Monthly Archives: February 2014

New Study indicates LIPUS may help longitudinal growth of bone

In this recent post, Michael indicated that he thought that LIPUS would not help the longitudinal growth of bone.  However, only certain MSCs expressing CMF608 may be able to form new growth plates.  Since LIPUS is a form of mechanical stimulus and CMF608 is sensitive to induced expression by mechanical stimuli, LIPUS may still be able to form new growth plates.

Optimizing a novel method for low intensity ultrasound in chondrogenesis induction

“Among MSCs, adipose stem cells (ASCs) are attractive because of accessibility, their large number, and rapid growth. Common in vitro protocols successfully induce chondrogenic differentiation by expression of multiple cartilage-specific molecules. However, transforming growth factor β (TGFβ) promotes chondrogenesis to terminal stages{which is good for us because that’s what happens in the growth plate to cause longitudinal bone growth}.
In this study, we focused on inducing chondrogenesis in the early stages of differentiation by using low-intensity ultrasound (LIUS). Four groups of ASC pellets (control, ultrasound, TGFβ, and ultrasound/TGF) were cultured under chondrogenic (10 ng/ml of TGFβ3) and ultrasound conditions (200 mW/cm2, 10 min/day){much stronger stimuli than the study that did not find the length difference 30mW vs 200mW}. After 2 weeks, differentiation was evaluated.
Our data demonstrated that ultrasound differentiated pellets showed increased expression of early chondrogenesis marker, Col2A, than those in TGFβ groups, and Col2B and Col10 expression were more prominent in TGFβ groups. Immunostaining of sections showed Col2 fibrils around lacuna in LIUS and TGFβ treated groups.”

“ultrasound transducer directly on cells like chondrocytes or MSCs  [induces] chondrogenesis differentiation.”

“continuous wave at 1 MHz [for ultrasound]”<-the other study was pulsed wave.  Which is surprising as usually pulsed wave results in more beneficial effects on chondrogenesis and/or longitudinal bone growth.

“ASCs were isolated from subcutaneous adipose tissue taken from the knee”<-ASCs have slightly different properties than MSCs.  Also, the ASCs were taken from the knee which would have different properties than stem cells in the epiphyseal bone marrow.

“LIUS produces Col2A more than Col2B. Type IIA collagen is the splice variant of type II collagen that has been found in prechondrocytes and immature chondrocytes.”

“There are major differences between studies of this kind, therefore discrepancy of results could be caused by differences in the cell source, with or without scaffold, and LIUS stimulation mode, particularly transducer–cell distance.”<-explanation as to why the study mentioned by Michael does not indicate that LIPUS cannot aid with longitudinal bone growth.  We wouldn’t be able to affect with or without scaffold(but we could affect the properties of bone via supplements & exercise).  We wouldn’t be able to alter cell source.  We could alter LIPUS stimulation mode and potentially transducer-cell distance.

How Orthopedic Surgeons Perfoming Limb Lengthening Surgery Are Making Over 8 Figures A Year In Salary

How Orthopedic Surgeons Performing Limb Lengthening Surgery Are Making Over 8 Figures A Year In Salary

Limb Lengthening SurgeryAfter this recent podcast posting I did with Andrew on his experience with going through with cosmetic surgery to gain almost 4 inches in extra height, I started to become interested in wondering “just how much money do this doctors make on average, annually?”

I decided to do some “back of the envelope” calculations and if my values are accurate, then orthopedic surgeons who perform the limb lengthening surgery may be the highest paid medical specialty in the world.

About a month ago, I was trying to find information on which medical specialties make the most out of all the medical professions. It turns out that from all the sources I’ve found online, orthopedic surgery is consistently ranked the highest paid specialty. The average values that are usually raised are about $430,000-$450,000/ year in earning for guys who work with the spine specifically. (source 1, source 2, source 3)

There was one resource (here) , which a different value, putting the average earnings much higher, at $710,000/ year.

Orthopedic Surgeon Salary

We find that orthopedic surgeons who perform specifically on the spine makes even more than neurological surgeons and cardiovascular surgeons. I guess the old image of brain surgeons and heart surgeons was not as financially beneficial as we are made to believe. They may be within the top 3, but are not at the top. That goes to spine surgeons.

