In a follow up to a very recent post where I looked at the possible height increasing potential of Korean/Chinese traditional medicinal plant extracts Eleutherococcus Senticosus and Artemisia Capillaris (spelled wrong last time) entitled “Scientific Study Shows Chinese Plant Extract Eleutherococcus Senticosus And Artemisia Capillasis Infused In Kiwoomi Rice Enhanced Growth Rates” I was some searching to see if there was any more articles similar in nature and I came across a study that was entitled “Effect of combined extract of Hansogdan (Phlomis umbrosa) and Dalgaebi(Commelina communis) as a milk additive for enhancing the growth of physical heightin vivo“
From the SpringerLink database…
June 2012, Volume 21, Issue 3, pp 875-879
Effect of combined extract of Hansogdan (Phlomis umbrosa) and Dalgaebi(Commelina communis) as a milk additive for enhancing the growth of physical heightin vivo
- Jae Kyung Lee, Dong-guk Lee, Bo-Yeon Kwak, Jae Soo Kim, Kwontaek Yi
Abstract
Three different dosage groups for the mixed plant extract of hansogdan (Phlomis umbrosa) anddalgaebi (Commelina communis) (5, 25, and 100 mg/kg/day respectively) were evaluated in rats for the investigation of the enhancement of growth of physical height as a milk additive. Comparing to control group, the nose-to-tail (N-T) length was significantly increased in all treatment groups with a dose dependent manner, nose-to-anus (N-A) length was increased significantly in 25 and 100 mg/kg groups, the increase in both N-T and N-A lengths in 100 mg/kg group was almost same to that of positive group, and the femoral bone length in 25 mg/kg group was significantly increased. In result, the consumption of the mixed extract with milk could stimulate the longitudinal growth and that the addition of the mixed herbal extract into the milk could be more effective than milk itself in terms of the growth of physical height in rats.
Analysis: It seems that whatever these two compound extracts are, they have a good positive effect on the growth rate of at least young experimental rats. The key now is to find out how to obtain the Hansogdan, Phlomis umbrosa and the Dalgaebi, Commelina communis for western countries.
What I see from a quick glance is that the compound/ extract has been mentioned before, in another post I had posted a while ago entitled “A Korean Herbal Supplement Mixture To Possibly Increase Height (From HeightQuest.Com)” .
The actual scientific paper I only glanced at was entitled “Korean herbal supplement HT042 makes bones longer“ . The compound which was a Korean herbal supplement was HT042 which had 3 compounds we are seeing over and over again.
- Astragalus membranaceus
- Phlomis umbrosa
- Eleutherococcus senticosus
What is really interesting is that each of these three compounds we are seeing in other papers and databases. The actual PubMed study for the HT042 paper is entitled “The herbal formula HT042 induces longitudinal bone growth in adolescent female rats.” It is posted below…
J Med Food. 2010 Dec;13(6):1376-84. doi: 10.1089/jmf.2010.1007.
The herbal formula HT042 induces longitudinal bone growth in adolescent female rats.
Source
Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.
Abstract
The effect of HT042, a blend of three herbal extracts, on longitudinal bone growth was investigated in short- and long-term rat models. In the short-term model, we divided female Sprague-Dawley rats (3 weeks old) into six groups, according to treatment: vehicle, HT042 (100 mg/kg), Phlomis umbrosa (100 mg/kg), Astragalus membranaceus (100 mg/kg), and Eleutherococcus senticosus (100 mg/kg) were administered twice daily, and recombinant human growth hormone (rhGH) (1 IU) was subcutaneously injected once daily. Treatments were maintained for 4 days in each case. On day 3, tetracycline (20 mg/kg) was injected intraperitoneally (20 mg/kg) to form the fluorescent band on the growth plates. On days 2-4, 5-bromo-2′-deoxyuridine (BrdU) (50 mg/kg) was injected intraperitoneally to label proliferating cells. On day 5, the tibias were dissected and fixed in 30% sucrose. Dehydrated bone was sectioned at a thickness of 40 μm and observed. The bone growth in groups administered HT042 and rhGH was significantly increased to 433.50 ± 21.61 and 434.49 ± 15.21 μm/day, respectively, from 410.03 ± 17.4 μm/day (control). The height of the growth plates in the HT042 and rhGH groups was also significantly increased to 556.5 ± 21.1 and 544.2 ± 21.1 μm (P < .05), respectively, from 518.1 ± 4.1 μm (normal). The number of BrdU-positive cells in chondrocytes of the HT042 and rhGH groups was increased to 389 ± 36 and 627 ± 39 cells/mm² (P < .001), respectively, from 264 ± 17 cells/mm² (control). Insulin-like growth factor-1 and bone morphogenetic protein-2 in the HT042 group were highly expressed in the growth plate. In the long-term rat model, the body weight, nose-tail length, and nose-anus length were measured by microknemometry for 4 weeks. The body weight of the rhGH group was significantly increased. The nose-anus length of the HT042 and rhGH groups was significantly greater at 18.5 ± 0.3 and 18.7 ± 0.3 cm compared to 18.2 ± 0.2 cm (control).
