this is a research proposal by Janvi Rautela from Univeristy Of Toronto that looks like it’s going to be doing LSJL like loading on dwarf rats.

Measuring the efficacy of meclozine plus weight loading compared to that of surgical limb lengthening in Mus musculus species born with skeletal dysplasia: achondroplasia

“Invasive or noninvasive treatment is the question patients frequently ask themselves when deciding upon medical procedures. This paper investigates the question by comparing strengths of both options in reducing the skeletal deformity, achondroplasia (Ach), caused by mutation of the FGFR3 gene. The research employs two variables: age and various treatments, to identify which developmental period is most responsive to the prescribed procedures, in diminishing the physical symptoms of Ach. By combining the emerging Ach treatments and contrasting their effects, researchers can branch to new unventured domains of viable alternatives to traditional treatments.”

“the FGFR3 gene is crucial in capping bone mass and limiting activities of bone remodeling cells: osteoblasts and osteoclasts. Thus, the phenomenon performed by the presence of this gene is required in preventing gigantism{So could we theoretically block FGFR3 to induce gigantism via a mechanism like CNP}, and mutation of the gene hyperactivates its function; thereby contributing to stunting of average height.”

“This study intends to identify which treatments: oral drug administration plus knee loading or surgical tibia lengthening, fairs better to encourage bone growth, and if the age of received treatment is of any significance.”<-knee loading is another term used for LSJL developed by Hiroki Yokota and Ping Zhang.

“loading applied to the limbs (Zhang, Hamamura, Turner, & Yokota, 2009) are more powerful”<-it’s clear that they mean this method as they cite the paper.

“1 mg of meclozine will be administered and loads with a force of 0.3 N will be placed on mice limbs once a day for 3 months for cohorts receiving the noninvasive treatment.”

“meclozine has been found to disrupt FGFR3 signaling, and thus allow for chondrocytes to proliferate, stimulate the growth of metaphyseal bones, and increase mineral content within bones. Likewise, the application of loading on the limbs motivates the elongation of endochondral bones by inducing Wnt as well as transforming growth factor-beta signaling, thereby having an effect that encourages chondrocyte production”

Janvi Rautela is definitely a researcher to watch! Hopefully this study has good results.