If we are to assume that the average non-spinal orthopedic surgeon (hip & joint) was making about $600,000, then having a ranking of being an excellent surgeons would increase that salary upwards by 30%, making their earnings to be around $1,000,000/year.

Now these guys are reaching the level of earnings only seen in Investment Banking ($1-$3 Mil/year), Senior Partners at Mckinsey ($2-$4 Mil/year), and Senior Partners at Wachtell, Lipton, Rosen & Katz ($4-$8/year). Only Hedge Fund Managers and Major Movie Stars (and directors) have a higher earning potential per year, and those entertainment guys don’t have the same level of stability has guys in consulting & finance. However, there is a few unique breeds of physicians whose earnings rival even the guys in finance, consulting, and law practice. That is what we are talking about here.

I was recently watching the TV Show House MD, in the 2nd season in the episode “The Mistake“, A surgeon that house tries to bribe (and then blackmail) mentions his salary at the hospital. It turns out that even one of the worst surgeons in the hospital who performs liver transplants makes around $600,000 on average. Obviously the show is not based on reality, but the producers and writers of the show try to be accurate on those types of figures when they do their research, especially for a medicine based tv show. So let’s assume that the value the actor playing the doctor speaks of is reasonable, at $600,000. Of course this was back in 2005, so we would have to take into account the 3-5% increase annually of physician salary to keep up with inflation over the years, even accounting for the factor of the major economic depression of 2008-2009. This is the first indicator that the salaries of surgeons in general are very high. So we can already assume that really good physicians at major hospitals are bringing in already almost 7 figures a year. I remember an anecdote about the highest paid physician in Canada, and his/her earnings per year was around $4-5 Mil/Year.

Something that doctors don’t tell their patients is their salaries, but one well known fact is that doctors who do their own private practices, instead of working in hospitals, clinics, and teach make the most money, but only if their private practice is doing very well with a good marketing department. So let’s increase that factor by another 30% for surgeons.

My own dentist back in Bellevue, WA (one of the richest regions of the USA because of Microsoft, Bill Gates and Jeff Bezos who both live in Medina) was making half a million a year herself from good marketing which she paid for years ago after finding a firm to advertise her services. She was the only dentist with a medical staff of half a dozen dental hygienists, which doesn’t include the front desk people who do all the accounts and billing.

Something that most people who never went to Med School know about is this test called Step 1, which is the first version of the USMLE. It is based on the score you get in this one grade which determines which specialties you can apply and/or get into. The cut off point for passing is around 190 currently but to be considered for the best, highest paid specialities you need to have a score of around 240 usually, with the highest almost always being Plastic Surgery in recent years. What happens is that this three digit number is the best indicator of which residency programs that you would be even matched with. Matching is one of the most interesting processes medical school grads will ever half to go through. You fly around the country, or even other countries to interview with perspective residency programs so that you get to interview the programs/clinics/other physicians and they get to interview you. It really is very much like dating, but only there is no chance that you will end up naked in a hotel room at the end of the interview with the other people (unless it went really, REALLY well).

It might be interesting to ask oneself why is it that plastic surgery matching requires such a high step 1 score. (Read Successfully Matching Into Surgical Specialties: An Analysis of National Resident Matching Program Data). At this point, I guess cosmetic surgery is one of the most lucrative specialties with extremely high payoffs. We know that almost all types of cosmetic surgeries requires that the patient completely pay out of their own pocket. I don’t know any medical insurance plans which cover it. The only medical situation where I would guess is if one decides to use the medical excuse of a deviated septum causing sleep apnea to get a rhinoplasty but even that requires that a person use a medical reason first to justify their desire to get it just for cosmetic reasons.

I’ve been living in the Gangnam area of Seoul for almost a year and a half and I know personally very well just how lucrative plastic surgery can be. A 2 Hour surgery can be a total of $50,000 (and upwards) out of pocket. The BK Hospital based in Nonhyeon-Dong in Gangnam-Gu of Seoul is probably is the most famous and has surgical clients fly in from every corner of the world to go there for their excellent service and high quality of surgeons. There is no insurance, no discounts, just you and your bank account.

If we then combine the specialty of orthopedic surgeons and plastic surgery surgeons together, we create the most lucrative medical specialty there probably has ever existed, cosmetic orthopedic surgeons. Cosmetic Orthopedic Surgeons focus mainly on limb lengthening surgery and helping their clients to become taller. That fact is that even in Seoul, Gangnam there is still only maybe a dozen surgeons who are focusing on this micro-niche of surgical speciality.

