Monthly Archives: February 2014

Reverse Low Bone Density aka Osteopenia Leads To Height Increase In Older Women

I’ve received messages from multiple women and found stories of older women who noticed that their height increased even when they happened to be middle aged. The best example of this happening was the case of where a women in her 40s started to take versions of Vitamin K2 aka Menaquinone and noticed that she gained about 3-4 cm increase in height. Refer to the older post “Increase Height And Grow Taller Using Vitamin K2 aka Menaquinone (Important!)”

Most people have probably not heard of Vitamin K2, but they have heard of Vitamin D, which is often combined with Calcium as a type of commonly sold supplement in any drug store. The Cal+VitD combination is something that is supposed to help increase the bone density and is often advertised on complete vitamin pills for women, like Centrum for Women. We however felt that the supplement is more likely to have negative side effects than increased bone density. I remember watching this video done by a promotor of the Anti-Aging movement who stated that the primary cause for the reduced function in the organ systems is from build up of calcium in various areas, from the arteries (causing strokes and heart attack) to the cartilage (which calcify).

Even if it turns out to be true that the Vitamin D which comes with the Calcium pills might have some positive effect on bone density, there is no correlation between its intake and increased bone longitudinal growth or bone lengthening. Our thoughts right now is that swallowing more calcium may not be the smartest move one can take, especially for people trying in increase their height.

The fact is that the conventional wisdom among professional medical experts seems to be that Vitamin D (The normal type) actually has an adverse effect on growth in children, at least in high dosages taken orally. However, it seems that at least 1 study (High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort.) it was proven wrong. High Vitamin D intake has no correlation, positively or negatively to growth, to growth, not even in children and infants.

So let’s move away from the idea that is believed by the general public, but move towards the other Vitamin, K2. We suspect that Vitamin K2 may be a much better option.

Some background information on Vitamin K2

There are actually a total of 3 different types of Vitamin Ks. You have Vitamin K1, K2, and K3. They are known by the names of phylloquinone , menaquinones , and menadione respectively. Within the subcategory of the K2, it is further divided into 4 types of K2. They are known as MK4 (the most well known), MK7, MK8, and MK9.

MK4 aka Menatetrenone
MK7 aka Menaquinone-7
MK8 aka Menaquinone-8
MK9 aka Menaquinone-9

The compounds are very similar to each other. From Basic Organic Chemistry, all of the following compounds have a type of structure known as the “quinone ring”. The number associated represents how long is the carbon side chain (based from its Wikipedia article)

Based on a few Pubmed studies we’ve found, it seems that MK7 seems to have a positive effect on the bone density in aged females and also decreases the loss of height. We quote the following passage “….significantly decreased the loss in vertebral height of the lower thoracic region at the mid-site of the vertebrae“. The lumbar spine and femoral head showed an increase in bone mineral content and bone mineral density.

There is another compound known as Alendronate which is sold under the commercial title Fosamax, has some effect on the osteoclasts from eating away the bone structure. They act as a type of specific inhibitor of osteoclastmediated bone resorption. This idea of combining Vitamin K2 and with Fosamax is something which we will bring up in future posts.

However, We do find out that Vitamin K1 (NOT Vitamin K2) does NOT seems to help prevent the decrease in bone mineral density for women over a long time range, at least at the 5 mg a day dosage (Study: “Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.“)

Some cultural references to the use of Vitamin K2

For the longest time, the ancient indian medical practice of ayurveda has proposed that taking Vitamin K2 or the types of foods which contain Vitamin K2 is supposed to decalcify the pineal gland. We know the pineal gland as the small gland that is supposed to regulate sleep.

Besides just India, it was found that in Japan, the fermented soybean based food called Natto contains a lot of K2. That seems to help with bone density levels and prevent hip and femoral neck fractures in older Japanese females.

So what do all the studies which show that MK4 and MK7 have bone density enhancing properties prove?

It gives just more evidence in validating this unique story of the middle aged woman who noticed her height increasing over 1 inch after taking MK7 to stop osteopenia.

We suspect that the same bone physiological process has happened to the women who start the reddit thread/story below.

She would increase in height by 1 inch between the age of 21 and 24.

(We are fully ware however that her assessment that she did not menstruate (aka release excess estrogen) would go completely against our hypothesis though. That would suggest that the mechanism on how she grew is due to a completely difference process than what we are proposing. Her inability to have a regular period cycle and menstruate for 12 whole years (while already at the height of 6′ 0″ at 21) suggest that her cartilage did not get the last rush of estrogen release to fully ossify the last bit of epiphyseal cartilage left in her system. teenager symptoms of extreme thinness and ectomorphic body type suggest that she had anorexia causing the last wave of estrogen to be inhibited.)

The main thing is that she went from thin and low bone density aka osteopenia to increased bone density, getting her periods regularly, and normal/balanced hormone release. She never stated what helped her get the balance of her hormones back in order. We suspect that she probably took Vitamin K2.

If we are wrong about the physiological cause for her ability to increase in height in her mid-20s, we would still suggest however that Vitamin K2, which has the ability to reverse low bone density aka osteopenia, would still lead a small percentage of women who have no more growth plates to increase in height. Somehow having a low BMD seems to cause the cortical bone layer to be weak enough to be deformed enough to increase bone volume.

We found almost no studies in Pubmed showing that Vitamin K2 has any type of effect like decalcification of hyaline cartilage, but we hypothesize that it does.

It has already been proven to decalcify the heart vessels aka arteries, decreasing the rate of heart attack and stroke.
It has been speculated to decalcify the pineal gland by Aryuvedic medicine.
So why isn’t it possible that K2 in some form, either MK4 or MK7, might have have the ability to decalcify calcium buildup in the cartilage tissues?

This would suggest that it might renew the ECM structure of hyaline cartilage which gives them elasticity. If our hypothesis can be validated, maybe high intake of Vitamin K2 can result in micro-growth plates and cartilage embedded into the Bone ECM.

From one source, we found the dosage to be around 45 mg/day, which is what is recommended for women suffering from osteoporosis.

How Pregnant Women With Ossified Epiphyseal Cartilage Increase In Height

How Pregnancy Women With Ossified Epiphyseal Cartilage Increase In Height

For almost a year now, we’ve been getting a few comments made by females which suggest that they seemed to have gained anywhere from 1-3.5 Inches in height after pregnancies or multiple pregnancies. The phenomena is something that occurs usually on the first pregnancy, but sometimes the greatest change is seen on the 2nd pregnancy. The range of ages for the women that have posted on the various internet forums have been from 24-34. The one common factor is that they all had gone through with pregnancy, or were going through pregnancy at the time.

The fact is that this phenomena is something that was noticed before by other researchers of height increase in adults. The person who created the website www.HeightEffects.com who called himself Height FX back in 2011 asked on a Mommy Forum about the phenomena trying to get more information. He definitely did his research and knew his stuff, but he never got any answer back from any of the mothers about this most unique of phenomena.

