In a post I had written before which was entitled “Osteogenic Protein 1 OP-1 Or Bone Morphogenetic Protein 7 BMP-7 Can Increase Intervertebral Disk Height (Important)” I had shown that an injection of BMP-7 (aka OP-1) into the intervertebral disk nucleus pulposus resulted in vertebral height increase and disk regeneration.

At the time, I felt that the post was the most significant discovery of a possible way to increase height since the experiments on rabbits  who suffered disk degeneration was so effective. From just one injection of OP-1 the effect on disk regeneration and also disk height increase lasted for upwards of at least 2 weeks in all of the experiments.

What I was thinking at the time was moving from the rabbit model into the human subjects. If we took subjects who were suffering from disk degeneration and injected OP-1 into the their disks, would it result in long term effects or would we have to consistently over time keep on adding the OP-1. Plus, there were studies which showed that if you use a needle to punture the disk, you could cause complete lumbar collapse, disk lose, and other horrible problems.

Right now in my research, I was thinking of trying a more noninvasive approach which is to take capsules or implants which you can place around the said disk which has a semipermeable membrane which allows for the OP-1 to only diffuse in one direct from a concentration gradient. at this point I would guess that the intervertebral disk is made of a type of collagen fiber which is permeable. From my past with guages and biomedical application, I would be even willing to suggest trying out a patch or guass you can directly apply to your back side which can absorb the BMP-7 concentratin through the skin and reach the disk.

From this source HERE we learn that…

The discs in your spine are made up of the inner, gelatinous nucleus pulposus and the outer annulus fibrosus. This outer ring is a firm, ligament that encloses the spongey nucleus and prevents it from herniating or bulging beyond its normal perimeter, according to Jack Zigler, M.D. on the Spine-health website. The annulus also disperses the pressure on the vertebrae caused by weight-bearing activities. If the annular fibers stretch or tear, the nucleus can herniate, which may lead to back pain and sciatica.

From this source HERE we learn that…

ANNULUS FIBROSUS

The intervertebral disc is made up of two parts: the annulus fibrosus and the nucleus pulposus. The annulus fibrosus is the outer layer of the disc that encompasses the gel-like nucleus pulposus inside the disc. Made of strong layers of collagen fibers woven together at varying angles, the annulus fibrosus gives structure to the disc and allows for even weight distribution of surrounding vertebrae.

Though designed to endure relatively great amounts of pressure, over time the annulus fibrosus begins to lose flexibility and elasticity, leaving it vulnerable to damage. A weakened intervertebral disc can begin to “bulge,” causing a bubble of nucleus pulposus material to protrude in the outer layer. In some cases, a bulging disc can turn into a herniated disc, which is when the annulus fibrosus wall completely ruptures and releases nucleus material into the spinal canal. Depending on the amount of disc material placing pressure on the spinal cord and nerve roots, symptoms can range from mild to severe.

While intervertebral disc damage is often a result of aging and normal wear and tear to the spine, there are steps you can take to mitigate it. Exercising and maintaining a healthy body weight will help ensure your spine is adequately supported and decrease the amount of pressure placed on the annulus fibrosus of each disc. Since cigarette smoking decreases the amount of water in the discs, it can actually cause discs to degenerate faster, so you also should avoid smoking. Finally, maintaining correct posture and using proper body mechanics when lifting, exercising, or sleeping will minimize your chances of developing a disc problem.

This picture taken from Wikipedia link HERE .

What is important to note is that the back is not completely made of irregular vertebrate bone. There are the areas of disks which we might be able to manipulate.

The disk annulus is made of collagen fibers that seems to connect at an angle. The composition is a lot of water. If the disk is permeable of a certain we should be able to get salt into it using a concentration gradient, and then use water into the disk through another semipermeable gradient that only allows water to go through.

I had stated in a recent post that the BMPs were the most viable path to look into at this point of the research for a height increase technique. The studies and research have shown that this type of protein, which is in the family of TGF-β cellular proteins is very effective in spinal fusions of fractures.

Source 1 – Title “Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits.”

Spine (Phila Pa 1976). 2005 Jan 1;30(1):25-31; discussion 31-2.

An HS, Takegami K, Kamada H, Nguyen CM, Thonar EJ, Singh K, Andersson GB, Masuda K.