Andrew has said that the combined total of his surgery with rehabilitation, room and board, etc. was about 70,000-80,000 Euros. That amounts to around $100,000-$110,000 USD. If Andrew wasn’t from Singapore, which is probably the richest country in the world (maybe Monaco is slightly more), then there is probably no way he would have been able to afford this type of surgery.

That was where I started to do actually do my back of the envelope calculations. The average american worker has an hourly rate, and we take that hourly rate and multiply it by a factor of 2000 to figure out how much their yearly income is. If we just took the $50,000 someone like Dr. Betz makes per surgery, and multiple that by 2000, that comes out to $10,000,000 income per year.

If instead we assumed that Dr. Betz himself did all of the real surgery, then he probably can only perform 1-2 surgeries every working day. If we then multiple the cost of each surgery, at $50,000 with the number of surgeries performed each day, at about 1.5, and then multiple that value by the number of days a person in either the USA or Germany works, around 200 days per year, that comes out to be $50,000*1.5*200 = $15 mil / year.

If we consider the fact that the most well known limb lengthening doctors like Paley, Betz, and Ilizarov have their own clinics and medical centers named after them, then it is not that unreasonable to assume that the best cosmetic orthopedic surgeons are bringing in 8 figures a year consistently. Of course that type of income would only come if one chose the right specialty in the beginning and they went into private practice for themselves, and they would need to chose cosmetic surgery since that would mean that there would be less hassle with the medical insurance people. Forget Insurance, Forget HMOs, Forget PPOs. The people who go to these medical also have to sign NDAs and medical legal forms which completely take away the possibility that the patient can fill lawsuits against the doctor if something goes wrong.

Cosmetic Surgery is notorious for the fact that unlike most other medical practices, there is very little blame on the surgeon, so any problems and complications would not affect them. The medical staff require that the patient understands all of the types of complications that they are likely to experience and makes the patient sign off the chance that the limb lengthening clinics would be legally responsible for surgeon/human error in the operating room.

For course I would guess that the medical doctors don’t pocket the full 8 figures. Half of that probably goes to paying their medical staff, the rent on the land for the clinic, the medical equipment, the annual licensing. At the end, His 8 Figure Salary gets reduced to about $3-5 Mil/year. Nice enough to get two summer homes. Dr. Betz may not be a Michael Bloomberg or Rupert Murdoch who can own their own private jets but he would be earning as much as most CEOs of major Fortune 500 Companies, minus the ridiculous stock options and yearly end bonuses. For limb lengthening surgery, the niche is still sort of like the Old Wild West.

So is there any other type of medical speciality that would be comparable to what these guys do?

I thought about the possibilty of transplants, specifically liver, pancreas, heart, bone marrow transplants. On the website National Foundation for Transplants, we find out that the cost of getting these are in the millions.

Liver Transplant Cost

I am reminded on what happened with Steve Jobs during the 2007-2009 time period after he found out that he had pancreatic cancer. He eventually got the Liver transplant. His name probably got bumped up the list because of his superstar status, his name, and his financial resources. For him, a $2 Million Liver Transplant doesn’t mean too much since Job’s Net Worth was around $5 Billion at the time, when the Iphone and Smart Phone market was still growing at a geometric rate.

So would a cardiac surgeon who regularly performs heart transplants make as much as a limb lengthening orthopedic surgeon? I would say no.

I remember volunteering for a professor who was doing research on plastic surgery after my Junior year in my undergraduate degree. I worked with three other research interns, who were both in the Pre-Med route. One of them had already gotten accepted to Duke Medical School and the UVA School of Medicine. The other was already in Medical School. The one already in medical school expressed to me about how he was one of 6 kids to a Gyno/Obstretrician who had his own private practice. His father who had been a OB/GYN for 30 years had over the last couple of decades been squeezed by the medical insurance companies making his practice and his life a living hell.

Now imagine that situation and multiple it by 3X to understand the malpractice insurance hazards of those physicians who perform heart transplants and liver transplants. With a limb lengthening surgery, it takes you about 4-5 hours to perform one. With a Heart transplant, because you are going to have to literally crack open the sternum, and rip open the chest, it would take usually 10-12 hours of surgical time. Add in the fact that you probably have 3 surgeons performing the surgery, 3 anesthesiologists, and a few nurses on call, and the idea of making slightly more than the low 7 figures goes out the door.