His formulation to help young kids with open growth plates to grow was spot on, with his 4 fold-explanation on how his ‘grow taller pills’ were scientifically validated. The 4 methods he mentions are…

Anti-Fusion Complex
Androgen Optimizing
Somatotropic Signaling
Intracrine Augmenting

In the end, he probably realized that reading another hundred PubMed studies on the mechanism of bone growth, cartilages, and chondrocytes would not be enough. Have a good understanding on the molecular mechanism of human growth and reorganizing the information for easy understanding to validate an internet product (which has the extracts diluted too low to have any effect) is not enough. The science made sense, and it was presented clearly though.

It does not work since there is not going to be some type of PubMed study which would have that type of information. If such a study existed, the researcher would have become a multi-billionaire marketing that method, technique, or idea to Venture Capitalists. He looked for more but never found that.

Refer to our review on the guy and his research in the post “Review Of HeightFX From The Old Height Effects Website”

This entire phenomena is something that we found out about a year ago, but we have not had a lot of time to focus on that path in research. We suspect that this phenomena is much more common than believed, but it is either just not noticed or not reported. Personally, if we were pregnant women, the last thing we would be focusing on is our height. There would be too many things we would be focused on and worrying about. It makes perfectly sense for this type of phenomena to be reported in so few numbers.

Refer to our older posts….

Recently some new information have come in which can explain why a select few women have experienced this most unique of experiences.

If we remember back to our courses in high school about human sexuality and development during puberty, we are reminded of a very unique fact, which is that the hips of the females are supposed to get wider as they are going through puberty. If the hips are getting wider, is it the tissue/fat around the hips that are accumulating, or is the pelvic bone actually becoming wider?

If it is the latter, then how does the physiological process actually work out? How does the pelvic bone wing/iliac crest in the female during puberty get wider?

I was looking for stories & studies about the effects of estrogen on the role of the hip bone, and there were a few women who came forward to state that taking estrogen pills does seem to result in wider hips. That would then explain the connection between wider pelvic bones in women and the increased release of estrogen/female hormone into the system. However, since estrogen is supposed to be increase in puberty for both males an females, then the hips of men should also increase in width shouldn’t it? That is one of the conflicting points of our analysis.

If we look at the way that the entire pelvic girdle area is aligned, we see that the iliac sides are connected to the sacral bone through cartilage types at the sacro-iliac joint, which is in the center region, and they are connected to each other on the anterior (front side) by the symphysis pubis. The Symphysis Pubis is a “….fibrocartilage joint which may contain a fluid filled cavity and is avascular (has no blood vessels) ; it is supported by the superior arcuate ligaments…”

Note this interesting fact: In normal adults it can be moved roughly 2 mm and with 1 degree rotation. This increases for women at the time of childbirth!!

As for the sacroiliac joint, since it is a joint, there are two surfaces of bones covered in cartilage touching each other. You have fibrocartilage-type cartilage on the iliac crest bone surface positioned in the medial direction. You have hyaline cartilage type on the sacral bone surface pointing laterally.

Refer to the studies…

Notice from the picture above how the overall pelvic structure, of the female is wider and thinner in thickness compares to the male’s.

It turns out that one of the most common medical problems experienced by women during pregnancy is lower back pain. Often the blame is given to a condition known as pelvic girdle pain.

That was the beginning of our research. From the Wikipedia article on pelvic girdle pain…

…..Pregnancy begins the physiological changes through a pattern of hormonal secretion and signal transduction thus initiating the remodelling of soft tissues, cartilage and ligaments. Over time, the ligaments could be stretched either by injury or excess strain and in turn may cause PGP…..A combination of postural changes, the growing baby, unstable pelvic joints under the influence of pregnancy hormones and changes in the centre of gravity can all add to the varying degrees of pain or discomfort…”

There is also a very common related medical condition known as diastasis symphysis pubis, which is where there is no fracture, but pubis bones are disconnected. From the Wikipedia article, we quote the following excerpt…

“…pregnancy hormonal influences cause relaxation of the connecting ligaments and the bones separate up to 9 mm. To demonstrate instability of the joint the patient is required to stand in the “flamingo” position, (standing with weight on one leg and the other bent). A vertical displacement of more than 1 cm is an indicator of symphysis pubis instability.A displacement of more than 2 cm usually indicates involvement of the sacroiliac joints”

So the ligaments separate. During normal pregnancy, the separation is around 4-5 mm, but with this certain condition, the separation increases to around 9-10 mm. If the separation is up to 20 mm, then then the effect is no longer in the pubis region, but is also affect the two other joints, the sacroiliac joints in the back.

This explains the idea that during pregnancy, the ligaments holding the three joints which normally hold the entire pelvic region in place making it immobilized, becomes lossened.

We are guessing that the looseneed ligaments around the three joints actually makes the joints expand out, making them almost double jointed in nature. The entire pelvic region can be expanded out. This is for easier passage of the baby through the birth canal, during labor contractions and labor pains.

When we consider the fact that once the joints are expanded, the angle of the iliac crest being positioned to the sacral bone is lowered. If the iliac crest is pulled down by an angle, the hip socket which is part of the bone is also lower. Since the hip joint is lowered, the entire lower limbs/legs become positioned farther away from the torso of the body. This translates to an increase in height.

Sometimes we forget that the overall height of the human is more than just the legs and the spine. There is also the cervical vertebrate or neck, the head, the hips/pelvic bones, and the feet. We can modulate and stimulate anywhere as long as it is safe for the person going through with it.

The Other Possibility

When we first reported this phenomena, Tyler proposed that the most likely explanation is from a chemical/hormonal compound. Just one compound, Relaxin. Refer to the post “The Connection Between Relaxin And Possible Height Increase“

At this point, I am almost positive that Relaxin may be the chemical compound that causes the initial loosening of the ligaments, but the actual morphological change in the structure of the bones is what I propose above, which is where the sacroiliac joint loosen by a certain angle, causing the hips to become wider and the iliac crest to drop lower at the same time during pregnancy.

This idea that the hips get wider is validated by this Yahoo Questions we found “Does your hips get wider during pregnancy?”. One of the people who answers understood the importance of relaxin.

There are enough anecdotal stories and evidence of women who stated that after their first pregnancy, no matter how much they exercised their gluts/buttocks and core muscles, they could never decrease their hip size back down to the length of before ever being pregnant. This sort of indicates that the the problem is not muscle tissue or adipose tissue, since you can mold those through exercise. With bones, you can/t The hypothesis is that their hips or overall pelvic bone structure changed.

This type of change would be enough to explain maybe 1 inch of noticeable change in height, but how would we explain away something as large as 2 inches of increase? At this point, we can only propose that it is a combination of multiple physiological processes.