Source
Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, Illinois, USA.

Abstract

STUDY DESIGN:
A study of the disc height and biochemical changes in the rabbit intervertebral disc after injection of osteogenic protein-1 into the nucleus pulposus.

OBJECTIVES:
To evaluate the in vivo effects of osteogenic protein-1 administered intradiscally to the intervertebral disc of rabbits.

SUMMARY OF BACKGROUND DATA:
Growth factors, such as osteogenic protein-1 and transforming growth factor-beta, have the ability to stimulate synthesis of proteoglycan and collagen in vitro. No attempts have yet been made to determine the effects of these growth factors in an in vivo model.

METHODS:

Twenty-four New Zealand adolescent white rabbits were divided evenly into two subject groups. In one group, three consecutive intervertebral discs were injected with saline; whereas in the other group, they were injected with osteogenic protein-1 in saline. At 2, 4, and 8 weeks after the injection, the intervertebral disc heights of the injected specimens were measured by lateral plain radiographs and compared with preinjection measurements. The change in disc height was expressed as the percent disc height index compared with the preinjection value. After the radiographic measurements were obtained, the intervertebral discs were removed and analyzed for DNA, proteoglycan, and collagen contents.

RESULTS:

At 2 weeks after the injections, the mean disc height index of the osteogenic protein-1-injected discs was 15% greater than that of the saline group. The increase in disc height with osteogenic protein-1 injection was still statistically significant at the 4- and 8-week time points. The proteoglycan content of the nucleus pulposus in discs injected with osteogenic protein-1 was higher than that in the saline group at the 2-week time point. The osteogenic protein-1-induced effect on the proteoglycan content was also present at the 4- and 8- week time intervals; however, these increases were not statistically significant. There were no significant differences in the DNA content, normalized to noninjected control, of the nucleus pulposus between the saline and osteogenic protein-1 groups. However, a significant increase in the DNA content of the anulus fibrosus in the osteogenic protein-1 group, compared with that of the anulus fibrosus in the saline group, was observed after 4 weeks.

CONCLUSION:

To date, no study has demonstrated the potential in vivo effects of growth factors on the intervertebral disc. The present study reports that the intradiscal administration of osteogenic protein-1 in vivo results in an increased disc height present at 2, 4, and 8 weeks and an increase in PG content of the nucleus pulposus at the 2-week time point. Therefore, osteogenic protein-1 may act to stimulate metabolic activity in the nucleus pulposus. Continued research is needed to evaluate the potential of growth factor-induced reversal of age-related disc degeneration in an appropriate animal model. In addition, studies in a nonhuman primate animal model will be essential before considering intradiscal injection of growth factors in humans.

PMID: 15626976       [PubMed – indexed for MEDLINE]

Source 2 – Title “Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model.”

Spine (Phila Pa 1976). 2006 Apr 1;31(7):742-54.

K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, Thonar E, Andersson G, An HS.

Source
Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL, USA. kmasuda@rush.edu

Abstract

STUDY DESIGN:
In vivo study of the effect of injection of osteogenic protein-1 (OP-1) on a rabbit anular needle puncture model of intervertebral disc (IVD) degeneration.

OBJECTIVE:
To study radiographic, magnetic resonance imaging (MRI), biochemical, and histologic changes in the rabbit IVD after injection of OP-1 into the nucleus pulposus in a needle puncture disc degeneration model.

SUMMARY OF THE BACKGROUND DATA:
Growth factors, such as OP-1, have the ability to stimulate synthesis of proteoglycans and collagen in vitro. The in vivo injection of OP-1 into the normal rabbit IVD has increased disc height and proteoglycan content in the anulus fibrosus and nucleus pulposus. However, to our knowledge, no attempts have yet been made to determine the effects of these growth factors in an in vivo model of disc degeneration.

METHODS:
New Zealand adolescent white rabbits (n = 90, 8 for baseline evaluation, 82 at 8 times) received an anular puncture in 2 noncontiguous discs with an 18-gauge needle to induce disc degeneration. Four weeks later, either 5% lactose (10 microL) or OP-1 (100 microg in 10 microL 5% lactose) was injected into the center of the nucleus pulposus. The disc height was followed radiographically for up to 24 weeks after the injections. At the 2, 4, 8, 12, and 24-week times after the injection, rabbits were euthanized, and MRI of the harvested spinal columns was obtained to grade the degeneration. The discs injected with OP-1 or lactose and noninjected discs were subjected to biochemical and histologic analysis. The specimens at the 24-week time were limited to histologic evaluation.