As a cardiac or neurological surgeon, you will make 7 figures, but you are restrained by the rules created by the medical insurance companies forcing you to pay for malpractice and liabilities. If you go with cosmetic orthopedic surgery, you can potentially reach in the 8 figures range.

Natural Height Growth Podcast, Episode 12 – Andrew Tells His Story On Getting Limb Lengthening Surgery

Natural Height Growth Podcast, Episode 12 – Andrew Tells His Story On Getting Limb Lengthening Surgery

Logo1It has been so long since I’ve uploaded a podcast episode that I sort of actually forgot the process on how it was done. It took me about 2 days and 5 hours to remember all the steps and there might be a few things I left out so this post will probably be corrected and edited over time.

Episode #12: Andrew Comes On To Tell His Story of Getting Limb Lengthening Surgery and Answers Questions

Andrew is a currently a young man in his early 20s who went through with the Limb Lengthening Surgery to gain almost 4 inches in height. He went from 1.69 Meters tall (about 5′ 6″) to 1.78 meters tall (about 5′ 10″), gaining a full 9 cms in extra height. In the podcast, he explains how he was able to get up to 9 cm in extra height, the complications he went through, and the type of changes from other people he noticed after he got the surgery.

We actually had to redo the first interview because I found out after the first talk with him that his voice had not been recorded, only mine. (Here is a PDF of the notes on the answers, question and outline of the 1st interview I did with Andrew.)  Some questions were omitted and others were added on for this 2nd interview, which ended up much smoother and of better quality.

Internal Limb LengtheningTo can also get in contact with andrew through his website. His official website is at LegLengthening.Blogspot.Com. It is a free, image based blog similar to Tumblr. We clipped a few of the pictures he uploaded to the website and got the X-rays where the internal nails were still inside his inter-medullary cavity. The picture to the right is of him with the legs shown before the surgery. To see the after pictures, go to the website.

The X-Rays shows how much his femurs have been lengthened after 78 days after the surgery from clicking the internal nail.

X-Rays

After seeing how thin the rods are from the picture to the left, we sort of understand why the rods for him snapped in half cleanly. They do seem to be quite thin.

We note the diagram to the right where Andrew gives us a clue on how the surgical procedure is performed, based on his understanding. Something that I did not ask him in the 2nd version of the interview as whether the surgeons used a hammer and chisel to make the first incision or used a thin saw. It seems that for Betz, he used an electric saw to cut through the bones.

We see that the initial holes to insert the titanium rods are made to the back in the buttocks area.

Guide To Femur


Here is the video we found on him from his Youtube Channel TheAndrewshizzles showing how much his femur bones have healed and the types of movements that he can now perform.


Some major websites, people, and places mentioned include….

andrewshizzlesYou can find his limb lengthening diary on the MMT Forums from the thread “Andrewshizzles – Internal Femurs – Dr Betz – 2011 – Blitzkrieg For 9 CM“. This was one of the most extensive threads and well written dairies on the entire forum. There was a lot of great support from all the admins there.

Dr. Betz for this particular surgery used his own design, which is often called the Betz Bone Method, which is an extension or derivative on the Albizzia Nail. For the internal methods, there are three variations/versions…

  1. Albizzia
  2. Fit Bone
  3. ISDK (Intramedullary Skeletal Kinetic Distractor)

You can also see more information and reviews on Dr. Betz from the Limb Lengthening Forum website. Click Here for the Thread on Him.

Click Here to Subscribe via iTunes and/or leave a review for the podcast!

Length of Time: 41 Minutes

Isoflavones Seem to Delay Puberty Onset In Girls Thus Increasing Adult Height

Isoflavones Seem to Delay Puberty Onset In Girls Thus Increasing Adult Height

IsoflavonesFor the longest time I always suspected that the superficial level of research and understanding that a person with no scientific training would know about some specific area of the hard sciences from just a few hours of study was not enough. I am ashamed to say that I myself suffer greatly from that aspect, since I mostly try to skim through the abstracts of studies, which is not enough to really understand the material. This post is a clear example of that, which seems to refute a previous claim I had made from making the wrong assumption of the effects of a chemical compound, based on not understand the biochemistry well enough.