Process #1

You have the increase in feet size from pregnancy, which has been validated by maybe 10-15% of all women who went through pregnancy. A quick discussion among new mothers will bring up the fact that their old shoes don’t fit. Their feet not only got wider, but also longer. How does the bones in feet make it longer? It can’t just be from the ligaments from loosening, although we are sure that the ligaments loosening is part of it. Somehow the bones in the feet must have also gotten larger, most likely from periosteal growth by the irregular bones in the feet, pushing the long bones in the toe region outwards.

Process #2

What we just proposed, which is that the pelvic bone structure was slightly rearranged, with all 3 main joints become looser. The symphysis pubis increases to 5 mm, but in some bone disorders, it becomes stretched to as much as 2 cm. The sacroiliac joints, which have articular cartilage on the sacral bone surface and fibrocartilage on the iliac bone surface, sort of pops out a little, gaining a higher degree of movement, and range. The result is that from resting on her back, the pregnant women has the two wing-like bones on the sides lower themselves from the central vertebrate.

One of the most common problems during pregnancy is the pelvic girdle pain, where the joints become inflammed. This inflammation means that either one or both of the cartilage surface of the sacroiliac joint becomes thickened. Sure, the cartilage thickness is very , VERY small, at around just 1-2 mm. However, we find out that the cartilage thickness in women is slightly more than in men. The thickened cartilage, to maybe 5 mm or even 10 mm from inflammation due to pregnancy causes the lower body bones to be pushed downwards, thus increasing the overall height of the woman.

Process #3

Due to the release of relaxin, certain intervertebral discs and bones in the lower back and sacral vertebral area become slightly looser. The ligament relaxes, the discs swell up slightly, and the pregnant woman lieing down on her side in the fetal position, pops the intervertebral discs which are almost almost immobile to become mobile for the 9 and a half months when she is carrying the baby. When the pregnancy is over, the discs ossify again, but the change has been that the discs have become slightly thicker.

So the question one might ask is, why is this phenomena not seen more often?

We suspect that more often, pregnant women will actually loose height from their lower back region due to the discs being compressed by the extra weight of the baby.

We suspect that if a women can be induced to be in a constant pregnant state with the same level of hormones (O-estrogen, Progesterone, Follicle Stimulating Hormones, etc) going her body, however without the baby in the uterus, and we placed the woman in some type of spinal decompression machine, attached to her hip region and lower back, she can be stretched out to be 2-3 inches taller, and that height increase would be permanent.

We had proposed this idea that some people, women especially, may have never had their growth plates fused properly “A Theory That Epiphyseal Growth Plates Never Fuse For Certain People“

Just two weeks ago, a women messaged us telling us that even at the age of nearly 30 she found out from an X-ray done after a fall that her growth plates were open.

This phenomena is very common among certain women, and it is hard for us to explain.

The obvious explanation from a social perspective is that these women noticed that their height stopped increasing in their teens and assumed that their growth plates were gone and they won’t grow anymore. They never needed to get any type of X-ray to validate this idea since no-one has X-ray vision to confirm it. A growth plate is not something that you can see with the naked eye.

The best explanation from a mechanistic, molecular, or physiological POV is that the women had a weight and BMI which was much lower than average. The weight load on the growth plates never reached a level to fully ossify the rest of it.

We refer to the PubMed study “Fundamental limits on longitudinal bone growth: growth plate senescence and epiphyseal fusion“.

In the study, it was found that as a person’s weight increases, the weight actually forces the chondrocytes in the resting zone to be used up.

The rate of the depletion of the MSCs that differentiate into the chondrogenic lineage from the resting zone is dependent on the weight on top of the tibia bone (or any bone that contributes to the overall height). Gravity is the force forcing the chondrocytes to be used up.

Mathematically, this phenomena can be described as a type of differential equation.

(alpha)*(-dCh/dt) = W & at t(time) = o , Ch = Constant # of Chondrocytes in resting zone (We are also assuming that the initial number of chondrocytes does not get replenished.) W= weight,

However W = beta*rho*(dCh/dt)^3 (or 3/2)

The need to use a power of 3 (or maybe a 3/2) is due to the fact that a dCh/dt leads to a delH or change in height, which is just 1 dimensional. However, the weight is determined by volume, which is 3 dimensioned, based on W=rho*V where rho is the density of the body. and V=L^3 and dCh/dt=gamma*dL

As long as a person does not go over a certain weight in their torso, the cartilage does not become completely ossified. However, once the person gains too much weight on their upper body, the growth plates are used up.

This would explain our hypothesis that certain people, but especially women, have some epiphyseal cartilage left which was never used up. They never got heavy enough.

We suspect that the type of women who would have this happen are girls who went through anorexia or dieted in the extreme. The low weight and their stunted growth (due to not eating right) would cause the senescence of the growth plates to be arrested. Once they get over the anorexia, maybe in their 20s or even late 20s, the cartilage gets reactivated, and the cartilage goes into catch-up growth. Of course, all of this is just our best guess at this point.

Main Takeaway

A small percentage of women, most likely thin girls during their teenage years, will notice a 1-3 inch of height gain from them going through pregnancy.

Hakker’s HUSS, Hybrid, and H4GS Stack Routine Reverse Engineered

It seems that even right now, in the year 2014, 2 full years after the infamous GrowTallForum.com discussion board was shut down due to the member’s petty arguments, people are still somehow interested in Thomas’s/Hakker’s routines, specifically his HUSS Stack Routine, the HYBRID Routine, or something known as the H4GS Stack. There were some other methods like the H5GS method but we have almost no information about those methods. I am going to fully describe in as much detail as possible what was the extend of Thomas’s research and how far he managed to push the endeavor. We were first made aware of this guy who called himself that name and wrote about him in one of our earliest posts “Who Was “Hacker” And What Was His Method Or Technique? Almost Everything You Wanted To Know”. Back then we were were just going about copy and pasting his old posts from the forums and didn’t get any chance to look over the science of what he was doing.

I personally did interview Thomas on the 5^th episode of the Natural Height Growth Podcast (Click Here to Listen) and he did mention how his stacks eventually worked out. At some point in our discussion, he fully admitted to me (and all that listened to the episode) that while his stacks did work for people with growth plates still available, it would not work on people with closed growth plates, in any of the cases. He also mentioned that I would probably get bored with doing the research, but so far this problem still interests me enough to continue to just read and write.