RESULTS:

The anular puncture with a needle induced a consistent disc narrowing within 4 weeks. The injection of OP-1 induced a restoration of disc height at 6 weeks, which was sustained for the entire experimental period, up to 24 weeks after the injection. The injection of lactose alone did not change the course of disc narrowing over the same time. MRI grading score showed significant differences between the OP-1 and lactose groups at the 8, 12, and 24-week times, suggesting an increase in water content in the nucleus pulposus of the OP-1 group. The proteoglycan content of the nucleus pulposus and anulus fibrosus was significantly higher in the OP-1 group than in the control group. The degeneration grades of the punctured discs in the OP-1 group were significantly lower than those in the lactose group.

CONCLUSION:

The results of this study show the feasibility of restoring degenerative rabbit discs by a single injection of OP-1 into the nucleus pulposus. Importantly, the effects of the OP-1 injection on disc height were sustained for up to 24 weeks. The metabolic changes in the cells, following a single injection, might be sustained and, thus, induce long-term changes in disc structure. An efficacy study in large animals is required to show further that the intradiscal injection of OP-1, or bone morphogenetic proteins or growth factors with similar properties would be useful for the structural restoration of the IVD in humans.

PMID: 16582847     [PubMed – indexed for MEDLINE]

Source 3 – Title “Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC.”

Spine (Phila Pa 1976). 2007 May 15;32(11):1197-205.

Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC.

Imai Y, Okuma M, An HS, Nakagawa K, Yamada M, Muehleman C, Thonar E, Masuda K.

Source<
Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA.

Abstract

STUDY DESIGN:

In vivo study of the effect of an injection of recombinant human osteogenic protein-1 into degenerated discs induced by chondroitinase ABC.

OBJECTIVE:

To investigate the efficacy of an injection of recombinant human osteogenic protein-1 to induce the recovery of disc height, and biochemical and histologic repair, in discs degenerated through enzymatic digestion by chondroitinase ABC.

SUMMARY OF THE BACKGROUND DATA:

Chondroitinase ABC is currently proposed as a chemonucleolysis agent; however, postchemonucleolysis degeneration is currently unavoidable. Recombinant human OP-1 has been shown to promote extracellular matrix repair in vitro and in vivo.

METHODS:

Fifty-four adolescent New Zealand white rabbits were used. Four weeks after an initial injection of chondroitinase ABC (10 mU/disc), 5% lactose (10 microL/disc) or recombinant human osteogenic protein-1 (100 microg in 10 microL lactose/disc) was injected. Disc heights were monitored radiographically at 2-week intervals, and rabbits were killed at 6, 8, 12, and 16 weeks after the initial chondroitinase ABC injections. The intervertebral discs were subjected to histologic and biochemical analyses.

RESULTS:

Significant disc space narrowing was observed in both groups 2 weeks after the injection of chondroitinase ABC. In the chondroitinase ABC/lactose group, this narrowing progressed after the vehicle injection and was sustained for up to 16 weeks. In the chondroitinase ABC/recombinant human osteogenic protein-1 group, the disc height index showed a significant increase at 6 weeks (lactose vs. recombinant human osteogenic protein-1; P < 0.01); this recovery was sustained for up to 16 weeks. The proteoglycan content was higher in the chondroitinase ABC/recombinant human osteogenic protein-1 group than in the chondroitinase ABC/lactose group. However, histologic changes, after the recombinant human osteogenic protein-1 injection, were not observed.

CONCLUSIONS:
A single injection of recombinant human osteogenic protein-1 into a rabbit disc dramatically reversed the decrease in disc height induced by chondroitinase ABC chemonucleolysis. The recovery was significant and sustained over the next 12 weeks. The therapeutic effects of both chondroitinase ABC chemonucleolysis and recombinant human osteogenic protein-1 injections should be further explored in higher animals before it is applied to humans.

