One of the few regular readers of the website Mika recently sent a message to the website email (email@example.com) showing me something which did peak my interest. It seems this Israeli Biomedical Company Bonus Biogroup has gotten the bone implant part down using the 3D Bioprinting technology. Refer to the powerpoint pdf in the link http://mayafiles.tase.co.il/
However,we have already seen maybe a dozen other companies who have been working on and gotten the functional bone tissue implantation to work out. Bone tissue implants using a stem cell into scaffold matrix model based on the standard tissue engineering process is very straight forward. I know at least 3 different university teams that have already gotten that to work.
What makes this group on Israel very interesting is that they are using 3D Printers to build the scaffold, but also plan to try to build cartilage-bone combination tissues in the future.
Mika tells me that the CEO, this Dr. Shai Meretzki, has proposed the idea of using these bone implants to help dwarves grow taller. I have not found that link or reference yet. However I did find this single passage from the following source (https://anneinpt.wordpress.com/2014/02/28/good-news-friday-90/)
Grows like any other part of the body
“This is a better solution for the body than plastic or metal pieces,” Meretzki claims. These bones are “active live bones that can grow; remodel and change as your body does.” Even with young children, when the bone graft is surgically inserted, the new addition adjusts and grows like any other part of the body.
This suggests that the bones when put into young children with functional growth plates, the bones can elongate or grow longitudinally (interstitially) along with the other part of the bone. Now, does this mean that this company already has got the Bone-Cartilage Combo working already?
What the passage is really saying is that the person still needs to have the functional growth plate cartilage in their damaged bone. The tissue implant is still only a scaffold for bone tissue, not cartilage tissue.
He still has not gotten the bone-cartilage interface to be perfected yet. What he has perfected is the bone tissue growing part. For a better explanation of the process, refer to http://jewishbusinessnews.com/2014/02/20/dr-shai-meretzki-grows-new-bones-from-patients-fat/.
He still needs a functional epiphyseal cartilage tissue with the reserve zone area to get the bone to grow on. Bone is bone. He has only been able to get the bone implants to work.
This is the next step, to get the bone-cartilage combo to be functional, which is really tricky. refer to the passage below….
“Currently,” Meretzki tells NoCamels, “we are growing bone and cartilage but we’re working on a system that combines the property of both bone and cartilage.” Hoping to break into the field of healing joints, which is more complex has it includes cartilage. “It’s an extremely desperate and vast market with a limited solution,” says Meretzki.”
The CEO of this company would like to get the tissue combination to be functional though. If he does manage to accomplish that, he will have touched closer to the holy grail of what I have been proposing for the last 2 years. Even then, he would still need to account for the reserve zone of MSCs and the perfect growth stimulation factor combo.
To listen to a talk by the CEO, refer to this vimeo – https://vimeo.com/64006097