This page is dedicated to understanding to a very high level the structure and function of the bones, joints, and spine. All of tis stuff is written by me from my studies on orthopedics

Note: All citations, references, links, sources, and used material will be labeled with a specific number i.e. Source 1 = (1)

Sources used: Source 1, Source 2, Source 3, Source 4, Source 5, Source 6, Source 7, Source 8, Source 9, Source 10, Source 11, Source 12, Source 13, Source 14

Orthopaedics is the study of the bones, joints, and spine of the human body. Let’s first focus on the bones first. In a toddler’s body there is about 270 bones. There is 206 bones in the human physically mature adult body. (1)

Bones are classified by their shapes. There are 5 main types of bones,

• The long bones,
• The short bones,
• The flat bones,
• The irregular bones.
• The sesamoid bones

An example of a long bone is the femur or humerus. An example of a short bone is the bones of the wrist or ankles. For flat bone, skull bones. For irregular bones, that would be like the vertebrate.

Composition

The majority of the bones is a type of bone matrix, which is made of both living and non living tissue.

1. Living tissue in the bones comprise of bone cells, blood vessels, nerves. For the bone cells, there are 3 main types.

• Osteoblasts – bone cells that build up bone

• Osteoclasts – bone cells that tear down bone

• Osteocytes – mature bone cells that don’t form bones anymore

2. Non-living tissue is the bone matrix which is the collagen fibers and crystalline salts.

Crystalline Salts – The crystalline salt are of two elements, Calcium and Phosphates. The Calcium and Phosphates combine to form hydroxyapatite crystals.

Collagen Fibers – The Type I Collagen make up the organic part of of the non living bone matrix.

What gives the bone its strength?

Answer: Two main components, collegan and the calcium salts.

• Collagen Fibers – gives the bone high tensile strength – is almost as strong as reinforced concrete! (about 150 MPa)
• Calcium Salts – gives the bone high compression strength – stronger than even reinforced concrete! (about 200 MPa)

This suggest that at least for long bones, the bone is less resilient to torsion forces applied. It seems fractures in long bones occurs most when a torsion force is applied.

•  The shear stress strength of long bones is low in comparison to its tensile and compressive load strength at around 50 MPa (2)

Structure 

Let’s only look at the structure of the long bone, like a femur.

The bone is elongated in form. There are two expanded ends of the bone, which are the epiphysis, which forms a joint with another bone. At the very ends of the epiphysis is a layer of cartilage cover called the articular cartilage. For the epiphysis, they are not made of compact bone but of another type of bone called the cancellous or trabecular bone type which is spongy in appearance. The cancellous bone has a high surface area and high porosity, which the cavities being rod and plate like in form.

The shaft in the middle of the bone between the two epiphysis ends is called the diaphysis. Besides the area which the articular cartilage is covering, the rest of the long bone is covered in a layer called the periosteum. Inside the layer of the periosteum is another thicker layer of bone called the compact  bone which is in the diaphysis middle region. This is also very strong, and tough, with a low porosity and make up around 80% of the bone weight of the body.

The cortical bone in the diaphysis forms a inner cavity called the inter medullar cavity in the middle of the bone. This cavity continues on into the spongy bone areas of the epiphysis and is filled with a tissue called marrow. There are two types of marrow, yellow and red. The yellow marrow is found in the inter medullary cavity in the diaphysis region while the red marrow is found in the epiphysis spongy bone area. The yellow marrow is used as fat storage while the red marrow is to create blood cells. The red bone marrow participates in the formation of red blood cells (RBCs) through the process of erythropoiesis

Bone Growth 

Bones, specifically long bones, can grow in three main ways, longitudinally, radially, or by density. This means that the long bone is either going to grow longer, thicker, or stronger.

The type we are trying to achieve is to get the long bones like our femur and tibia to increase longitudinally, especially after the stage of puberty and our epiphyseal growth plates have fused and even the epiphyseal line has disappeared.

First, the formation of bone is called Ossification. There is two types of ossification, Endochondral and Intramembranous

1. Endochondral Ossification:  This type of ossification is the main way for most of the bones in the body to form and grow. There appears to be an initial piece of hyaline cartilage that grows over time. There are 5 main steps in this type of ossification (2)…

• Development of cartilage model
• Growth of cartilage model
• Development of the primary ossification center – It seems the actual endochondral ossification actually starts here.
• Development of the secondary ossification center
• Formation of articular cartilage and epiphyseal plate

2. Intramembranous Ossification: This type occurs during the formation of the flat bones of the skull but also in other bones in the skull and clavicle (2). This type of bone is formed from a type of tissue that is not cartilage, one of them called the mesenchyme tissue. There appear to be 4 steps in this type of ossification…

• Development of ossification center
• Calcification
• Formation of trabeculae
• Development of periosteum

Disorders & Pathologies

The most common types of disorders that affect the bone and skeletal system is osteoporosis. Osteoporosis is where the bones in the body lose their strength and density from increased bone porosity. This leads to an increase in the likelihood of fracture. It happens most often with women who have reached past menopause but it can also occur within men or women who are suffering from certain kinds of hormone pathologies

What exactly causes height increase?

