Fibrillin I Gene Polymorphism Is Associated With Tall Stature Of Normal Individuals

This will be a rather short post because the subject or topic I wanted to talk about does not have the full article listed, at least without me paying for it. I can not do a proper review or analysis on the study or paper.

I found a published article that links the polymorphic nature of the Fibrillin I gene with tall stature in normal humans. The theory being tested was that the different forms that can develop from the Marfan syndrome gene (which is the FBN1) might affect the stature or height of even normal people, not just people who do suffer from Marfan Syndrome.

You can find the link to the abstract and full text on the PubMed website by clicking HERE. The very short abstract is copy and pasted below.


Hum Genet. 2007 Jan;120(5):733-5. Epub 2006 Sep 26.

Fibrillin I gene polymorphism is associated with tall stature of normal individuals.

Mamada M, Yorifuji T, Yorifuji J, Kurokawa K, Kawai M, Momoi T, Nakahata T.

Source

Department of Pediatrics, Kyoto University Hospital, 54 Shogoin Sakyo, Kyoto 606-8507, Japan.

Abstract

In order to test the hypothesis that polymorphisms of the Marfan syndrome gene (FBN1) might affect the stature (height) of normal individuals, we genotyped three exonic SNPs on 428 males, 219 with tall stature (>2 SD) and 209 with normal stature (within +/-1 SD). One of the SNPs, rs8033037, in exon 15 showed a significant correlation (P = 0.0061) with the adult height, suggesting that FBN1 is one of the ‘stature genes’ of normal individuals.

PMID: 17024364 [PubMed – indexed for MEDLINE]

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