PMID: 17495776     [PubMed – indexed for MEDLINE]

Me: Tyler from HeightQuest wrote a similar article HERE about the studies which shows the effects of using OP-1 aka BMP-7 on the intervertebral disk height.

What I am not sure of is the first passage which he takes. are the subjects in the experiment rabbits, sheep, or humans?? However, the results are very clear. using GDF-5 (I have got to do a post about this compound protein!!) and OP-1 injected into the disks increased the nucleus pulpous cell types and the collagen, which suggest less compression in the vertebrate area (thus more height, even if it is only a few millimeters) and more elasticity.

His next section about the sheep show incredible results which showed that growth plates were increased from  using recombinant OP-1. I quote this passage “”…treatment with rhOP-1 initiated a complex response that was both chondrogenic and osteogenic in nature”

The next part shows that the BMP-7/OP-1 also leads to Collagen type II and Proteoglycan synthesis increase so this protein is absolutely critical. I am willing to bet that getting the mesenchymal stem cells to differentiate into chondrocytes will only assist in the bone formation process.

Conclusion: This is one of those articles that comes out that creates a whole new pathway to look at and pushes the possibility go height increase further along. With this type of study, I am willing to bet that scientific researchers will find a way to increase height in adult within 10-15 years if they are willing to take some big risks and try a few dangerous experiments on human subjects. The next article will be a complete and full explanation of the facts and information found here. The results are amazing.

This is one of those stories and anecdotes that you should hear to understand just what is going on the world today, and especially of the US population in today’s modern times. This is a story about height.

About 3 and a half years ago right after I was laid off from my first corporate job after getting out of college, I found myself in one of the worst economic recessions that the US has ever seen. It was in the spring time and the leaves were finally blooming after a rather easy winter of milk weather. I decided that instead of battling it out against the other job seekers that had lost their jobs in the 2008-2009 time, I would take a road trip that I have always wanted to go on.

During my days in college, I had always wanted to go to the great midwest of the US and see what lied in that area. So about 1 week after I was laid off, I put some stuff in my car and took off for a trip that would last over 9 days, 4500 miles, and some great stories.

The path I took went like this Washington -> Idaho -> Montana – > North Dakota -> Minnesota -> Iowa -> Nebraska -> Utah -> Wyoming – > Idaho -> Oregon -> Washington.

I traveled from the west to the middle and back to the west again. In that time, I DEFINITELY noticed some major differences in the demographic of the towns and populations I passed.

The first thing I noticed is that as you go more towards the middle states, the towns move more towards the side of caucasians or native americans. In one Walmart in Minnesota, I was one of only two people who was non-caucasian. It was a very enlightening experience. The major thing I noticed about the people was that by the time I had reached the North Dakota area, the people I saw when I stopped either to use the bathroom or got gas seemed to get taller and taller.

I remember one stop I took either in North Dakota or Minnesota (probably Minnesota close to St. Cloud) where I noted that every single guy in a fast food stop was taller than me, even when I was wearing thick heeled boots. The height and size of these people were very noticeable.

I remember getting out to get gas when I drove up to Duluth, Minnesota and finding that the gas station worker was almost 6’7″. When I went to eat at a local buffet, the man who strode to the restaurant in front of me was probably a 6′ 9″ giant who didn’t seem all out of place in the city. I saw many families eating and I seemed like many of the adult men were taller than me.

When I finally left Minnesota, I drove down south to Iowa and I stopped by Cedar Springs at a local Walmart. It was there that I was greeted by a Subway Sandwich maker who was probably 6′ 8″ and I decided to sit down and just watch the people walk by. I made a specific point to note the people who were buying things and using the checkout counter. Every single man at that Walmart was taller than me, which would have put them at least 6′ 3″ or taller. I watched maybe 30 men pass through the checkout counters while I was eating my sandwich and not one was shorter than me.

When I decided to do some shopping and buy some provisions for the drive ahead, I saw who I still claim to this day is the tallest person I have ever seen in my life! 

Now, in my life I have lived in many areas of the US and I have seen my share of tall people. I have definitely seen at least 1 dozen 7 footers, once I realized that the top of most doorways in commercial building are at the 7 feet mark. I have seen many guys duck their head when they have to walk through a door way. At one point, I am almost positive I was seeing 1 footer every 6 weeks, at least last year around the Seattle area where I was living. I couldn’t understand why there was so many giants all of a sudden. It’s not like I go out a lot and see many people.