Height increase is actually caused by at least 4 main processes, . Most people would tell you that height increase only comes about from the longitudinal growth of the long bones like the femur and tibia but they are not taking into consideration the growth of other bones in the body, specifically the short bones, the flat bones, and the irregular bones. The 32 vertebrate in our back are irregular bones and they do increase in size when we were still growing and that did contribute to our height. Our torso makes up about 1/3rd of our total height.

However, most people will only focus on the endochondral ossification in the long bones. It is important to note that the short bones also go through endochondral ossification just like the long bones.

Let’s look closer at the process of endochondral ossification. This type of ossification is the type of process in the first formation of long bone, the growth in length of the long bone, and the natural healing of bone fractures. Cartilage is used in this process.

The cartilage goes through a type of growth called interstitial growth which chondrocytes which are cartilage cells divide and multiple while are the same type excreting waste which is used to make up the cartilage matrix .

Another type of growth that happens is known as appositional growth in the endochondral ossification process. This is where the long bones get thicker so the width increases since the extracellular matrix on the edge of the chondrocyte stacked columns also increases from the excretion of the chondrocytes. This happens at the same time new chondroblasts are made in the perichondrium.

For the long bone, there are actually two main areas that experience endochondral ossification, not one. There is the middle part called the diaphysis but also the outer parts called the epiphysis. The middle part is the primary center while the outer parts is the secondary center.

For Primary Center In Middle Diaphysis Section (taken from Wikipedia)

The first site of ossification occurs in the primary center of ossification, which is in the middle of diaphysis (shaft). Then:

• Formation of periosteum: The perichondrium becomes the periosteum. The periosteum contains a layer of undifferentiated cells (osteoprogenitor cells) which later become osteoblasts.
• Formation of bone collar: The osteoblasts secrete osteoid against the shaft of the cartilage model (Appositional Growth). This serves as support for the new bone.
• Calcification of matrix: Chondrocytes in the primary center of ossification begin to grow (hypertrophy). They stop secretingcollagen and other proteoglycans and begin secreting alkaline phosphatase, an enzyme essential for mineral deposition. Then calcification of the matrix occurs and apoptosis of the hypertrophic chondrocytes occurs. This creates cavities within the bone. The exact mechanism of chondrocyte hypertrophy and apoptosis is currently unknown.
• Invasion of periosteal bud: The hypertrophic chondrocytes (before apoptosis) secrete Vascular Endothelial Cell Growth Factor that induces the sprouting of blood vessels from the perichondrium. Blood vessels forming the periosteal bud invade the cavity left by the chondrocytes and branch in opposite directions along the length of the shaft. The blood vessels carry hemopoietic cells, osteoprogenitor cells and other cells inside the cavity. The hemopoietic cells will later form the bone marrow.
• Formation of trabeculae: Osteoblasts, differentiated from the osteoprogenitor cells that entered the cavity via the periosteal bud, use the calcified matrix as a scaffold and begin to secrete osteoid, which forms the bone trabecula. Osteoclasts, formed from macrophages, break down spongy bone to form the medullary (bone marrow) cavity.

For Secondary Center In Outer Epiphysis Section (taken from Wikipedia)

About the time of birth, a secondary ossification center appears in each end (epiphysis) of long bones. Periosteal buds carry mesenchyme and blood vessels in and the process is similar to that occurring in a primary ossification center. The cartilage between the primary and secondary ossification centers is called the epiphyseal plate, and it continues to form new cartilage, which is replaced by bone, a process that results in an increase in length of the bone. Growth continues until the individual is about 26 years old or until the cartilage in the plate is replaced by bone. The point of union of the primary and secondary ossification centers is called the epiphyseal line.

Let’s now see how Apositional Bone Growth occurs. It seems that the long bones get thicker by forming more bones right underneath the periosteum. On the inside, the osteoclasts degrade the long bone to create the hollow cavity in the middle. Eventually once physical maturity is reached, the rate at which bones are formed underneath the periosteum and the rate which osteoclasts degrade the inner bone is about the same so the thickness of the bone stays constant.

Now let’s remember that the cartilage in the growth plates are the type called hyaline. Let’s look to see what exactly is Hyaline Cartilage

The Epiphyseal Growth Plate (from Wikipedia)

The epiphyseal growth plate has 5 main layers to it, the resting zone, the proliferate layer ,the hypertrophic layer ,the calcification layer, and the ossification layer.

