Vosoritide is basically a daily CNP injection. It’s targeted for dwarfism but as everyone has FGFR3 receptors it can work normal children but testing would be needed.
<-From the video it seems that it’s progressing very slowly. Which is unfortunate as it has potential to happen normal children and possibly even adults. Unfortunately it doesn’t seem like they’r keen on testing Growth Hormone and CNP at the same time because Growth Hormone may only increase growth velocity but not final height but perhaps together. They address other potential uses kindof at around the 25 minute mark.
Here’s more on CNP.<-“we developed transgenic mice with an elevated plasma concentration of CNP under the control of human serum amyloid P component promoter and exhibited that these mice showed prominent skeletal overgrowth phenotype”
CNP delays mineralization.->”The femur, skull, and spine (L2-4) measurements were longer than that of the wild-type littermates” It could potentially affect adults via spinal height even if limbs do not increase.
“CNP activates bone turnover and remodeling in vivo”
More on CNP.<-also there’s a snippet from free patents online for CNP being used to increase height in people free of FGFR3 abnormalities meaning normal children.
Who knows if CNP could potentially increase height in adults until it is tested….
Apparently Biomarin did test this on adults but did the adults get taller? Although the study was only for a short period of time approx two weeks which is not a lot of time to evaluate if the adults grew taller.
Note Meclozine has been associated with height growth too.
Note based on this image, barring other effects the benefit of CNP is limited based on how much growth inhibiting effects FGFR3 induces. Though according to Dose dependent effect of C-type natriuretic peptide signaling in glycosaminoglycan synthesis during TGF-β1 induced chondrogenic differentiation of mesenchymal stem cells., CNP may induce differentiation of MSCs to chondrogenic lineage so it’s effects may not solely be limited based on how much FGFR3 there is to inhibit.
“A multinational study of 35 children (5–14 years of age) receiving daily subcutaneous vosoritide at a dose of 15 µg/kg demonstrated a sustained increase in the annualized growth velocity of approximately 1.5–2.0 cm/year over 42 months of treatment.” Let’s say that’s 1.5 inches over 3 years. That’s pretty significant. How long that can be sustained will be revealed with further testing.
thank you.. I thought we lost you for a while there. keep up the good work
Look… Tyler or Minigolfer, we need to talk a lot more I have tried making post on LSJL forum but you for some reason do not respond there at all now, now I will say one thing right now. Xcrunner on the old grow tall forum mentioned using CNP’s and KSBGF’s as another way to grow taller even for adults right? CNP expands the hypertrophic zone of the growth plate, Alkoclar even mentioned before that structural loss was because of the loss of KSBGF’s ( BDNF and BMP derivatives, a group of diverse growth factors and proteins secreted by the kidney) combined with CNP raises cGMP and cGMP has been shown to increase overall size of growth plate. Studies have shown the meclozine has shown to be just as good as CNP if not better for stimulating all the same effects like inhibiting FGFR3 but from what I recall from a study on FGFR3 deficient mice, they had raised Ihh expression, all of the BMP’s and it even downregulates the NOG gene which encodes for the noggin protein so that is even better for our case as for the KSBGF’s : https://evolutionarymuse.com/products/bmp this has kaempferol and kaempferol has been shown to raise KSBGF’s.
Now what we also need is potent pi3k stimulation since it is specifically osteoblast proliferative, since puerarin spray forum isn’t really available right now we need hexarelin and si wu tang for that now and we also need to hypermethylation our DNA to optimal levels (not excessive) because from my research it is very important for another way to induce pituitary tumors like gigantism or leukemia, but SAM-dependent methylation for people with inactive plates takes 6 months to a year to reactivate them, this so we can reverse our growth plate senesensce to peak pubertal growth spurt conditions. All of these interventions together give the most OP stack ever as these people put it: https://grow-tall-forum.proboards.com/thread/14/research?page=1&scrollTo=185
FGF-2 upregulation is what alkoclar is mainly aiming for and he made a 26 year old grow 11 cm with that kind of intervention my full stack is more powerful than that
These interventions are getting tested by quite a lot of people right now by the way, there is a new kind of grow tall forum now but it is a forum for improving your overall looks or the incel community: https://looksmax.me/threads/the-ultimate-pubertymaxxing-guide-an-introduction-into-androgens-and-growth-factors-and-how-to-apply-them.97140/page-12
A lot of people are trying it, even people like Wincel who used to be part of Hakker’s research team is on that site but made a few outdated methods because Hakker’s method is quite outdated in general this is a combination of xcrunner’s and hakker’s methods but I have provided loads of my own research there too, your ‘senior researcher’ can have long time to scruitinise
the final stack recommendation is hexarelin, si wu tang, meclizine, the BMP formula, SAM-e (2g enteric coated tablet), folic acid,folinic acid, glucosamine chondroitin msm easily most powerful stack
Also yes the BMP formula I mentioned https://evolutionarymuse.com/products/bmp here is a write up on it https://anabolicminds.com/community/threads/evomuse-bmp-writeup-updated.272268/ has osthole and osthole has been shown to raise BMP,IGF-1 and upregulate FGF-2
Also take a look at this: https://looksmax.me/threads/the-ultimate-guide-for-heightmaxxing-corrections-to-wincels-stack-included-closed-plate-oldcel-method-included.14298/
This community has been researching height increase that long after the death of the notorious grow tall forum and now with new research and anecdotes, our goals will be reached
Right now I’m focused on mechanical methods. There’s tons of theories but you can’t know for sure until you test and it’s hard to test chemical methods.
glad to see your still posting and active. So do you think it could theorically increase people with closed growth pplates height via spinal increase or does it only works on people with open growth plates?
thanks and hope you’re doing fine
I will start my stack soon:
-Diosgenin 300mg
-Dioscin 300mg
-Icariinn ~200mg
-MK677 25mg
-Meclizine 25 mg
-polysaccharides Lycium barbarum ??mg
-MSM ??mg
-D3+K2 (MK4 not MK7) ??mg
I’m 27
bro lmao what u doing on this site. add sam-e folic acid and folinic acid to that as well bro otherwise i doubt you’d gain much also you need potent pi3k activation since puerarin isn’t around i would suggest u take si wu tang and hexarelin as well
Diosgenin, Dioscin and Icariinn recommended Can Can Alkoclar. MK-0677 increases and maintains elevated IGF-I levels. Meclizine blocks FGFR3. Polysaccharides Lycium barbarum increases FGF-2 levels.
What’s the likelihood of this injection working on adults in your opinion
IT seems unlikely that it will have no effect as it stimulates the articular carilage too.
Have you explored other options? I remember reading something about an Israeli company in the comments to one of your previous posts
Can you be more specific?
Look man, there has been a lot of research and conversation while you have been gone
Hey Tyler, I hope you continue working on this. Congratulations on your new discovery! I love reading your work, thank you for inspiring future hope 🙂