We did find a list of all the possible compounds that Thomas ever recommended to be in any stack so we guess that one of the combinations and formulations was the HUSS Stack Routine. We noted that in the post “H.U.S.S. Method For Height Increase By Hakker For Stacking Found”

This is my final attempt at trying to summarize every last part of his knowledge into one condensed area. So let’s begin

I was recently looking for more information on this term I remember seeing before called “H4GS” when I found old posts written by Hakker. He had supposedly posted on the BodyBuilding.com website under the names Hakker and iHakker. The threads he wrote for are available Here, Here and Here. People even now have posted on the website (here) looking for more information on his “advanced” methods. There was also supposed to be a website or forum called www.ihakker.com , www.biohakker.com, hakker.betaboard.net, hakker.forumei.net, and www.heightcatalyst.com These are now all dead websites. He’s definitely moved on in his life from this endeavor, which he did give 3-4 years of. There have been some other websites which have been very informative like www.kazlina.com (run by a former moderator of the grow tall forum who called herself Kazlina) and www.heighteffects.com (which was pronounced as Height FX and run by someone also made a real effort in trying to figure it out, also looking into the connection between pregnancy and growth) but all of these website are no longer around either. What I had to do was scrape together everything that I could to give a full summation and outline on his research.

Based on what what he communicated with Tyler, he understood the material at a relatively high level of scientific sophistication. It is time that we take the knowledge that they did, outline it in a way that we can all can digest, and build upon their work and research.

One thing that he did fully agree with was the fact that once your growth plates are fused, you can’t get them back. We quote him saying “It’s impossible to get the growth plates back once they are fused,…”

Here is a few shorthand terms that he would use consistently…

GT4I – stands for the hugely popular E-Book/Scam product “Grow Taller 4 Idiots”. You can download it in PDF form from many websites.
LSJL – Lateral Synovial Joint Loading – just do a search on the website to learn more about this.
Ghen – stands for Ghenerate, which has been a type of pill sold on the internet which is supposed to increase the level of GH in the body.
IGH1 – stands for IGH-1, which was a type of pill that was sold on the internet
CPM1 – is Closed Plates Method 1 – This included LSJL
CPM2 – stands for Closed Plates Method 2 – this method was supposed to possibly regenerate back the growth plates.
MOD GRF – Modified Growth hormone Releasing Factor – a 29 amino acid peptide analog of Growth-hormone-releasing hormone
GHRP2 – Growth Hormone Related Peptide Type 2 – stimulates the pituitary gland’s production of human growth hormone (HGH)

(Note: Everything written in italics are quotes which were originally written by Thomas/Hakker)

6 methods, each consisting of a stack of oral supplements/compounds carefully put together to ensure maximum safety and optimal height gain. In order of potency and growth capability:

So first up:

Method 1 – MENS. This is by far the cheapest and most bang for buck method. For beginners.
Method 2 – HUSS – Advanced stack – ~2.5cm per month
Method 3 – HYBRID – ~3.5cm per month / HYBRID-Injectable ~4.5cm per month
Method 4 – H4GS – Experimental stack – 4cm+ per month

The 1^st routine, called M.E.N.S. Routine Stack

Apparently Thomas did NOT create the routine himself, but it was formulated by something named Cliffs.

This consisted of 4 elements

Melatonin – Dosage: 3 mg – the best time to take the melatonin is around 20 minutes before going to sleep. You want to stay out of the man-made lights after taking the melatonin. The intended effect is for the melatonin to ….” get rid of excess estrogen and promotes deep sleep”

Niacin – Dosage: 100 -500 mg – (Niacin goes by many names, including Niacin B3, B-3, Vitamin B3, and Nicotinic Acid). Its chemical formulation is C6H5NO2)

Warning #1: The study that Hakker’s basis his facts on had the original experimenters deliver the niacin intravenously, through needle and syringe at the amount of 500 mg. He recommend that we do it orally. This represents a huge difference, since many vitamins and minerals we take orally will be removed in the stomach and filtered out by the liver and kidneys, before ever reaching the blood stream. Taking any drug intravenously is much more effective.

Warning #2: The niacin dosage was begun at 375 mg/day, and then increased progressively over the course of the study, and maintained at a level of 2,000 mg nightly for 8 weeks. This is more than 4X what Hakker suggested taking orally.

In terms of how to take it, you take the niacin at a fasting state (on an empty stomach), since it is supposed to supplement and increase the GH releasing effects of Ghrelin. Ghrelin is the enzyme that the release by the stomach to tell the brain that the body is hungry and needs to eat and get nutrition. So again, take the niacin about 3 and a half hours after taking a protein shake. Don’t take any more carbs for at least 3 more hours. Proteins are okay to take, even 30 minutes after taking the Niacin, which should cause the flush. Just no carbs for a few huors.

The protocol he suggests is the following…

Eat meal
Wait 3 hours
Take Niacin at 500 mg
Wait for the flush
Start your workout
Take your protein shake after the workout
Wait 2 and a half more hours afterwards
Take the dextrose powder and carbs

This series of steps is supposed to increase one’s muscle mass at a high rate.

Over the issue of the flush: Most people who listened to Hakker’s advice believe that you should only be taking the flush type of Niacin. Even if you have bought the right type, the flush type, after taking it for a while, one might no longer feel the effect of the flush. Hakker suggests that when this happens, look for other pill bottles sold which have the niacin labeled as “Nicotinic Acid”. (We personally don’t understand the scientific reason for this claim). The other option to take if one is noticing that the flush is no longer there after a certain amount of time, is to stop taking the niacin for 3 days, drop the dosage by half to just 250 mg for a couple of days, and then go back up to 500 mg.

For the experimenters, they didn’t want their patients to feel the effects of the ‘flush’ so they gave the patients some aspirin, which seems to mitigate the flushing effects of Niacin.

Sleep – Duration: 8 hours – since the melatonin you would take is to help the pineal gland to modulate better the circadian rhythm, you want to set your sleeping schedule and cycle to be as close to the rise and set of the sun, which sets the level of ambient light. (So pretend you are our gorilla/primate ancestors long ago and use that type of sleep schedule where they rise and fall based on the sun).

Exercise – sprinting – do the high intensity resistance & high intensity sprints every 2 days. No more than 10 minutes should be enough. The suggested duration is to sprint about 5 minutes just 3 days out of each week, which would be enough. The other suggested way is to do the 5 minute sprints every other day of the week, which averages out to be 3.5 days.

The Cycling Issue for Niacin/B3 – Hakker/Thomas recommended that you use the Niacin every other day.

As for the longer time frame, for the Niacin, take it every other day for two weeks, then cycle off for 1 week. Another options he wrote was to cycle on the niacin for 4 weeks, and then go off the cycle for 2 weeks.

He also wrote that even 5 days of cycling off the niacin after 4 weeks of cycling on it would be enough.

(As the readers can see, some of the information and advice he has given has been inconsistent, about the cycling down time frame. We can only guess that his advice changed over the years after he did more research and became more informed and knowledgeable on the cycling effects of long term niacin usage).

