Possible information on how mechanical stimulation can alter the bone.

Increased density and periosteal expansion of the tibia in young adult men following short-term arduous training.

“Tibial bone density and geometry were measured in 90 British Army male recruits (ages 21±3years, height: 1.78±0.06m, body mass: 73.9±9.8kg) in weeks 1 (Baseline) and 10 of initial military training. Scans were performed at the 4%, 14%, 38% and 66% sites, measured from the distal end plate, using pQCT (XCT2000L, Stratec Pforzheim, Germany). Customised software (BAMPack, L-3 ATI) was used to examine whole bone cross-section and regional sectors. T-tests determined significant differences between time points (P<0.05).
Bone density of trabecular and cortical compartments increased significantly at all measured sites. Bone geometry (cortical area and thickness) and bone strength (i, MMi and BSI) at the diaphyseal sites (38 and 66%) were also significantly higher in week 10. Regional changes in density and geometry were largely observed in the anterior, medial-anterior and anterior-posterior sectors. Calf muscle density and area (66% site) increased significantly at week 10 (P<0.01).
In vivo mechanical loading improves bone strength of the human tibia by increased density and periosteal expansion, which varies by site and region of the bone. These changes may occur in response to the nature and distribution of forces originating from bending, torsional and shear stresses of military training. These improvements are observed early in training when the osteogenic stimulus is sufficient, which may be close to the fracture threshold in some individuals.”

” The purpose of this training is to improve physical fitness and teach recruits basic military skills. In a 10-week period, infantry recruits typically undertake 27 periods of military drill, 45 physical training periods comprising of 8 continuous runs, 9 loaded marches (starting at 2 miles carrying a 10 kg backpack building up to 5 miles carrying a 20 kg backpack), 6 swimming sessions and 22 40-min periods of military specific fitness (obstacle course, circuit training, and steeplechase run).”

“There was no significant change in endosteal perimeter at any measured site.”

“Military activities that are not performed often, but likely exceed the strain threshold, include downhill running and/or zigzag motions, which elicit up to 2000 microstrain at the tibial shaft”

This episode has a guest Joel come on to discuss his lifelong desire to become taller and the psychology on why this desired has stayed with him over the years.

Episode #8: Guest Joel Talks About The Psychology Of His Lifelong Desire To Grow Taller

We will go into the subjects of…

• How this desire started
• The actions he took on deciding whether to go through with limb lengthening surgery.
• How this near “obsession” has stayed with him throughout the years.
• His own research into the subject.

Click Here to Subscribe via iTunes and/or leave a review for the podcast!

• Length of time: 48 mins.
• Beginning of actual interview: 1:15

Listen Here – (to download, right click and ‘save’)

Podcast: Play in new window | Download | Embed

I am happy to inform height increase seekers that I might have found one of the first compounds one can take (orally or through injection) which has the potential to lead to increased growth rate and final height for people with open and closed growth plates.

This is only the first in a long list of posts which I will probably do on this new compound i have discovered which seems to have potential which I have never believed was possible before.

Recently I found through the tracking of traffic software I have installed to this website a backlink from a website that is written in the language of Swedish. I was not able to read the swedish words but having Google Chrome as a browser made everything so much easier. Either chrome allowed me to automatically choose the option to translate the page in swedish to english or I right clicked (which is putting two fingers down using a mac osx) on the page screen and clicked the option to translate.

The website link is http://y4ser.wordpress.com/2013/04/06/benens-langdtillvaxt/ . It would seem that many people around the world write about genetics, evolution and how human sex size differences determine mating privileges or preferences. In one of the April 6 posts, one paragraph I found which was translated talked about a chemical compound called Flurbiprofen…

“Flurbiprofen, a compound once thought to aid in easing arthritis pain, has been tested on growing rats. It produces EXPLOSIVE radial bone growth, some rats bones growing by almost 30-40%! And even in the older rats, BMD has increased by 200% in these trials. It even makes the bones grow longer in growing rats (height increase)!

The Holy Grail to bone growth? That’s for us to test, since we are humans rather than rats.

The best part is Flurbiprofen is legal, and doesn’t shrink your nuts while on a cycle of it! Woohoo!

I would feel much safer for my endocrine system development on this!

Sorry if I am jumping the gun on this, I’m just so excited I found these trials!

Opinions?”

The poster would link two scientific articles showing that the chemical compound has an effect on young and old rats/mice.

One is from PubMed: Flurbiprofen enhances growth and cancellous and cortical bone accumulation in rapidly growing long bones. (Abstract below)

The other link he cited was from Science Direct but I would guess that the article he cited can be also found from PubMed, and that the name of the article is “Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older rats.” (Abstract below)

If you are a serious height increase researcher, I would STRONGLY suggest you read and look over these articles!