1. Zone of resting cartilage. This zone contains normal, resting hyaline cartilage.
2. Zone of proliferation / cell columns. In this zone, chondrocytes undergo rapid mitosis, forming distinctive looking stacks.
3. Zone of maturation / hypertrophy. It is during this zone that the chondrocytes undergo hypertrophy (become enlarged). Chondrocytes contain large amounts of glycogen and begin to secrete alkaline phosphatase.
4. Zone of calcification. In this zone, chondrocytes are either dying or dead, leaving cavities that will later become invaded by bone-forming cells. Chondrocytes here die when they can no longer receive nutrients or eliminate wastes via diffusion. This is because the calcified matrix is much less hydrated than hyaline cartilage.
5. Zone of ossification. Osteoprogenitor cells invade the area and differentiate into osteoblasts, which elaborate matrix that becomes calcified on the surface of calcified cartilage. This is followed by resorption of the calcified cartilage/calcified bone complex.

Hyaline Cartilage (taken from Wikipedia)

Is a type of cartilage found on many joint surfaces. It is pearly bluish in colour with firm consistency and considerable collagen. It contains no nerves or blood vessels, and its structure is relatively simple.

Hyaline cartilage is covered externally by a fibrous membrane, called the perichondrium, except at the articular ends of bones and also where it is found directly under the skin, i.e. ears and nose. This membrane contains vessels that provide the cartilage with nutrition.

If a thin slice is examined under the microscope, it will be found to consist of cells of a rounded or bluntly angular form, lying in groups of two or more in a granular or almost homogeneous matrix.

The cells, when arranged in groups of two or more, have generally straight outlines where they are in contact with each other, and in the rest of their circumference are rounded.

They consist of clear translucent protoplasm in which fine interlacing filaments and minute granules are sometimes present; embedded in this are one or two roundnuclei, having the usual intranuclear network.

The cells are contained in cavities in the matrix, called cartilage lacunae; these are actually artificial gaps formed by the shrinking of the cells during the staining and setting of the tissue for observation. The interterritorial space between the isogenous cell groups contains relatively more collagen fibers, causing it to maintain its shape while the actual cells shrink, creating the lacunae.

This constitutes the so-called capsule of the space. Each lacuna is generally occupied by a single cell, but during the division of the cells it may contain two, four, or eight cells. (see isogenous group)

Hyaline cartilage also contains chondrocytes which are cartilage cells that produce the matrix. Hyaline cartilage matrix is mostly made up of type II collagen and Chondroitin sulfate, both of which are also found in elastic cartilage.

Hyaline cartilage exists on the ventral ends of ribs; in the larynx, trachea, and bronchi; and on the articular surface of bones.

The term “articular cartilage” refers to the hyaline cartilage on the articular surfaces of bones.[edit]Articular Cartilage^[1]

Though it is often found in close contact with menisci and articular disks, articular cartilage is not considered a part of either of these structures, which are made entirely of fibrocartilage.

Chondrocytes (taken from Wikipedia)

Chondrocytes are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans. Although chondroblast is still commonly used to describe an immature chondrocyte, use of the term is discouraged, for it is technically inaccurate since the progenitor of chondrocytes (which are mesenchymal stem cells) can also differentiate into osteoblasts. The organization of chondrocytes within cartilage differs depending upon the type of cartilage and where in the tissue they are found.

Diferrentiation
From least- to terminally-differentiated, the chondrocytic lineage is:

1. Colony-forming unit-fibroblast (CFU-F)
2. Mesenchymal stem cell / marrow stromal cell (MSC)
3. Chondrocyte
4. Hypertrophic chondrocyte

When referring to bone or cartilage, mesenchymal stem cell (mesoderm origin) are undifferentiated meaning they can differentiate into different variance of generative cells (MSC) are commonly known as osteochondrogenic (or osteogenic, chondrogenic, osteoprogenitor, etc.) cell. Undifferentiated mesenchymal stem cell lose their process, proliferate and crowd together in a dense aggregate of chondrogenic cells(cartilage) at the center of chondrification. These condrogenic cells will then differentiate to chondroblasts which will then to synthesize the cartilage ECM(extra cellular matrix). Which consists of ground substance(proteoglycans, glycosaminoglycans for low osmotic potential) and fibers. The chondroblasts then trap themselves in a small space that is no longer in contact with the newly created matrix called lacunae which contain extracellular fluid. The chondroblast is now a chondrocyte, which is usually inactive but can still secrete and degrade matrix depending on the conditions. The majority of the cartilage that has been built has been synthesized from the chondroblast which are much more inactive at a late age (adult hood) compared to earlier years (pre-pubesence)

Chondrocytes undergo terminal differentiation when they become hypertrophic during endochondral ossification. This last stage is characterized by major phenotypic changes in the cell.