I have run in marathons before and have been to state fairs. There is always a few really tall guys but they rarely get past the 6’7″-6’8″ mark. All of a sudden last year to the beginning of this year, I started noticing that a lot of really tall 7 foot men were around.

Getting back to the story, that man I saw in a Walmart in the city of Cedar Springs Iowa was amazingly tall. I swear that from about 30 feet away, he looked like he was about 7’2-7’3″, taller than even Shaq. The even more amazing thing was that this men was slouching a lot. He looked like he was in his 70s or 80s, with a curved back, and his grandson was walking right along side of him.

I had to leave to get back to my car but I remembered just his amazing size. Everyone at that Walmart was huge but this guy who was slouching was the biggest. From far away he looked like a true giant. If he was at his prime and stood up completely straight, I would say he would probably be around the 7′ 5″-7’6″ mark. I am not joking about this.

After that incident, I never noticed many other giants on that trip. However, that one stop in Iowa has forever burned into my mind an image of what people from the Midwest are like. They are big. Now, am I going to make the statement that caucasian people are taller than other ethnicities? From my observation in that trip, I would say there is a strong correlation.

The other story I wanted to share was one time I was at a Mall in a small town in Southern Idaho. As I was walking through the mall, I noticed what appeared to be young high school boys dressed very sharply for a formal event, probably a prom or dance or something. I noted that a group of these high school boys standing in a circle and laughing at something rather childish like most High School guys (I was in college at that time so I can say something like that). In that group, it was all white caucasian guys who were all very tall, some around the 6’3″-6’4″ range, and one asian male, I would guess Chinese, who was the only short one of the group who appeared to be around 5′ 7″-5’8″.

These two stories are the only examples that I can come up from which in my memory really stood out. From just these two stories, I have sort of formed already a generalization that it really does appear that certain ethnicities or races are just taller and bigger than others, and I would guess genetics have a lot to do with it. For me, It felt like that as I drove more and more into areas of the USA where the majority of people were “white” the taller and taller the populations and people seemed to be.

I don’t know what you want to take out of this anecdotal story but maybe you found some entertainment or insight from it.

I somehow found this graph of the average height of males of the US heights compared to the average male heights of the Europeans looking at the height differences of the last 150 years that have passed. The link/ resource I found this very illustrative graph from is HERE.

Just today while I was doing research on the fact that at least two types of animal species have been found to be biologically immortal, meaning they don’t older, I stumbled upon the story about Brooke Greenberg, who at this time is a 19 year old female but appears to have not grown older through the years. Her anthropomorphic measurements are just about 30 inches (76 cm) tall, weighs about 16 pounds (7.3 kg) which is about the usual size of a 1 year old. Her physical and mental maturity seems to not have progressed at all.

Her story was really big a few years ago when ABC News did a story on her.

From the Wikipedia article on her HERE….

Brooke Greenberg (born January 8, 1993), is an American from Reisterstown, Maryland, who has remained physically and cognitively similar to a toddler, despite her increasing age. She is about 30 inches (76 cm) tall, weighs about 16 pounds (7.3 kg), and has an estimated mental age of nine months to one year. Brooke’s doctors have termed her condition Syndrome X.

Brooke was born on January 8, 1993 at Sinai Hospital in Baltimore, Maryland, one month prior to her due date, weighing just four pounds (1.8 kg). She was born with anterior hip dislocation, a condition which caused her legs to be swiveled upwards toward her shoulders; this was corrected surgically. Otherwise, Brooke appeared to be a normal infant.

Birth and early life

In her first six years, Brooke Greenberg went through a series of unexplained medical emergencies from which she recovered. She had seven perforated stomach ulcers. She also suffered a seizure. This was followed by what was later diagnosed as a stroke; weeks later, no damage was detected. At age five, Brooke had a mass in her brain that caused her to sleep for 14 days. The doctors diagnosed the mass as a brain tumor. However, Brooke later awoke, and physicians found no tumor present. Brooke’s pediatrician, Dr. Lawrence Pakula, states that the source of her sudden illness remains a mystery.

To keep food from getting into her lungs, Brooke is fed through a permanent stomach tube. Feeding her through the tube takes ten hours a day.