Two other articles I found which shows that this compound seems to have even more osteoblast effects.

• Alfacalcidol-stimulated focal bone formation on the cancellous surface and increased bone formation on the periosteal surface of the lumbar vertebrae of adult female rats.

• Alfacalcidol prevents age-related bone loss and causes an atypical pattern of bone formation in aged male rats.

There is one major caution which I have to raise up before we go too crazy on the miraculous powers of flurbiprofen just yet. The thing is that even in adult rats, their epiphyseal growth plates never fully go away, but that the cartilage does not completely turn into bone. So even if we are talking about aged, old rats/mice, we must always keep in mind that the scientific experiments done on them can not be directly translated into results that would be the same in humans if humans were the test subjects. So let’s move to the analysis & Interpretation…

Analysis & Interpretation:

From the first study, it seems that the flurbiprofen may have some miraculous bone growth abilities. Not only can it increase the radial thickness of the long bones, it can even stimulate increased longitudinal growth which definitely what we are curious about. However the first study was done on extremely young rats with clearly open large growth plates that can be manipulated. The fact that even the growth plate increased in thickness and that the periosteal layer increased in the appositional growth rate shows that this compound may require much more analysis to see whether it has any possible potential.

The fact that the flurbiprofen is a a non-steroidal anti-inflammatory drug, NSAID seems reasonable. The cortical bone increased in bone density around 15% while the increase in the cancellous bone was around 90%.

The increase in cortical bone is because of the increase in periosteal layer formation but no increased in the size or diameter of the intermedullary cavity. The increase in trabecular/cancellous bone is from the decrease of osteoclasts which are supposed to help induce resorption of bone into the blood stream while not increasing the osteoblast numbers.

The researchers for the first study concluded about flurbiprofen with…

“…the conclusion that flurbiprofen, induced changes in rapidly growing long bones by reducing osteoclast activity and recruitment, stimulating longitudinal and radial growth, increasing the cortical bone mass by stimulated periosteal bone growth and depressed endosteal resorption, and increasing cancellous bone mass by depressed trabecular bone resorption without affecting bone formation”

However it seems that the 2nd study would pull the exuberance by height increase seekers back down since the results are much more sedated. In what are known as 9 month old retired rats, the experiments were done on. If we are to use the term “retired” more liberally, can we assume that the rats were old enough to be considered to have reached physical maturity so that they had not more growth plate cartilage anymore?

I think not.

However the subcutaneous injections of flurbiprofen shows that for the old rat, the long bones did not get any longer, but got thicker where the radial increase was up by 200%. It seems that in the tibial shaft, the increases are due to the fact that the flurbiprofen can decrease the number of osteoclasts leading to increased calcification. Mineral bone formation rate and mineral appositional rate increased. The researchers noted that the bone formation increases seen in the older mice/rats are just not as dramatic as the ones seen in younger lab rats/mice. They conclude with what was said in the 1st study…

“The current study leads to the conclusion that flurbiprofen-stimulated periosteal bone growth was due to direct stimulation of osteoblast recruitment and activity independent of longitudinal bone growth. Further, it confirms early findings in young rats that flurbiprofen induced depressed bone resorption without lowering bone formation…”

Implications For Height Increase: 

I realize now in finishing up the post that my judgement was in haste and I jumped the gun on judgement before I did the full analysis of the studies the guys had listed. It is rather clear that flurbiprofen has tremendous potential to increase bone formation in young children in reducing the effects of osteoclasts. However in older adults there would be little height gain. If the periosteal increases are big enough, maybe we might be able to get more cambium cells in the inner layer of the periosteum but that idea was proven to be unlikely in recent posts.

It seems that the other name for flurbiprofen is alfacalcidol and that on aged and adult rats, as stated in the other two studies linked above is that it does have a stimulatory effect on the periosteal growth of long bones. In aged rats, there are even buds of mineralization found in teh cancellous bone and the cortical bone surfaces but nothing that would indicate any type of longitudinal growth of the bones.

It seems that another possible height increase, bone growth enhancing compound goes down again since it does not have any type of chondrogenic properties.

growthplatebloodsupply

The blood supply of the growth plate and the epiphysis: a comparative scanning electron microscopy and histological experimental study in growing sheep.