Collagen (Wiki)

Collagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of vertebrates. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content. Collagen, in the form of elongated fibrils, is mostly found in fibrous tissues such as tendon, ligament and skin, and is also abundant in cornea, cartilage, bone, blood vessels, the gut, and intervertebral disc. The fibroblast is the most common cell which creates collagen.

Collagen occurs in many places throughout the body. Over 90% of the collagen in the body, however, is of type one.

So far, 28 types of collagen have been identified and described. The five most common types are:

• Collagen I: skin, tendon, vascular ligature, organs, bone (main component of the organic part of bone)
• Collagen II: cartilage (main component of cartilage)
• Collagen III: reticulate (main component of reticular fibers), commonly found alongside type I.
• Collagen IV: forms bases of cell basement membrane
• Collagen V: cell surfaces, hair and placenta

Glycogen (from Wikie)

Glycogen is a multibranched polysaccharide that serves as a form of energy storage in animals and fungi. In humans, glycogen is made and stored primarily in the cells of the liver and the muscles, and functions as the secondary long-term energy storage (with the primary energy stores being fats held in adipose tissue).

Glycogen is the analogue of starch, a glucose polymer in plants, and is sometimes referred to as animal starch, having a similar structure to amylopectinbut more extensively branched and compact than starch. Glycogen is found in the form of granules in the cytosol/cytoplasm in many cell types, and plays an important role in the glucose cycle. Glycogen forms an energy reserve that can be quickly mobilized to meet a sudden need for glucose, but one that is less compact than the energy reserves of triglycerides (lipids).

Polysaccharide represents the main storage form of glucose in the body. Found in the liver and muscles, muscle glycogen is converted into glucose by muscle cells, and liver glycogen converts to glucose throughout the body including the Central Nervous System.

In the liver hepatocytes, glycogen can compose up to eight percent of the fresh weight (100–120 g in an adult) soon after a meal. Only the glycogen stored in the liver can be made accessible to other organs. In the muscles, glycogen is found in a low concentration (one to two percent of the muscle mass). The amount of glycogen stored in the body—especially within the muscles, liver, and red blood cells—mostly depends on physical training,basal metabolic rate, and eating habits such as intermittent fasting. Small amounts of glycogen are found in the kidneys, and even smaller amounts in certain glial cells in the brain and white blood cells.

Alkaline Phosphatase

???

Fibrocartilage (wiki)

White fibrocartilage consists of a mixture of white fibrous tissue and cartilaginous tissue in various proportions. It owes its flexibility and toughness to the former of these constituents, and its elasticity to the latter. It is the only type of cartilage that contains type I collagen in addition to the normal type II.

Fibrocartilage is found in the pubic symphysis, the annulus fibrosus of intervertebral discs, meniscus, and the TMJ. During labor, relaxin loosens the pubic symphysis to aid in delivery, but this can lead to later joint problems.

Formation as a repair mechanism

If hyaline cartilage is torn all the way down to the bone, the blood supply from inside the bone is sometimes enough to start some healing inside the lesion. In cases like this, the body will form a scar in the area using a special type of cartilage called fibrocartilage. Fibrocartilage is a tough, dense, fibrous material that helps fill in the torn part of the cartilage. Yet it’s not an ideal replacement for the smooth, glassy articular cartilage that normally covers the surface of the knee joint.[edit]

Periosteum (taken from Wikipedia)

Periosteum is a membrane that lines the outer surface of all bones, except at the joints of long bones. Endosteum lines the inner surface of all bones.

Periosteum consists of dense irregular connective tissue. Periosteum is divided into an outer “fibrous layer” and inner “cambium layer” (or “osteogenic layer”). The fibrous layer contains fibroblasts, while the cambium layer contains progenitor cells that develop into osteoblasts. These osteoblasts are responsible for increasing the width of a long bone and the overall size of the other bone types. After a bone fracture the progenitor cells develop into osteoblasts and chondroblasts, which are essential to the healing process.

As opposed to osseous tissue, periosteum has nociceptive nerve endings, making it very sensitive to manipulation. It also provides nourishment by providing the blood supply. Periosteum is attached to bone by strong collagenous fibers called Sharpey’s fibres, which extend to the outer circumferential and interstitial lamellae. It also provides an attachment for muscles and tendons.

Cytokines (taken from Wikipedia)

Cytokines are small cell-signaling protein molecules that are secreted by numerous cells and are a category of signaling molecules used extensively in intercellular communication. Cytokines can be classified as proteins, peptides, or glycoproteins; the term “cytokine” encompasses a large and diverse family of regulators produced throughout the body by cells of diverse embryological origin.

