This idea is also completely new to me since I never realized that L-Dopa could have such an affect. I first learned about L-Dopa only last year when I was sitting in on a neurobiology course where I learned about the anatomy, physiology, and mechanics of how the brain works. L-Dopa was supposed to be a precursor to dopamine, norepinephrine, epinephrine, which is a precursor to tryptophan.
I forgot a lot about the effect of L-Dopa so I went to Wikipedia to refresh my memory on what it does (Source)
L-DOPA (L-3,4-dihydroxyphenylalanine) is a chemical that is made and used as part of the normal biology of some animals and plants. Some animals including humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), andepinephrine (adrenaline) collectively known as catecholamines. L-DOPA can be manufactured and in its pure form is sold as a psychoactive drug with the INN levodopa; trade names include Sinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa, etc.). As a drug it is used in the clinical treatment of Parkinson’s diseaseand dopamine-responsive dystonia.
L-DOPA crosses the protective blood–brain barrier, whereas dopamine itself cannot. Thus, L-DOPA is used to increase dopamine concentrations in the treatment ofParkinson’s disease and dopamine-responsive dystonia. This treatment was originally developed by George Cotzias and his coworkers. Once L-DOPA has entered the central nervous system, it is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase, also known as DOPA decarboxylase (DDC).Pyridoxal phosphate (vitamin B6) is a required cofactor in this reaction, and may occasionally be administered along with L-DOPA, usually in the form of pyridoxine.
Besides the central nervous system, L-DOPA is also converted into dopamine from within the peripheral nervous system. The resulting hyperdopaminergia causes many of the adverse side effects seen with sole L-DOPA administration. To bypass these effects, it is standard clinical practice to co-administer (with L-DOPA) a peripheral DOPA decarboxylase inhibitor (DDCI) such as carbidopa (medicines combining L-DOPA and carbidopa are branded as Lodosyn, Sinemet, Parcopa, Atamet, Stalevo) or with a benserazide (combination medicines are branded Madopar, Prolopa), to prevent the peripheral synthesis of dopamine from L-DOPA. Co-administration of pyridoxine without a DDCI accelerates the peripheral decarboxylation of L-DOPA to such an extent that it negates the effects of L-DOPA administration, a phenomenon that historically caused great confusion.
In addition, L-DOPA, co-administered with a peripheral DDCI, has been investigated as a potential treatment for restless leg syndrome. However, studies have demonstrated “no clear picture of reduced symptoms”.
The two types of response seen with administration of L-DOPA are:
- Short-duration response, which is related to the half-life of the drug
- Longer-duration response, which depends on the accumulation of effects over at least two weeks. This response is evident only in early therapy, as the inability of the brain to store dopamine is not yet a concern.
Herbal extracts containing L-DOPA are available. The most common plant source of L-DOPA marketed in this manner is Mucuna pruriens (velvet bean). The important amino acid called Tyrosine is a precursor to Levodopa and is also available over the counter. This supplement converts into Dopamine, Norepinephrine and Epinephrine as well.
L-tyrosine by the enzyme tyrosine hydroxylase (TH). It is also the precursor for the monoamine or catecholamine neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). Dopamine is formed by the decarboxylation of L-DOPA.
L-DOPA can be directly metabolized by catechol-O-methyl transferase (COMT) to 3-O-methyldopa (3-OMD), and then further to vanillactic acid (VLA). This metabolic pathway is non-existent in the healthy body, but becomes important after peripheral L-DOPA administration in patients with Parkinson’s Disease or in the rare cases of patients with aromatic L-amino acid decarboxylase (AADC) enzyme deficiency.
The prefix L– references its property of levorotation (compared with dextrorotation or D-DOPA).
L-Phenylalanine, L-tyrosine, and L-DOPA, are all precursors to the biological pigment melanin. The enzyme tyrosinase catalyzes the oxidation of L-DOPA to the reactive intermediate dopaquinone, which reacts further, eventually leading to melanin oligomers.
Me: All that you need to know is that there is a supplement Tyrosine, which can convert into L-Dopa after you take it. However, we need to understand why and how L-Dopa has been theorized can help a person increase their height.
From this HERE anti-aging site, they state very clearly …
“””It has been known for over 30 years that it is an effective stimulant of human growth hormone (HGH) release.”””