” The vascular supply of growth plate and epiphysis of the proximal tibia was reinvestigated using a modern technique, the Mercox-perfusion method, in six sheep aged 6-24 weeks. A comparison was made among pure perfusion specimens, the corrosion casts, and histological sections. The metaphyseal, epiphyseal, and perichondral blood supply systems were confirmed. However, there was evidence of regular transphyseal anastomoses{reconnection of two systems} between the metaphyseal and epiphyseal system. Based on the histological arrangement of the blood vessels, the arterial blood flow would appear to be from the metaphysis to the epiphysis. The existence of transphyseal arterial vessels originating metaphyseally and seen both in cast preparations and histological sections was added to the present description of the blood supply of the growth plate. Age-related differences in the vascularization of the growth plate were not found. ”

I couldn’t copy and paste from the full study at top.

Some vessels do cross the growth plate.

Longitudinal bone growth may cease if blood supply is cut off.

Here’s an image of a growth plate artery:

Cartilage canals run parallel to growth plate columns.

These transphyseal vessels may only be present up to 24 weeks of age.

Note: I am not a big joke or prank guy so I don’t plan to ever joke or prank you guys with a silly April Fools joke like claiming that I grew 1-2 inches in the first month. That just doesn’t happen!

I had said in a post around the beginning of the last month in March entitled “It Is Official, I’m Going To Try To Grow Taller Myself, March 3rd” that I would try to take up exercising again to both try to gain any “hidden height” back which I might have lost in living such a sedentary life since I have been out of the country for the last 9 months.

I had made a vow with my gf that we would try to put ourselves through some type of exercise program to lose weight. We both noticed that we have been putting on the pounds for the last few months with our busy lives and hectic schedules. Or it could be that we are just too lazy to get fit.

So she is now walking much more to work these days (she takes the bus) and I have decided to try  getting back to swimming and stretching like I did years ago when I was trying to gain height. I guess I plan to try to loss weight, get healthy, and possibly also grow taller from my constant exercising and stretching.

She doesn’t realize that In addition to trying to lose weight and get fit, I am also slightly altering my exercise routine to focus more on stretching and decompressing my vertebrate for height increase reasons. She is around 5′ 2″ and has also expressed that she would love to be taller. At this point I haven’t told her that I write or operate this website yet. I am not sure how she would respond when she realizes that I run one of the largest websites on the internet which focus on this subject. Maybe she’ll think I am crazy.

So what is the update after almost 1 month?

Absolutely very little. I have been reducing my food intake, eating one or two small portions of food each day and have been going swimming every other day. I found my old tape measure and looked at whether I had shrunk or grown. It seems that at last measurement my height is about the same as the last time I intentionally really made an effort in measuring myself, which was over 2 years ago. So at least I haven’t shrunk, which is something I do worry about. Whew!

My schedule in flying so much this recent month and running errands and driving to so many places forced me to not have enough time to really do the exercises I was hoping for. By the end of next month however I should have a lot more time and consistency in my exercises and stretching though.

Of course these days I have hair now and I would prefer to measure with my hair on instead of being shaved like before. The hair thing will lead to quite a bit of measurement error. I would like to keep my hair but still get a very accurate reading. Do you guys think I should get a stadiometer for my room?

So I posted a video up of me talking at the Health Sciences Library at the University of Washington, which is the local university library since I am based from the beautiful city of Seattle.

Like I said before, I am going to take the research very seriously now and the only real way that I as a single researcher can make this research more legitimate is get off the scam and internet marketing websites from the internet and sit my ass down in a library and go do research the way my dad did it, by reading old stuffy medical journals and books.

As for my location, the only real good resource I can think of besides talking to a orthopaedic surgeon or endocrinologist is to go to a University with a Medical School which would also have a Medical School Library or Health & Medicine & Biology Library. Luckily, based in Seattle is the University of Washington and the University of Washington Medical School which has been ranked among the best National Hospitals and Medical Schools by US. Newsweek for at least the last few years. It may not be a John’s Hopkins or a Harvard or a Stanford in terms of prestige or name brand  but I believe it is still one of the best Medical Schools in the country

I am just showing you guys the types of books I am looking over these days. The thing I am looking for at this stage is to find any old, previously unknown articles which gives me more knowledge on how the growth plate in the postnatal human behaves.

At this point, I am doing more skimming at the sections and paragraphs because there is just so many books at the library I can go over. It will take me at least a couple of weeks to narrow down the types of subjects and books I want to really go deep on the details on.

The video is short and there is not a lot of content but you do see that I am doing some real research on the stuff and looking at the most relevant subjects.

NOTE: Turn up your volume to hear my voice! I am in a library so I had to lower my voice.

As always, you can check out the Natural Height Growth Youtube Channel or Subscribe by clicking HERE!

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