Part of the difficulty with distinguishing cytokines from hormones is that some of the immunomodulating effects of cytokines are systemic rather than local. For instance, to use hormone terminology, the action of cytokines may be autocrine or paracrine in chemotaxis and endocrine as a pyrogen. Further, as molecules, cytokines are not limited to their immunomodulatory role. For instance, cytokines are also involved in several developmental processes during embryogenesis

Each cytokine has a matching cell-surface receptor. Subsequent cascades of intracellular signalling then alter cell functions. This may include the upregulation and/or downregulation of several genes and their transcription factors, resulting in the production of other cytokines, an increase in the number of surface receptors for other molecules, or the suppression of their own effect by feedback inhibition.

Effects

The effect of a particular cytokine on a given cell depends on the cytokine, its extracellular abundance, the presence and abundance of the complementary receptor on the cell surface, and downstream signals activated by receptor binding; these last two factors can vary by cell type. Cytokines are characterized by considerable “redundancy”, in that many cytokines appear to share similar functions.

Mesenchymal Stem Cells

Mesenchymal stem cells are a type of connective tissue cell that can differentiate into a few different type of cells, specifically bone cells (osteoblasts), cartilage cells (chondrocytes), and fat cells (adipocytes). It is characterized as small cell body,long and  thin, with a large nucleus. It seems that they have a high capacity for self renewal while still being able to keep their ability to differentiate into other types of cells. The actual differentiation can be induced mechanically or chemically. It seems that the ability to multiply and change into other cells seem to decrease as the person grows older. They secrete cytokines.

How Exactly do Bones Heal from Fracture (dislocation, etc) ?

Bone heal first by having a knowledgeable person put the fractured bone area back into the right position or relocation. The position is stabilized and then the natural bone healing process occurs. A fracture ultimately heals through physiological processes.

The healing process is mainly determined by the periosteum (the connective tissuemembrane covering the bone). The periosteum is one source of precursor cells which develop into chondroblasts and osteoblasts that are essential to the healing of bone. The bone marrow (when present),endosteum, small blood vessels, and fibroblasts are other sources of precursor cells. (from Wikipedia)

Phases of fracture healing (from Wikipedia)

There are three major phases of fracture healing, two of which can be further sub-divided to make a total of five phases;

• 1. Reactive Phase
  • i. Fracture and inflammatory phase
  • ii. Granulation tissue formation
• 2. Reparative Phase
  • iii. Cartilage Callus formation
  • iv. Lamellar bone deposition
• 3. Remodeling Phase
  • v. Remodeling to original bone contour

Reactive

After fracture, the first change seen by light and electron microscope is the presence of blood cells within the tissues adjacent to the injury site. Soon after fracture, the blood vessels constrict, stopping any further bleeding. Within a few hours after fracture, the extravascular blood cells form a blood clot, known as a hematoma. All of the cells within the blood clot degenerate and die. Some of the cells outside of the blood clot, but adjacent to the injury site, also degenerate and die. Within this same area, the fibroblasts survive and replicate. They form a loose aggregate of cells, interspersed with small blood vessels, known as granulation tissue.

Reparative

Days after fracture, the cells of the periosteum replicate and transform. The periosteal cells proximal (closest) to the fracture gap develop into chondroblasts which form hyaline cartilage. The periosteal cellsdistal to (further from) the fracture gap develop into osteoblasts which form woven bone. The fibroblasts within the granulation tissue develop into chondroblasts which also form hyaline cartilage. These two new tissues grow in size until they unite with their counterparts from other parts of the fracture. These processes culminate in a new mass of heterogeneous tissue which is known as the fracture callus. Eventually, the fracture gap is bridged by the hyaline cartilage and woven bone, restoring some of its original strength.

The next phase is the replacement of the hyaline cartilage and woven bone with lamellar bone. The replacement process is known as endochondral ossification with respect to the hyaline cartilage and bony substitution with respect to the woven bone. Substitution of the woven bone with lamellar bone precedes the substitution of the hyaline cartilage with lamellar bone. The lamellar bone begins forming soon after the collagen matrix of either tissue becomes mineralized. At this point, the mineralized matrix is penetrated by channels, each containing a microvessel and numerous osteoblasts. The osteoblasts form new lamellar bone upon the recently exposed surface of the mineralized matrix. This new lamellar bone is in the form of trabecular bone. Eventually, all of the woven bone and cartilage of the original fracture callus is replaced by trabecular bone, restoring most of the bone’s original strength.

Complications of Fracture Healing

The main complications include:

1. Delayed Union: Poor blood supply or infection.
2. Non-Union: Bone loss or wound contamination.
3. Fibrous Union: Improper immobilization

Various studies have found that pulsed electromagnetic fields (PEMF) have increased the rate of bone healing.

Low intensity pulsed ultrasound, applied twenty minutes per day, increases the rate of bone healing.

I was gone for 11 days in China very recently and I only came back 2 days ago. During the time I was staying there, I did not write many articles or posts. When I was writing the posts, there was always a feeling that for me personally, I was sort of spinning the wheels like a hamster. I have currently 396 published posts and very little of it is really worth of great value.