Unexplained condition

Over the past several years, the Greenbergs visited many specialists, looking for an explanation for their daughter’s strange condition, yet there has been no diagnosis of any known genetic syndrome or chromosomal abnormality. In 2001, when Dateline documented Brooke, she was still the size of a six-month-old infant, weighing just 13 lb (5.9 kg) at 27 inches (69 cm) tall. The family still had no explanation. Brooke Greenberg’s mother Melanie said, “They [the specialists] just said she’ll catch up. Then we went to the nutritionist, the endocrinologist. We tried the growth hormone…”. The growth hormone treatment had no effect. Howard, Brooke’s father, said: “I mean she did not put on an ounce or she did not grow an inch … That’s when I knew there was a problem.” After the growth hormone administration failed, the doctors, unable to diagnose a known condition, named her condition Syndrome X.

The Greenbergs made many visits to nearby Johns Hopkins Children’s Center, and even took Brooke to New York’s Mount Sinai Hospital, searching for information about their daughter’s condition. When geneticists sequenced Greenberg’s DNA, they found that the genes associated with the premature aging diseases were normal, unlike the mutated versions in patients with Werner syndrome and progeria.

Medical studies

In 2006, Richard Walker, PhD in endocrine physiology of the University of South Florida College of Medicine, said that Brooke’s body is not developing as a coordinated unit, but as independent parts that are out of sync. She has never been diagnosed with any known genetic disorder or chromosomal abnormality that would help explain why. Her telomeres seem to be shortening at the normal rate.

In 2009, Walker said: “There’ve been very minimal changes in Brooke’s brain … Various parts of her body, rather than all being at the same stage, seem to be disconnected.” Walker noted that Greenberg’s brain, for example, is not much more mature than that of a newborn infant. He estimates her mental age at around nine months to a year old. Brooke can make gestures and recognize sounds, but cannot speak. Her bones are like those of a ten-year-old, and she still has her baby teeth, which have an estimated developmental age of about eight years. Said Walker, “We think that Brooke’s condition presents us with a unique opportunity to understand the process of aging.”  “Different parts of her body are developing at different rates, as if they were not a unit but parts of separate organisms,” Walker explains.

Dr. Walker believes that the condition resulted from a failure of central control genes. He has identified two more people with similar developmental issues: Gabrielle Williams of Montana (born 2004) and Nicky Freeman of Australia (born 1970), a forty-year-old man who looks like a boy. Others, such as British biologist Aubrey de Grey, believe that aging and development are not related.

Me: What is fascinating about this story is that even the geneticists are perplexed by wha they are seeing. this girl is not suffering from the ordinary genetic issues like Werner syndrome or progeria. It states that “She has never been diagnosed with any known genetic disorder or chromosomal abnormality that would help explain why. Her telomeres seem to be shortening at the normal rate.” It would appear that she is growing and gaining weight and may be going through the process but the rate at which she is aging and changing is extremely slow. The incident where she developed a brain tumor that went away after a few weeks is ridiculous. At the end of the wikipedia article, I noted the statement that “aging and development are not related”. That is definitely a challenged to what most people would think is so self evident that is common sense but from a scientific point of view makes sense. Aging and development don’t always have to go together, it may just appear from the outside in a phenotypical way to be the same thing. Maybe there are people like Brooke which do age, but don’t develop. They even did a documentary on her entitled ‘Girl Frozen In Time” that aired on TLC.

As for any height increase related news, the doctors did try to put her on a growth hormone therapy but she didn’t gain any height or even weight. Now that is ridiculous. They stated that her body is not developing at the same rate, but separately. 

From ABC News 20/20 website HERE…

Doctors Baffled, Intrigued by Girl Who Doesn’t Age

Something I have read about in the Giant Scientific forum and the Impartial Height Board discussion was the talk of using other types of steroid to possibly inhibit the aromitization factor of estrogen just like previously looked at compounds like anavar. I know at least one person who decided to incorporate these compounds into their routine as a type of multivitamin supplement to possibly increase the GH release rate or slow down the rate of growth plate senescence.

this next part was taking from the Anabolic Minds forums located HERE, on the same post where people talked about the possibility of using GHenerate and I-GH-1 in possibly increasing height.