Flush type over the Non-Flush Type

Flush/The correct type – The label states “Vitamin B3 and/or Nicotinic Acid”
Non-Flush/ The Incorrect type – The label states “Niacinamide, Inositol Hexanicotinate, & other Niacin Timed release supplements”

How He Explained Why Taking Niacin Would Work

As we have already stated before in the description of Niacin, Hakker’s reasoning was that the Niacin would have a type of additive effect to the pituitary-hypothalamic GH stimulatory effect of the Grehlin compound, which also stimulates the brain for GH release. He suggested to take the niacin on an empty stomach. Empty stomachs already have the intestinal-neural stimulatory pathway build in. The protein/enzyme Ghrelin signals to the brain that the body is hungry, which is supposed to trigger GH release, based on Hakker’s logic.

His logic was that with a slight nudge to the GHRH and Niacin, you would be able to get the same level of GH release stimulated as using the combination of MOD GRF and GHRP2. He talked about combining 4 different types of compounds to stimulate GH for a maximum GH burst/release, but some of the other things he mentions we still haven’t figured out.

Then mention of how GH release goes by 3 hour cycles is something we couldn’t figure out. He might be basing it on the fact that usually, the GH is released the most during sleep. Sleep is controlled by the circadian rhythm, which is categorized into stages, and measured by the frequency waves from a type of EEG machine. One cycle in the sleep cycle, accounting all the stages, is about 3 hours long.

Read the excerpt from BodyBuilding.com which he posted below.

The Cycling for the Melatonin: Use the Melatonin for 5 days, and then cycle off for 2 days.

This would have been the cheapest and simplest method to implement. You are trying to increase the level of HGH in the entire body/system. The high doses of Niacin and inhibiting aromatase, which is known as o-estrogen, is done using melatonin.

The 2^nd Routine, called the H.U.S.S. HUSS Stack Routine Method

This method is the one that so many people have been trying to get from us for so long. We have gotten dozens of messages asking us what this particular message was. We finally figured it out because of notes left by someone else recently this year. They made a post (Available Here) on the intended effects on what HUSS is supposed to do. The notes that they left helps us reconstruct the stack that Thomas had. It was relatively easy to figure out, once we just used simple logic to reverse the causality process of effects and the pills that would cause them. We also used the list of compounds we had found previous from the post “H.U.S.S. Method For Height Increase By Hakker For Stacking Found”

You are trying to increase the level of growth hormone secretion using whatever peptides and hormones are in your body. You are going to signal to the PI3K pathway to induce the MSCs in the marrow of the bones to differentiate into chondrocytes. If this method was successful, it would have validated the theory that the PI3K pathway was essential in the process of endochondral bone growth.

Two other factors mentioned this stack as intended to do were the following…

Increase the level of DNA methylation or at least keep it at a high enough level. This was supposed to keep the cartilage from fully ossifying or maybe even regenerating back the cartilage tissue.
It is supposed to inhibit the level of somatostatin release into the system.

So let’s figure a few parts out for you guys.

The H.U.S.S. stack stands for 4 elements, just like before.

H – This stands for Hexarelin – Dosage: 50 micrograms per day – take in morning – this would activate the PI3K Pathway. It is a type of GHRP-6 Analog. When combined with the compound GHRH-(1-29)-NH2 (Dosage at 1 microgram/kg) then the two compounds work together has a type of synergistic effect.

The problem with this particular compound is that using it would increase the level of prolactin, cortisol, and desensitization of the receptors so you can’t over use this compound. That is why they tell you to use it just once a day.

Source: The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity.

U – Hyperzine A – Dosage: Unknown – We had to compare the notes of people who had the compounds with other notes made by others to figure out this compound. Note the reason why this stack was called H.U.S.S. – The HU represents the HUperzine A compound. However, that is not enough.

The claim made by the folks is that this compound is a somatostatin inhibitor. The person who posted on the forum just this year stated that for the second stack, the HUSS, one of its intended effects is to inhibit the release of somatostatin into the system. Physiologically it makes a little bit of sense. The GH and the Somatostatin are both released by the hypothalamic-anterior pituitary bi-organ system in a checks-and-balances way. The somatostatin would block the effect of GH. In this way, if you can stop the somatostatin, you give the somatropin (aka GH) sort of free rein to do stuff to the tissue of the system.

S – 3 elements, all for supposedly methylation of the DNA 1. SAM-e, 2. MSM & 3. Chondroitin

SAM-e (S-Adenosyl methionine) (Aka Ademetionine) – Dosage: – Apparently this compound would stimulate DNA Methylation and increases the proliferation of the cells towards the epiphyseal line.

Study: S-Adenosylmethionine and methylation & Growth plate senescence is associated with loss of DNA methylation

MSM & Chondroitin – The MSM stands for (methylsulfonylmethane) is a source of sulfur, one of the most abundant minerals in the human body. Sulfur is essential in many body functions. It’s critical to the production of healthy collagen. This one is the only one which we are not completely confident about. The guess is made because of the emphasize made by Hakker over the fact that multiple elements of a stack was claimed to be used for DNA Methylation. – Dosage: 1000 mg per day

The Explanation on why the S & S stands for SAM-e and MSM & Chondroitin – We had to get this information from PhenomHCL, who was a follower of Xcrunner’s research. It seems that Thomas based his HUSS formulation from Xcrunner’s claims. We found a post made which showed that Xcrunner believed that the growth plates never fully go away. They never fully seal, but only remain inactive. Apparently, if you take SAM-e & MSM & Chondroitin, you can “reactive” the inactive growth plates. For evidence on this rather extreme claim, just check out our clipped picture below.

S – Sleep – 8 Hours, focus on syncing sleep with 8 hours, sun light,

Update Feb 24th, 2014 – We had to rethink this part, since it was something we left out. One of the elements which begins with S should be for sleep. For this, follow the same advice as what is written for the MENS stack routine. 8 hours, focus on sleeping along with natural sun light, and sync one’s circadian rhythm to the cycle of the sun.

As for diet, obviously use good judgement, eat healthy, and focus on real nutrients and vitamins.

The 3^rd Routine, (This might either be the HYBRID Method, part of the HUSS method, or some other method that is a derivative of the HUSS stack but separate from it)

This method is similar to something another forum member created or suggested. This is believed to have been created by Xcrunner, who claimed that he was going to be in Medical School back in those years (2006-2010). The idea again is to prevent bone maturation.

You want to stimulate the PI3K Pathway
You want to stimulate the system to increase the release of IGF-1.
The intended effect was that the rate of osteoblast proliferation would be increased.
The other intended effect from the stack is that it is supposed to keep the feedback loop in the body negative. Apparently, the logic was that if the output of the feedback loop was kept at “negative”, the signal to the hypothalamus-pituitary gland organs would be kept “on” continuing to release more GH (than if the loop would have turned the GH stimulated release off).

It would prevent the accumulation of testosterone in the blood.

There was two supplements Xcrunner mentioned with should possibly let a person continue to increase in height no matter what age a person would be at. We did a few posts on his research in the post “From GrowTallForum.com, Xcrunner211 Notes On Height Increase For Teenage Males With Open Plates, Warning NSFW”

You combine whatever supplements is supposed to be taken with high intensity exercise like basketball to induce microfractures. The natural ability for the bones to cover up over microfracture means that the bones are supposed to grow thicker (and possibly longer) over time.