So what we see is that L-Dopa can be used to increase the release of HGH by the pituitary, resulting in possible height increase, and physiological anti-aging properties. What is even more amazing after this was what came next.
“”“Hayek and Crawford reported that six out of seven “constitutionally short children” responded to oral L-dopa (200-500mg), “…with elevations in HGH concentration above 7mg/ml, peak levels occurring between 30 and 120 minutes after drug administration..”.””
So apparently the drug was administered by researchers decades ago to see whether they can increase the growth process and height of children which were genetically short. People understood that this could probably be used to increase height. The link suggest you take 500 mg oral of L-Dopa to see an effect of HGH release.
As stated again….
“”The preceding studies illustrate some of the studies showing that 500mg oral L-dopa is an effective stimulator of HGH release. Whether a person is male or female, young or old, diabetic or not, thin or obese (possibly with Propranolol), a PD patient or not, L-dopa is a natural HGH-releasing agent when taken on an empty stomach. For those who can’t afford HGH injections, or just don’t like self-injecting,L-dopa may provide a reasonable alternative.”””
Me: THIS IS FUCKING HUGE!!! This means that even if we as physically mature adults can’t use this, we can theoretically give this to our kids and help them add height without going for the more painful and expensive HGH therapy approach. It is supposed to be safe because it is a naturally created amino acid from out own brains and body.
One thing to note is that in general, L-Dopa has been used for the treatment of Parkinson’s Disease. It can be used for only a short time to stave off the effects of the myelin in our axons from disappearing, but once the body and neurons develop a tolerance of the effects of L-Dopa it stops working too since the progress of myelin sheath digeneration only continues to get worse.
From HGH Talk we learn that “…And two good sources of L-dopa are velvet beans (Mucuna pruriens) and broad beans (also called fava beans)”. I guess you might want to start eating a lot of beans to get the HGH going.
When I do a search on google with the phrase “l-dopa height” or “l-dopa height increase” the results are quite fascinating. and I mean INSANE results.
From one of the only credible height increase boards, the Impartial Height Increase Boards, from this discussion, the poster writes…
Well I have been taking 600 mg. L-Dopa along with 10 grams L-Arginine before bed for about 2 weeks. I am very pleased with the results that I have gained with this combination. And so far no side effects, and I do not think I will see any side effects. Well anyway the first week I started taking it I immediately noticed my feet were getting larger, and my slip on shoes did not fit me anymore after about 5-6 days. So then I started to realize how powerfull this combination really was. Well before I started with this stack I measured at 5’7, and now I am about 5’8. So I have gained a solid inch, and expecting to keep gaining more height. I also noticed another amazing thing for me was that my muscle mass and strength were increasing which is great for me because I am very into lifting. I lift real hard and heavy everyday to get bigger and stronger for football. I think so far this stack is taking my athletic performance to another level by increasing my height, and muscle mass. I am very pleased, and I will keep you guys posted in the next few weeks.
Me: So after two week of taking L-Dopa in combination with L-Arginine the guy increases by 1 inch!! Of course I don’t know how old this guy is and whether his plates are fused but even if it is not, I can bet you money that when I have kids, I am going to feed them a lot of fava beans and velvet beans.
The Dosage is 600 mg of L-Dopa with 10 g of L-Arginine before bed. The dosage is high and the other posters have said that it has some bad side effects and can lead to death. I say it is worth really looking into, even if it can cause death. In my opinion, this type of venture will always be filled with danger. You do have to break a few eggs to make a cake. The product is named “HGH Dopa 400”. It’s sold on many online stores.
One poster does note…
“”Very short kids are treated with HGH injections this works
because HGH goes straight into the bloodstream no problems with inhibiting factors of the liver,also Gonadotrophines (secreted by the Puitary Gland) still don’t play a role.When they do (Gonadotrophines),they stimulate your testicles to produce Testosterone,some growspurts will occur(very whimsical patterns differ from person to person,matter of genes)after that your bones are going to fuse also mainly caused by Testosterone (to make it not too complicated),end of story.(no further natural HI)””
Conclusion: This post is sort of a breakthrough post since it just created a completely new path in maybe naturally increasing our HGH release rate. It has been used on short statured children, and I will probably be feeding my future children with broad beans, velvet beans, and fava beans by the truckload if another easier way to increase height is not found in 10 years. They are going to have bean nightmares.