Many months ago I wrote the post “Phytoestrogens Found In Soy Based Foods May Explain Why Vegetarians and Asian Ethnicities Have Been Historically Shorter (Very Important!)” which proposed an idea that since people of East Asia eat so much soy based products like tofu, the phytoestrogen in their food was probably what was causing them to end up shorter than other ethnicities on average. The idea was that the phytoestrogen found in tofu is very similar to estrogen, which has been responsible for the onset of growth plate fusion. Of course, the problem there was that there were studies which seemed to contradict themselves on the final result.

My argument was something which was raise before on other height increase forums, when the idea of taking Alfalfa to increase height was contested. (Take a look at the thread “worried about isoflavone content in alfalfa and soybeans“)

Isoflavones prefer to bind to ER-Beta. Estrogen goes for ER-Alpha. (The ER stands for Estrogen Receptor). At the time, I was confused as to which type of estrogen receptor (alpha or beta) the phytoestrogen & the isoflavone were more susceptible to attach to.

Matheus, another height increase researcher called me out on my mistake in assuming that ER-Alpha and ER-Beta binding would have similar effects. Clearly they might not after this recent study I have found.

Read his comment/message made to me below

Increasing Adult Height

Matheus might have been right along. The argument made that eating tofu, soy-based products, phytoestrogens, and isoflavones would cause earlier than usual growth plate ossification was not validated.

I refer to the study…

Relation of isoflavones and fiber intake in childhood to the timing of puberty.

From the abstract, we find that for girls who are in the pre-puberty stages, having a higher than average isoflavone diet meant that they actually started puberty much later than their counterparts.

Based on what we understand on the growth progression of adolescents, the girls who started puberty later would on average end up taller when they are adults and have reached full adult bone maturity. This fact is that the main reason why males are on average taller than females later in life is because they started puberty around 1-2 later than females.

There was a 2nd study “Low Phytoestrogen Levels in Feed Increase Fetal Serum Estradiol Resulting in the “Fetal Estrogenization Syndrome” and Obesity in CD-1 Mice” seems to validate this idea. If you take away the phytoestrogen from the diet of pregnant female lab rats, they ended up having earlier than average puberty. In the experiment, the researchers had two groups of pregnant lab rats, which were feed non-soy low-phytoestrogen feed or soy-based high-phytoestrogen feed, and then had the the offspring compared of the two groups.

In addition the baby that they gave birth to started to develop obesity, which is correlated by an increase in the level of estrodial.

At this point, I think we can agree that out of almost every compound we found, estrodial has been one of the worst offenders of growth and would almost always lead to stunted growth.

Increased Height with Iron

Increased Height in HFE Hemochromatosis

” the growth rate affects iron status, and iron demand tends to exceed supply in periods of rapid growth”

“We assessed height in a cohort of 176 patients with HFE hemochromatosis at the University Hospital Zurich”

“All patients had verified iron overload, defined as a serum ferritin level of more than 300 μg per liter or a transferrin saturation of more than 45%. Height in patients with hemochromatosis was compared with that in an age- and sex-matched Swiss reference population”

“Men with hemochromatosis (120 patients) were 4.3 cm taller, on average, than those in the reference population (458,322 persons)”

“The height was 178.2 cm in men with hemochromatosis, versus 173.9 cm in controls. The difference in height between women with hemochromatosis (56 patients) and those in the reference population (10,260 persons) was 3.3 cm. The height was 167.1 cm in women with hemochromatosis versus 163.8 cm in controls.”

“we did not find evidence for an association between the HFE C282Y mutation and so far identified genetic determinants of height.”<-So it was likely the iron that was the factor causing the increased height.

Iron was associated with FGF-23 which may have caused “pseudo-reactivation of the growth plates”.  Iron is inversely correlated with FGF23 and high FGF23 levels were associated with shorter stature.  However, FGF23 was also associated with pseudo-reactivation of growth plates.  Iron reduces LCN2 levels which may also reduce height.

The height difference due to iron is pretty big.  After aging lower iron concentrations may be beneficial to allow for higher FGF23.

Can twisting increase vertebral disc length?

This study seems to indicate that stretching may very well increase vertebral disc height.

