance to get the same effect, we also need to have a calcium transfer as well to weaken the bones (ie female pregnancy).

This compound has a synergistic effect combined with Glucosamine Sulphate for symptoms of osteoarthritis, and it has been referenced in patents which were created for a height increasing technique, although surgical in nature. The patent filer explicitly states that you can elongate the spine using this chemical. It has connective tissue remodeling abilities, and I would suspect from the Patent by Dennis Stewart that it is on both cartilage and bone types.

Some people do claim otherwise, like the poster who said “if this method would really work – some people would already made business out of it, and selling the product and injecting it in people for increasing hight.

That is always the first thing a person who doesn’t believe that a new technique is theoretically possible would say. However, do they realize just how much money and time it takes to bring a new medical technique or drug into the market these days? It costs around $500 Mil just to bring a drug which can lower our cholesterol into the market. Even if we showed all the technical theory was accurate and viable, it would still take over $1 Bil to bring this technique to the mass market, which would be years in the making. It is a huge gamble for the large companies.

Plus, they don’t realize just how difficult it is to get this compound. It is extraordinarily expense. The pregnant female will obviously get it for free though. In addition, the actual effects of using it will vary greatly. For just 1mg of this compound, it would cost a person maybe $100,000 and that doesn’t guarantee that it is enough to have any type of big effect on the collagen level of the bones.  I do want to thank some commenter who showed that Novartis bought the rights to make a synthetic version of Relaxin Type 2, known as Serelaxin, RLX030. We as non-medical professionals or chemical lab researchers won’t be allowed to legally get this drug. However, I am sure that with enough money, can get some lab in India or China to make it.