When I copy and paste long articles I thought people were reading these things and I realized that few people who come to the website do what I thought. So here is the plan. I am going to show all of you want my plans are for the next 365 days, because I realize that the endeavor of height increase feels like it is moving too slowly.

For me, I realized that after a certain point in doing all of these articles and writings, I was getting almost nowhere. This is where it is going to change. For us to solve this problem, we have to really focus our attention on this subject and tackle it.

Here are the avenues that I think are the most promising.

1. Stem Cells and Implants

2. Growth Plate implants

3. Bone Morphogenetic Proteins

4. Mesenchymal Stem Cells

5. Transdifferentiation

6. Gene therapy

Here are the topics or article I was supposed to write on but I will not write about…

1. The Implications Of The BMP-7 AND OP-1 Research On Intervertebral Disk Height

2. The Connection Between Noggin Glycoprotein And Height

3. The Connection Between The Parathyroid Hormone-Related Protein (PTHrP) And Height

4. A Study Of The Insulin Growth Factor Receptor, IGF1R

5. Increase Height And Grow Taller Using Hypothalamic Growth Hormone Releasing Hormone

6. The AKT Signaling Pathway

7. Supplement Formulas To Increase Height And Grow Taller

8. Theories On Delaying Puberty To Extend The Growth Period

9. Increase Height And Grow Taller Using Nitric Oxide

10. Increase Height And Grow Taller Using Ghrelin

It is time to get real. it is time to become honest. It is time to get serious.

NOTE: One major thing I will be doing is finding a real medical school textbook on endocrinology and also orthopedics and studying those things to really understand what the hell I am talking about. I want to admit right now that I only understand up to 50% of everything that I have been talking about.

I. Here are the topics that my coworker Nicki has suggested we research into…

jagmonan sachdeva – accupresure scam

dit binaural beats article- add theory of how it could possibly work

http://www.giantscientific.com/height_gain_forum/viewtopic.php?t=702

http://www.begellhouse.com/journals/6dbf508d3b17c437,6dab6d585a096602,5690b6556e9a1a61.html

http://www.growtallerforum.com/index.php?/topic/45-mens-routine-revamped/

http://www.cellsignal.com/reference/pathway/MAPK_ERK_Growth.html

http://www.ncbi.nlm.nih.gov/pubmed/15380808

http://www.ncbi.nlm.nih.gov/pubmed/16614378

http://www.ncbi.nlm.nih.gov/pubmed/21865751

http://www.ncbi.nlm.nih.gov/pubmed/18174286

http://www.ncbi.nlm.nih.gov/pubmed/20974641

http://www.heightquest.com/2011/03/i-have-now-grown-to-full-510.html

http://iwantestatura.webs.com/wolffslaw.htm

http://www.halfsigma.com/2008/10/how-to-make-your-children-grow-taller.html

III. Here are the topics or scientific papers I wanted to review and talk about 

http://bloodjournal.hematologylibrary.org/content/103/5/1662.full

http://www.ergo-log.com/herbal-supplement-ht042-makes-bones-longer.html

http://www.ncbi.nlm.nih.gov/pubmed/12594619

http://endo.endojournals.org/content/144/6/2514.abstract

http://www.ncbi.nlm.nih.gov/pubmed/2837556

IV. From Harald of the Biomedical Growth Research Initiative, I was given a list of scientific articles to look through for ideas which I can’t share on here, yet. 

Me: The truth is that I kind of wanted to start over, and make this site get back to the roots.

Major Change 1: I am going to write only 1 or 2 posts a day but the information in those posts will be of only high quality, the type that you would want to write a comment on and have a heated dissuasion on. I will be challenging the readers to test their intellectual and cognitive ability

Major Change 2: There will be one main page that focuses on the endocrinology of the growth process. There will be another page that focuses on orthopedics.

A. There will be almost no more product reviews since none of the E-products or herbal and amino acid supplements sold on the internet will increase the height of people who are already physically mature. They just don’t work. 

B. There will be almost no more body hacks since since I realize that there are already many websites on the internet that talk about that kind of stuff. This site was created to find a solution to height increase, and that should be what this website should focus on. 

C. Since I do believe that increasing one’s intelligence is important, a few mind hacks for learning how increase one’s intelligence will still be posted. 

D. There will be no more long posts, fewer but in better quality material, and nearly everything that I write will be from my interpretation. Sometimes I will quote small passages from scientific articles or papers but they will be in the italics font with quotations marks around them. My writing will be in normal “times new roman” font.

E. All facts or statement I will try to validate through links, sources, references, and citations. If I make a claim on a scientific principle or idea, I will show you where I got the idea from. 