The 4th Routine – H4GS Stack

One claim made by a recent poster was that this stock is supposed to consistof only 3 main compounds – Letrozole, Oxandrolone, & Ghenerate. We suspect that this stack we have reverse engineered also includes the CJC-1295 & Melatonin.

H – Hexarelin – Read message above on HUSS stack
H – Huperzine A – Read message above on the HUSS stack
H – GHRH-NH2 – this compound is one that Hakker just called the GHRH2 or I-29. It has a very high effect of GH release when combined with Hexarelin
H – IGH-1 – Why the people of the forum was so adamant on using SAM-e, Ghenerate and IHG-1 in combination makes no sense to us.
G – GHenerate – Obviously the G stands for Ghenerate
S – SAM-e – The S represents the SAM-e compound.

Some claims made by Hakker in the beginning

It should be possible to increase in height by 2 inches in the spine or torso region through a combination of using LSJL + GT4I + Ghen + IGH1
Another stack idea proposed which is MENS + Ghenerate + IGH1. Include also the GT4I as well since he states that it will help greatly
He claims that he grew 5 cms in 2 months from doing his own methods. This would have increased his original height of 5 3″ to around 5′ 5″. Based on the ages that we were given, he was probably about 15-16 during that time range.
Apparently Hakker never tried to do the MENS stack, but other types. He did the HUSS Method, Hybrid, H4GS, and some future method called the H5GS.
If you do the MENS routine correctly, you should be able to increase in height about 1.5 cms per month on average.
It is possible to gain 4 inches of height through the spine/torso part only.

Some conclusive thoughts

At some point, people started to accuse that this Hakker guy was a 15 year old young kid who was just 5′ 3″ and wanted to play as super-scientists in one of the various threads that I read. Based on what I did learn after interviewing Thomas, his age at least seems to have been validated.

Some other information about the effects of Niacin, at least hypothesized by Thomas. (source) Almost all of the information about niacin was based on just one main study. (source:“Growth hormone, cortisol and glucagon concentration during plasma free fatty acid depression. Different effects of nicotinic acid and an adenosine derivative“)

“one frequently overlooked “side effect” is that niacin is a powerful releaser of growth hormone (Quabbe, et al, 1983) (Fig. 3). Quabbe and colleagues administered 500 mg niacin intravenously to humans, and noted a dramatic rise in growth hormone.”

During the 2nd half of this study, the experimenters put some fatty acids into the body. The fatty acids blocked the GH release. This is why Hakker has always claimed that one should not eat carbs, since the back building block of carbs, sugars, turns into acids. However, based on that logic, we should say to avoid any fatty foods, since the basic building block of adipose tissues or fats, is fatty acids. Some author also stated that glucose and insulin also inhibits the release of GH, so the basic idea is just don’t eat to let the GH do its work.

The Side Effects

Some sources say that there is no harmful side effects even with high levels of Niacin, but we don’t believe that. If you are taking the flush type, the most obvious side effect is that you will feel this rush of heat through the body like a wave of heat running down the body, similar to the heat in a tanning salon.

The most likely side effect has been some type of damage to the liver. There will most likely be elevation of liver enzymes or liver toxicity.

“Niacin aggravates blood sugar problems in insulin dependent diabetics, further worsening their lipid problems, usually causing their triglycerides to skyrocket. Alternatively, I recommend niacinamide (also contained in Optimum D) in doses up to three grams daily for insulin dependent diabetics.”

What is good about getting the Vitamin B3 intravenously is that it does seem to be doing a better job at increasing the HDL (High Density Lipoprotein) aka Good Cholesterol while also lowering the LDL (Low-Density Lipoprotein) aka Bad Cholesterol (at a lower degree). (Read about the difference between the two types Here from the American Heart Association). The researchers believe that while the HDL helps prevent heart attack, the LDL causes plaque build up in the arteries. In addition, the triglyceride levels were also lowered.

I think we should just admit that the Niacin acts similar to Nitric Oxide. It is a type of vasodilator. It relaxes the vascular smooth muscles and allows more blood flow in the capillaries. This is known as the flush.

In the end, we are only reporting the information currently. It will take us much longer to do the necessary research to see whether these proposed ideas have any validity.

Remember again this though. Thomas/Hakker himself stated to me in the 5th Podcast Episode that none of his stack worked for people who had closed growth plates in the end. That is something to take away from all this and think about. We can not promise anything real either, only that we are going to stick with the research and never stop learning.

Sox9 determines whether BMP2 is chondrogenic or osteogenic

Many of the supplements to encourage chondrogenic differentiation also encourage osteogenic differentiation. Since growth plates are made of chondrocytes, it is much more advantageous to encourage chondrogenic over osteogenic differentiation. Some of these factors include BMP2, TGFBeta1, etc.

This study suggests that Sox9 levels may be one factor affecting whether BMP2 encourages osteogenic or chondrogenic differentiation of mesenchymal stem cells:

Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation.

“Bone morphogenetic protein 2 (BMP2) is one of the key chondrogenic growth factors involved in the cartilage regeneration. However, it also exhibits osteogenic abilities and triggers endochondral ossification{but enchondral ossification is good for height growth, however without the growth base chondrocytes for the growth plate the stimuli for endochondral ossification is pointless}. Effective chondrogenesis and inhibition of BMP2-induced osteogenesis and endochondral ossification can be achieved by directing the mesenchymal stem cells (MSCs) towards chondrocyte lineage with chodrogenic factors, such as Sox9. Here we investigated the effects of Sox9 on BMP2-induced chondrogenic and osteogenic differentiation of MSCs. Exogenous overexpression of Sox9 enhanced the BMP2-induced chondrogenic differentiation of MSCs in vitro. Also, it inhibited early and late osteogenic differentiation of MSCs in vitro. Subcutaneous stem cell implantation demonstrated Sox9 potentiated BMP2-induced cartilage formation and inhibited endochondral ossification. Mouse limb cultures indicated that BMP2 and Sox9 acted synergistically to stimulate chondrocytes proliferation, and Sox9 inhibited BMP2-induced chondrocytes hypertrophy and ossification. This study strongly suggests that Sox9 potentiates BMP2-induced MSCs chondrogenic differentiation and cartilage formation, and inhibits BMP2-induced MSCs osteogenic differentiation and endochondral ossification.”

You’re not going to be able to genetically engineer your mesenchymal stem cells to be transgenic for Sox9 but with supplements and mechanical stimuli you could upregulate the MSC expression of Sox9. Icariin increased Sox9 but only in cells that were already chondrocytes. Electroacupencture increased Sox9 expression. LSJL also upregulates Sox9. Lactoferrin upregulated Sox9 in pluripotent stem cells. Vitamin C increased Sox9 in pre-chondrogenic ATDC5 stem cells. Quercetin increases Sox9 levels. Kaempferol increases Sox9 also in ATDC5 cells.