Mechanics and Validation of an In-Vivo Device to Apply Torsional Loading to Caudal Vertebrae. 

Torque is the force that rotates around an object.  Torsion is the twisting of an object.

“Axial loading of vertebral bodies has been shown to modulate growth. Longitudinal growth of the vertebral body is impaired by compressive forces while growth is stimulated by distraction. The purposes of this study were two-fold: (1) to develop a torque device to apply torsional loads on caudal vertebrae and (2) investigate numerically and in vivo the feasibility of the application of the torque on the growth plate. A controllable torque device was developed and validated in the laboratory. A finite element study was implemented to examine mechanically the deformation of the growth plate and disk. A rat tail model was used with six 5-week-old male Sprague-Dawley rats. Three rats received a static torsional load, and three rats received no torque and served as sham control rats. A histological study was undertaken to investigate possible morphological changes in the growth plate, disk, and caudal bone. The device successfully applied a controlled torsional load to the caudal vertebrae. The limited study using finite element analysis (FEA) and histology demonstrated that applied torque increased lateral disk height and increased disk width. The study also found that the growth plate height increased, and the width decreased as well as a curved displacement of the growth plate. No significant changes were observed from the in vivo study in the bone. The torsional device does apply controlled torque and is well tolerated by the animal. This study with limited samples appears to result in morphological changes in the growth plate and disk. The use of this device to further investigate changes in the disk and growth plate is feasible.”

vertebraetorquevtorsionFigures of the spine and of the torsion device.

growthplateLeft growth plate is under torsion whereas right is the control group.  You can’t tell if there is any ectopic differentiation of MSCs to chondrocytes as the magnification isn’t high enough.

“Torsional loads are involved [in scoliosis]. While treatment of the spine to generate rotation by application of posterior flexure has been applied, it has been shown that the derotation maneuver using a posterior spine instrument does not consistently correct transverse rotation”

As torque increases, compressive loading becomes more tensile.

“[Torsional loading caused] remodeling at the epiphysial plate with bending of the cartilaginous columns of the growth plate”

5 week old sprague dawley rats were used.

“The morphology of the growth plate was seen to be more curved in the torque-loaded rat, while more flat in the sham rat”

“Overall, the growth plate area in the TG[Torque Group] (0.47 mm2) was greater than the area in the SG[Sham Group] (0.24 mm2)”

“lateral disk space was increased (55–65%), and the middle disk space was reduced by 15%”

“growth plate height is increased and its width is decreased [under torque]. The shear forces derived from the torque may stimulate greater number of endochondral cells in the proliferative zone compared to those in the control group with no shear forces.”

Note that under LSJL the growth plate curves in shape too.  In contrast to the growth plates here, in LSJL the growth plates curve so that the center is the highest part of the growth plate.  Although since only a small portion of the growth plate is shown in LSJL, it’s possible that in LSJL that the extremities curve upwards as well and it’s displaying the same center curvature as shown in these torsion growth plates.

“this curvature may be the result of the shear stress distribution in the growth plate. The sides of the growth plate are pushed toward the center by the shear stress, where the effect is most pronounced, leading to a curved appearance in the growth plate. This curved growth pattern forces the height of the center of the disk to decrease. Furthermore, the disk flows outward because of lower pressure at the outer boundary of the disk leading to increased disk width.”<-LSJL involves shear strain forces too which could also cause the curved shape.

curvedgrowthplateLeft is growth plate under torque whereas right is control.  You can definitely see the enhancement in growth plate quality.

“0.07 mm increase in the disk height at the lateral side of the disk and no change in the disk height at the center of the disk.”

We’re looking mainly at disc height as there’s likely no growth plates in adult vertebrae.

There are 23 intervertebral discs which is 1.61mm total(or .161cm) if every disk gains 0.07mm.  So assuming this a human being could gain 0.06 inches of height.  Of course a human being is bigger than a rat so they would likely gain more mm’s than a rat.  However, only the lateral side increases and not the center of the disc so you may not gain all the height.

Also, it’s not clear if there’s a limit on the height that can be gained this way.

Golfing, pitching, batting, throwing, twisting could all cause torque on the spine to various degrees.

Some stretches would also cause torque on the spine.

Too much torsion can cause hernias.  So it seems as though for now twisting would have only a minor effect on height.