- PMID: 21091251 [PubMed – indexed for MEDLINE]
- Analysis: While the results showed only a 3-5 mm increase for the rat groups, we can probably scale up the dosages for humans and their results would be bigger and pronounced.
- Other studies very close to this study were “Skeletal Growth and IGF Levels in Rats after HT042 Treatment.”
- Phytother Res. 2012 Dec;26(12):1771-8. doi: 10.1002/ptr.4642. Epub 2012 Mar 3.
-
Skeletal Growth and IGF Levels in Rats after HT042 Treatment.
Kim MY, Kim JY, Lim D, Lee D, Kim Y, Chang GT, Choi HY, Kim H.Source
Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea; Korea Institute of Science and Technology for Eastern Medicine (KISTEM), NeuMed Inc., Seoul, 130-701, Republic of Korea.
Abstract
HT042, a new herbal prescription consisting of Astragalus membranaceus, Phlomis umbrosa and Eleutherococcus senticosus, is used in traditional Korean medicine to stimulate growth in children. This study was conducted to investigate the effects of HT042 on skeletal growth, insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels, and oestrogenic activity in female rats. Female Sprague-Dawley rats were divided into control, recombinant human growth hormone (rhGH; 20 µg/kg/day), and HT042 (100 mg/kg/day) groups and treated for 3 weeks. Axial skeletal growth, femur length, and growth plate length were measured every 3 weeks. The serum IGF-1 and IGFBP-3 levels were analysed. Moreover, the oestrogenic activity of the herbal extracts in the immature and ovariectomized rats was tested. The nose-anus, nose-tail, femur and growth-plate lengths were increased significantly in the HT042 group. Both IGF-1 and IGFBP-3 were highly expressed in the hypertrophic zone of the growth plate. The serum IGF-1 levels were increased. Moreover, HT042 had no uterotrophic effects in the rats. Consequently, HT042 promoted longitudinal bone growth by stimulating cell proliferation in the epiphyseal plate and inducing the expression of IGF-1 without an oestrogenic response. HT042 may be helpful in stimulating growth in children with short stature. Copyright © 2012 John Wiley & Sons, Ltd.
Copyright © 2012 John Wiley & Sons, Ltd.
- PMID: 22388791 [PubMed – in process]
Conclusion: What we are finding may be one of the first real height increase herbal formulations that can really work in helping developing children to help increase height and grow taller. The side effects seem to be very little and the natural compound has great potential. So right now we have 5 big extracts that we can line up and say has high potential in increasing the growth rate of young children still growing.
- Astragalus membranaceus
- Phlomis umbrosa (Hansogdan)
- Eleutherococcus senticosus
- Artemisia Capillaris
- Commelina communis (anddalgaebi/Dalgaebi)
I’ll try to go to a local oriental medicine place and get those compounds for analysis.
Could there be any unwanted effects if all these herb extracts were taken at once? Should they be taken in a specific order/cycle?
Technically they are combined together creating certain Oriental medicine pills
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where i can buy seeds of Phlomis umbrosa?
Please, can you suggest any commercial product containing aforementioned herbal mixture that can be bought online and shiped to Serbia, Europe.