Quercetin had the most prominent effect on increasing Sox9 in normal stem cells.

“BMP2 induced Sox9 expression was transient and relatively at a lower level during the early stages of MSCs differentiation.”

“Sox9 and BMP2 synergistically promoted chondrocytes condensation and proliferation. However, Sox9 inhibited BMP2 induced chondrocytes hypertrophy, and ossification.”<-So we want optimal levels of Sox9 to form neo growth plates as chondrocyte hypertrophy and ossification are vital stages in the growth plates mechanisms of increasing height.

“Sox9 inhibits BMP2-induced early osteogenic differentiation.”<-So stem cells need to have high Sox9 expression to become chondrocytes but then levels of Sox9 need to increase to undergo endochondral ossification.

“we also explored the effect of Sox9 on skeletal development using the fetal limb culture assay. The skinned fetal limbs were isolated from mouse E18.5 perinatal embryos and cultured in the organ culture medium in presence of AdGFP, AdBMP2, and/or AdSox9 for 14 days. The limbs were infected with indicated recombinant adenoviruses effectively at day 5. On histological examination, both BMP2 and Sox9 induced chondrocytes proliferation and condensation. However, only BMP2 induced chondrocyte hypertrophy and ossification. When the limbs were co-infected with AdBMP2 and AdSox9, the proliferating chondrocyte zone was expanded with no obvious expansion of hypertrophic chondrocyte zone”

“combined treatment of BMP2 and Sox9 had the largest length of proliferating chondrocyte zone, while BMP2 alone exhibited the largest length of hypertrophic chondrocyte zone”<-So you’d be taller if you just had BMP2 and not Sox9. This link is supported by genes such as Twist1 which supress Sox9 but which overexpression increases height.

” Sox9 alone was insufficient to induce MSCs chondrogenic differentiation, but required other growth factors, such as Sox5, Sox6, IGF1, FGF or TGF-β”

“transient overexpression of Sox9 using adenovirus vector was insufficient to induce chondrogenic differentiation of MSCs.”<-So you need sustained expression of Sox9 to induce the initial chondrogenesis.

“exogenous overexpression of Sox9 in BMP2-induced osteogenic differentiation of MSCs showed a significant decrease in the levels of Runx2 expression, sequentially with delayed osteogenic differentiation, and endochondral ossification. Apart from overexpression of Sox9, silencing or removing Runx2 might achieve a similar outcome in BMP2-induced MSCs differentiation.”<-Alternatively inducing Runx2 after chondrogenesis has been inducted by Sox9 might be the right way to get the chondrocytes back on track to endochondral ossification.

Given that you start with an initial pool of progenitor cells to form a growth plate(although the idea with LSJL is to create new progenitors), to maximize height growth you want to maximize the growth per progenitor cell via increasing expression of genes like CNP and Twist1. After this pool is exhausted how much growth you get per cell is less important as any growth is better than zero so it’s more important to induce this initial expression of Sox9 to get the right kind of cells in the first place.

Here’s a study about Notch inhibiting Twist1 which inhibits Sox9:

Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1.

“Notch inhibition of chondrogenesis acts via up-regulation of the transcription factor Twist1. Upon Notch activation, murine limb bud mesenchymal progenitor cells in micromass culture displayed an inhibition of chondrogenesis. Twist1 was found to be exclusively expressed in mesenchymal progenitor cells at the onset stage of chondrogenesis during Notch activation. Inhibition of Notch signaling in these cells significantly reduced protein expression of Twist1. Furthermore, the inhibition effect of NICD1 on MPC chondrogenesis was markedly reduced by knocking down of Twist1. Constitutively active Notch signaling significantly enhanced Twist1 promoter activity; whereas mutation studies indicated that a putative NICD/RBPjK binding element in the promoter region is required for the Notch-responsiveness of the Twist1 promoter. Finally, chromatin immunoprecipitation assays further confirmed that the Notch intracellular domain influences Twist1 by directly binding to the Twist1 promoter.”

“Twist1 is developmentally expressed in mesoderm-derived embryonic tissues and postnatally in adult mesoderm-derived mesenchymal stem cells, where it functions as a major regulator of mesenchymal cell differentiation”

“mRNA expression of both Col2a1 and Agc1 in NICD1-expressing cells was down-regulated at time points 3–7 days, in which NICD1 protein expression was highly expressed, suggest an inhibition of cartilage matrix synthesis at that stage.”

This Non-Prescription Supplement Has Been Scientifically Proven To Make You Grow Taller Even With Closed Growth Plates

The other day I read an article in a business related website from a well known financial writer that it is next to impossible to change people’s behavior. The internal inertia within people (described as entropic entities) suggest that on average, humans will always choose the path with the least resistance, that require the least bit of energy or effort. It turns out that the way to change a person to adjust their lifestyle and their behavior is either through giving pain which is a form of operant conditioning after they correct behavior, or you give the person who might only make the smallest of effort a series of easy wins in the beginning. Apparently the early wins create a type of reward or positive feedback loop pathway. It causes the release of dopamine which makes people want to continue to do the new behavior, as opposed to falling back onto their old behavior and habits. So, I’m going to take that advice and help you guys get a small win. This will be one of the first posts you will see when you arrive to our website Natural Height Growth.

So I guess it is time to just tell the people who visit this website the first, and probably the only, real supplement or pill that has been scientifically proven to increase height in people, even if they have no hyaline cartilage left between their secondary and primary ossification centers (aka growth plates). I once wrote in a very early post about the people’s desire to find some type of magic pill that will make them taller without pain, effort, and maybe just a little bit of money spent (Read the post “There Is No Magic Bullet“). Well, today I’ll tell the people that there is just one type of pill. I am not joking or lying to you guys. This pill will make you grow taller even with closed growth plates. We would never make false claims about just things, since that is not the culture and style of this website.

Caveat: Of course, there is just a slight “catch” about this pill, which I will state at the very end. (If you have been trying to get taller before, you already know the “but” part however the ending is reserved for beginners, people who are just starting out and looking for something that can give them some hope and encouragement in the beginning.)

So what is this pill?

– Glucosamine Sulphate –

At what dosage? 1500 mg

Yes, that’s right. This is one of the most common non-prescription supplement pill which you probably have seen at your local Costco which lets you buy it in bulk. It has been proven to be not just good for your joints in removing the pain from such cartilage degenerative diseases as osteoarthritis, but also has been shown with almost conclusive evidence to help people increase their height, even after all of their epiphyseal growth plate cartilage has disappeared from endochondral ossification completion. However, it does not increase height in the way that most people are led to believe.