That will be all for now. I promise to make this website really worth the time you use to come here and read my material. The late Steve Jobs stated in his most famous delivered 2005 Stanford Commencement Address (found HERE) …

“If you live each day as if it is your last, someday you will most certainty be right…It made an impression on me. Since then, for the past 33 years, I have looked into the mirror every morning and have asked myself ‘If today was the last day of my life, would I want to do what I am about to do today?’…and whenever the answer has been ‘no’ for too many days in a row, I know I need to change something! …Remembering that I will be dead soon is the most important tool I have ever encountered to help me make the big choices in life, because almost everything, all the external expectations, all pride, all fears of embarrassment or failure, these just fall away in the face of death, leaving only what is truly important….”

and finally

“Remembering you are going to die is the best way I know to avoid the trap of thinking that you have something to lose. You are already naked. There is no reason not to follow your heart…”

Me: I remember just 3 weeks when I was sitting at the cafe where I am sitting right, now, only 3 feet from where I am sitting right now typing away on my Macbook Air laptop, and I found myself miserable. I have proclaimed that I would create a website that would help find a solution on height increase and I was not really doing what my original intentions were. I found myself miserable. I dreaded opening up the laptop and trying to grind out another post on the link between height and some chemical compound. I felt like I was running in circles and making no headway. When I asked myself the Steve Jobs question of whether I would do what I wanted to do if that day was the last day of my life, I said no, at least 10 times in a row. I knew something had to change. I had to change. My environment had to change. So I bought ticket to Shanghai and flew there, for rest and to think. I wanted to refocus my energy and gather my thoughts to see what I was doing.

I realized today after coming back to Seoul that I was not being completely honest, not with you the readers or with myself. I wasn’t really making a true contribution to the world. I was only repeating knowledge and information that thousands, if not millions of people before me have already known and repeat as well. How am I expected to make any real contribution and progress in this endeavor if I don’t raise my own standards and o what I said I would. I needed to  raise my own level of thinking, of problem solving. I have to be better.

When I got on that plane to fly out of Seoul nearly two weeks ago, I found myself feeling the same type of uncomfortable dread in the pit of my stomach which I have always felt a little of before fit takes off. I have been afraid of death, and one of the main reasons was that I haven’t made any real contribution to the world. What have I done or given to the world to make it better? What if I die without ever giving my gifts and talent to this world to leave it a better place than when I arrived? I truly believe that if I can make a big contribution in this endeavors, my heart will be a lot lighter the next time I get on the place. I will be less afraid to die.

I’m sure most of you have already seen part or all of the entire video with Jobs before but I think it is worth your time to watch it at least one more time. I believe it is really worth your time.

From HashmiHealthcare.Com, this is what the product sellers claim on the front page. Also found from PXXL.in…

Height increase supplement

Boosts natural process of Growth and development of the body. Builds and tones Muscular mass by promoting new cell and tissue growth. Improves Metabolism which further leads to lean body. Strengthens Nervous System. Maintains Cholesterol levels and is a good tonic for Heart. Helps in patients of Insomnia. Slower down’s aging process. Reduces extra fat. Increases memory power. Produces Amino acids that work as a food supplement for Pituitary.

HighTole-XL Capsule is a no 1 Capsule for height increase, grow taller with the most potent height increase formula on the market today worldwide with results that are guaranteed.This Capsule supplement is 100% natural and safe with no harmful side effects. HighTole-XL Capsule is a height growth supplement.HighTole-XL Capsule is a powerful safe and effective to grow taller formula to help you.HighTole-XL Capsule is a height growth and grow taller supplement which helps people to gain extra inches in their height growth.The product is very much effective and result oriented.

How Hormones help our body to grow taller: As we all know that growth hormone plays key role in any ones height growth. In normal course an Individual’s pituitary gland releases, about 7/10th of a milligram of growth hormone in 24 hour. Where as half of this amount is released within the first hour of sleep and rest of the hormone is released. Sleep is the major stimulator of growth hormone, physical exercise is next in the line. In fact the intensity of Growth hormones peaks higher during exercise as compared to sleep. Several things influence the magnitude and intensity of growth hormone released during exercise.

The intake of HighTole-XL Capsules help body and mind to undergo sound sleep which is a must for repair of cells and production of new cells and harmones. As mentioned above this herbal supplement promotes nervours system, improves Metabolism, help body to enhance making of tissues and also helps in the process of Bone growth.

As this height growth system is based on supplement + Exercise, We recommend some specific type of workouts along with supplement intake. These specific workouts promotes growth by following above mentioned principles of growth.

Grow taller program and Height growth supplement ” HighTole-XL Capsules “

For the last Six years this grow taller program + height growth supplement “HighTole-XL Capsule ” has been considered the best source of safe growth and supplementing worldwide, and provides you with the fastest growing results. HighTole-XL Capsules – A High quality, 100% risk free increase height herbal formulation to help you grow taller and faster by regenerating your bones and cartilages.

