Bioengineered Cartilage Pellets And LIPUS For Longtitudinal Growth (Huge Breakthrough!)

Me: This is one of the only studies I’ve found so far which seems to be talking about the exact same thing we at this website have bene talking for the longest time. I know that this article has been looked at by Tyler on HeightQuest.Com HERE and I have looked at his analysis and critique very thoroughly since this study is as close to a real study on height increase as I have found so far. It has also been looked at on other height increase forums. I can’t find the complete article but Tyler seemed to have more than me.

This article is fascinating since it would appear that the rabbits actually had their leg bones fractured, then had both a bioengineering cartilage pellet, and the LIPUS technology administered.

Huge Breakthrough 1: The study states conclusively that if we decided to use a height increase method which involved distraction, using the LIPUS technology doesn’t help. Very useful tip here. Tyler argues over the mechanics about whether they might have administered it wrong but let’s assume these Ph. Ds knew what they were doing for the time being.

Huge Breakthrough 2: The study showed that a bioengineering chondrocyte pellet was implanted in an induced distraction/fracture area. This means that somehow these group of researchers from Hong Kong have finally actually managed to completely grow a growth plate cartilage in vitro which works. The reasoning I wanted to use is this. I thought from the previous post that these researchers could only develop hyaline cartilage but this study showed that they hav also been successful in making growth plate cartilage. if you tried implanting just ordinary hyaline cartilage in growth plate physis fracture you would not get the same type of longitudinal growth because their is no perichondrium with the blood vessels going through it. You need to have a functional growth plate to allow for that type of increase in longitudinal growth, which some thing like an articular cartilage extract would not be able to do.

Implications: This shows the first real non limb-lengthening procedure for bone lengthening ever. I know that some people might want to disagree since this is just an implant into the physeal (growth plate) injury but I am extremely confident that what the researchers have done is create a synthetic, immunologically non-resistant growth plate which can be implanted back into bone and grow.

[I would be willing to guess that the growing process they use to do the growth pellet formation was from this study HERE, which Tyler also cited in the same article post from february of 2012 which I linked above. And I have the complete study article on my post. ]


From PubMed study link HERE

J Biomed Mater Res B Appl Biomater. 2011 Oct;99(1):36-44. doi: 10.1002/jbm.b.31869. Epub 2011 Jun 16.

Restoration of longitudinal growth by bioengineered cartilage pellet in physeal injury is not affected by low intensity pulsed ultrasound.

Chow SK, Lee KM, Qin L, Leung KS, Cheung WH.

Source

Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

Abstract

Physeal fracture is a common pediatric fracture that would result in premature physeal closure in long bones, and there is currently no gold standard for its management. In this study, we investigated the application of a Bioengineered Cartilage Pellet (BCP) in repairing a rabbit physeal fracture model, and the possible effects of Low Intensity Pulsed Ultrasound (LIPUS) treatment. Rabbits with physeal fracture created were assigned to the NC group (no BCP, no LIPUS), GC group (BCP, no LIPUS), and GT group (BCP and LIPUS). Femoral lengths and cartilage area were assessed at 4, 8, and 16 weeks post-defect. After transplantation, the BCP showed continuous growth in the host and demonstrated resemblance to a natural growth plate. The GC group showed 34.1, 32.1, and 41.1% advantage in lengthening over the NC group and the GT group showed 51.1, 41.6, and 26.9% improved lengthening than the NC group, at 4 (p = 0.203), 8 (p = 0.543) and 16 weeks (p = 0.049), respectively. Cartilage area was shown to be significantly higher in GC and GT group compared to NC group (p < 0.05). No significant difference was found between GC and GT group. Femoral longitudinal growth was shown to be improved by the BCP, however no additional enhancement effect was shown to be provided by LIPUS.

Copyright © 2011 Wiley Periodicals, Inc.

PMID:  21681954        [PubMed – indexed for MEDLINE]

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