Buy the Supplement From Amazon Here

(Note: Yes, the link above is an Amazon Affiliate Link. If you are kind enough to buy the pills, or anything from Amazon through that link, the website will get about 6-7% commission from your purchases.)

What are some possible side effects?

First we note that all supplements are drugs. Let’s remember how our old D.A.R.E course back in middle school defined the term “Drug“. A “drug” is any type of substance , besides food and water, you put in your body that will alter the state of your body or mind. All drugs, taken at high enough dosages can become toxic and start to hurt your body. Even food and water can do that. Remember the story of that woman who died from Dihydrogen Monoxide Poisoning a few years ago trying to win a car? So, our recommendation is this. DO NOT Overdo the dosage. It is asinine to believe that swallowing 5 of these pills in one day is somehow better than just 1. The side effects that are most common has been upset stomach and indigestion. Those are however benign adverse reactions. Also, refer to the WebMD article on Glucosamine Sulfate.

Our Thoughts and Explanations

More than a year ago, we had already questioned the efficacy of this one supplement, and the results and feedback we got about the effectiveness of this supplement in the post “Increase Height And Grow Taller Using Chondroitin And Glucosamine (Breakthrough?)” showed that there was already a lot of interest and belief that this supplement does seem to work. The video we had uploaded was a guy who explained that he managed to increase his height by upwards of even 1.25 Inches (3 cm) from the supplement. (Note: We originally had made a conversion mistake and said that 1.25 inches was 4 cms, but recently corrected it. It is closer to 3 cms)

We reposted that video below so you guys won’t have to scramble around trying to figure out where we have been getting our information from.

Even I started to take the Glucosamine Sulphate in the middle of last year. I wrote about it back in the monthly update post “May of 2013 – What I’ve Been Doing“. I had measured myself and I also noticed around 2-3 millimeters of height increase after 2 months of oral supplementation. I would say that the increase was probably not because of measurement error. I made sure to get about a dozen measurements using mirrors and rulers. That was when I shaved my head and was swimming on a regular basis because I was living back in the US, after traveling around Asia the last year and a half.

The Scientific Proof and Studies

If you guys have any doubts about the scientific proof of this claim, Click Here and you’ll get a copy of the PDF of the randomized, double-blinded, placebo controlled study. The title of the paper is “Effects of Glucosamine Sulphate on Spinal Height: A Randomized, Double-Blinded, Placebo Controlled Pilot Study”

One of the authors of this exact study is Dr Peter McCarthy, from the Welsh Institute of Chiropractic at Glamorgan University, who carried out the study. It is the exact study that was referenced by our older post about the effect of using Glucosamine with Chondroitin. The reference we are talking about was written on the Daily UK Website entitled “Can a pill make you taller in four weeks?” maybe 3 years ago.

The results showed that on average, a person would gain around 2-4 mm of extra height from taking the pill on a regular basis for upwards of 4 weeks. This is assuming that they don’t do anything else to help with the height gain.

The Catch: The pill probably won’t give most people the type of extra height that they would hope for. When we get messages from people asking for help, they ask for usually 4-5 inches. If people are hoping to turn from a Messi into a Peter Crouch, they are going to be severely disappointed. The maximum one would ever expect from this type of pill form of grow taller technique is probably 2-3 cms, but I know quite a few people who have paid almost $100,000 to get just 5 cm of extra height from going through with limb lengthening surgery. (Click here to listen to our interview with Andrew, who did 9 cms of extra height in his femurs through surgery)

So if you are interested in possibly getting upwards of even 3 cms of extra height which might be more permanent that most people would believe, then this pill is the best, cheapest, most convenient option at the current time. This is as close to a cheap form of magic pill as we are probably going to ever get, at least for the next few decades.

Remember that for most people, getting 3 cm is probably very abnormal without other factors included. The extra rewards will require more than just popping a pill into one’s mouth every night before sleep. It won’t be that easy. You will be required to do some types of stretching/decompressing of the vertebrate discs exercises to get more height. Refer to our other post “Restore Spinal Disk Height And Increase Height Temporarily Through Land Based Supine Flexion“. This will get one’s lower back/lumbar intervertebral discs to become fully straightened out/decompressed.

Future Research: There have been claims that Chondroitin, Hyaluronic Acid, and Heparan Sulfate would also work, but let’s just start off by taking this supplement for now, and worry about other supplements for a later time.

Again, here is the link to buy the supplement from Amazon

Misc IGF2 studies

Just because of the Growth in the name IGF2 do not assume anything about it.

Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood.

“Insulin-like Growth Factor 2 (IGF2) belongs to the IGF/Insulin pathway, a highly conserved evolutionarily network that regulates growth, aging and lifespan. Igf2 is highly expressed in the embryo and in cancer cells. During mouse development, Igf2 is expressed in all sites where hematopoietic stem cells (HSC) successively expand, then its expression drops at weaning and becomes undetectable when adult HSC have reached their niches in bones and start to self-renew. In the present study, we aim to discover the role of IGF2 during adulthood. We show that Igf2 is specifically expressed in adult HSC and we analyze HSC from adult mice deficient in Igf2 transcripts. We demonstrate that Igf2 deficiency avoids the age-related attrition of the HSC pool and that Igf2 is necessary for tissue homeostasis and regeneration. Our study reveals that the expression level of Igf2 is critical to maintain the balance between stem cell self-renewal and differentiation, presumably by regulating the interaction between HSC and their niche. Our data have major clinical interest for transplantation: understanding the changes in adult stem cells and their environments will improve the efficacy of regenerative medicine and impact health- and life-span.”<-This is interesting as we would except increasing IGF2 levels to be anti-aging but stimulating existing stem cells with IGF2 could potentially help stimulate new growth plate formation. Stem cells are supposed to be used so decrementing that pool to use them for functions is not necessarily a bad thing.

“[IGF2] is highly expressed in all sites where hematopoietic stem cells (HSC) successively migrate and expand during development ”

“In adult mice, Igf2 appears to be re-expressed in specific cell types during regeneration ”

“As a potent mitogen, IGF2 has been shown in vivo to promote regeneration of tissue mass by increasing cells numbers, and in vitro to expand fetal and adult stem cell populations. Insulin-like growth factor 2 expressed in a novel foetal liver cell population is a growth factor for hematopoietic stem cells. An increase in IGF2 can lead to organ overgrowth ”

“deleting the main paternal Igf2 transcription unit in mice, results in Igf2 deficiency and growth retardation ”

IGF2-deficient HSC may have deregulated interaction with their bone marrow stem cell niche.

IGF2P2 is an IGF promoter.

IGF2P2 deficiency decreased the mobilization of stem cells and progenitors which resulted in higher anchoring of IGF2B2 cells to the BM stroma so again less stem cells being used.

The scientists found that lower IGF2 levels resulted in lower differentiation. So maybe you only want high IGF2 levels during short bursts of time to allow HSCs to recover.