Out of the many grow taller programs and height growth supplement out there, why is Grow taller program and height increase supplement HighTole-XL Capsules the safest and ultimate choice? – Because it thoroughly researched grow taller system and it is based on modern and ancient techniques of Yoga and Ayurveda, this herbal formulation comes from natural sources! The revolutionary most potent formula HighTole-XL Capsules not only can increase height, but will help one’s bones recover and grow faster by boosting natural height growth.

Me: You can buy a 1 month supply of the HighTole XL capsule for $73.50 and apparently you can pay for this product buy using your credit card or using Paypal. How convenient. I am really tired today and I don’t want to get into the long scientific discussion on its effectiveness or feasibility. Just read the conclusion.

Conclusion: It is a scam. It will not work for people who are physically mature.

While I was doing research on Larons Syndrome, I found out about the startling fact that people who have Laron Syndrome which is a lack of the growth hormone receptors to work, seem to have extremely low rates of cancer and diabetes, as well as increase in their lifespan. I don’t want to talk too much about the subject but will let the writers who wrote articles about this phenomena speak.

From the New York Times (source HERE)…

The article I am posting below found from HERE seems to suggest that the GH that bodybuilders have been taking for so long to increase muscle size may not do that either, let alone increase the length of the long bones to grow taller.

I personally found the article to reveal another layer to this mystery of GH. It could be possible that the GH that the experimenters used to test the subjects with was not pure somatropin but a lower quality  synthetic version which is not as effective but I doubt that is the reason. If growth hormones don’t even increase muscle size but bulking up body builders, then the use of growth hormones for adults is very limited.

Research debunks bodybuilding myth: Growth-promoting hormones don’t stimulate strength

New research from scientists at McMaster University reveals exercise-related testosterone and growth hormone do not play an influential role in building muscle after weightlifting, despite conventional wisdom suggesting otherwise. The findings indicate that bodybuilders who look to manipulate those hormones through exercise routines are wasting their time.

In two separate studies, published in the Journal of Applied Physiologyand the European Journal of Applied Physiology, researchers found anabolic hormones — long thought to be essential for building a muscular frame — do not influence muscle protein synthesis, the process that leads to bigger muscles.

“A popular mindset for weightlifters is that increased levels of hormones after exercise play a key role in building muscle,” explains Daniel West, lead author of both studies and a graduate student in the Department of Kinesiology at McMaster. “That is simply not the case.”

In the first study, researchers examined the responses of both male and female participants to intense leg exercise. Despite a 45-fold difference in testosterone increase, men and women were able to make new muscle protein at exactly the same rate.

“Since new muscle proteins eventually add up to muscle growth, this is an important finding,” says West.

“While testosterone is definitely anabolic and promotes muscle growth in men and women at high doses, such as those used during steroid abuse, our findings show that naturally occurring levels of testosterone do not influence the rate of muscle protein synthesis.”

In the second study, researchers analyzed the post-exercise hormonal responses of 56 young men, aged 18 to 30, who trained five days a week for 12 weeks in total.

The men experienced gains in muscle mass that ranged from virtually nothing to more than 12 pounds, yet their levels of testosterone and growth hormone after exercise showed no relationship to muscle growth or strength gain.

Surprisingly, the researchers noted that cortisol — considered to have the opposite effect of anabolic hormones because it reduces protein synthesis and breaks down tissue — was related to the gain in muscle mass.

“The idea that you can or should base entire exercise training programs on trying to manipulate testosterone or growth hormone levels is false,” says Stuart Phillips, a professor in the Department of Kinesiology. “There is simply no evidence to support this concept.”

The research was funded in part by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.

This is another story I thought was important to be told. The individual is Tiffanie Didonato who had suffered from a type of dwarfism called Diastrophic Dysplasia, which made her only 3 feet 6 inches. Through out my research, this person has gone throughout the most height gain I have ever heard of with over limb lengthening surgery. However, I have known and heard that for people who suffer from type soy dwarfism, limb lengthening surgery gives them the greatest of height increase.

It seems from reading on other forums that people who are only below average in height but is not at the level of dwarf often go to limb lengthening surgery for 3-4 inches in height. Most of the stories I have read about people who suffer from dwarfism who get limb lengthening surgery seem to increase height the most with stories I have heard of being 10 inches, or more. They seem to get the most benefit from this procedure. This story was the most dramatic. The problem with this story is that the numbers don’t really add up.

In there article which was found HERE (ABC News), one of the pictures say that Tiffanie gained 10 inches in height (not shown below). In another section of the article the writer says TIffanie had 14 inches in gained height but they also state that she increased height from 3’6″ to 4’10”, which is not 14, but 16 inches in height difference. This either shows that the writer and journalist was misinformed or really bad in math, forgetting to account for the far that 1 feet is not 10 inches but 12 inches.

Little Person No More