Crispr is an exciting technology because of the DIY possibilities facilitated by website like The ODIN.  as far as I know there have been no instances of genetic doping.  Crispr on live adult humans is in exact.  You can only edit one gene at a time and the number of cells that are actually edited may be low.  There are still a number of potential targets:

1) general anabolic target like HGH,IGF1,IGF2.  This would make it easier to see gains in slow height increase.  Some bones like the jaw do have potential to grow naturally in adulthood.  As seen in people with acromegaly.  An anabolic target would allow us to see a height increase method that may take a year to yield results get results in a much shorter time frame.  Something like HGH also increases bone turnover since cortical bone may impede height increase this would be useful for height seekers.

2)  inject specifically in the articular cartilage.  since these cells are an isolated population pretty much this is a possible target.  Even if crispr only alters one cell if it results in massive ECM production that could lead to height increase due to ECM…you could also increase chondrocyte proliferation…  this would have to be tested on animal models first as you would want to know what kind of effects this is going to have… If your knee is overproducing ECM that could result in loss of knee function. if you have open growth plates injecting there is a possibility too but again we’d want to know what happens in animal models first as you could really mess up your growth plate.

3)  target the osteoclasts.  You could weaken the bone enough to allow growth.  Cortical bone inhibits bone from growing interstitially(from within) so if you degrade it you could allow for bone to now grow interstitially.  But this could really mess up your bone and Hgh already increases bone turnover.  .  And it would be hard to inject into the bone itself.

4) weaken ligaments and periosteum which may constrain growth again would have to be tested on animals first as you would have the potential to mess up your body.

5) target the marrow cavity.  You could potentially induce differentiation of stem cells within the marrow cavity.  This could create neo-growth plates.  It would be exceptionally hard to do this as a lot depends on the microenvironment of the cell.

There’s not a lot of potential for self test for CRISPR.  At most you could target one gene in contrast to a mechanical method which can alter many genes.  The best bet is a general anabolic as making a bone length increase faster would be a huge aid in testing.  However, there are likely already people trying to do this and I haven’t seen amazing results with myostatin(which does help for bone too).

The best bet for DIY CRISPR testing is on animals.  Experiments would have to be designed carefully to not go over budget.  Ideally though a ton of genes and methods would be targeted to see what sticks.

Here’s a paper on musculoskeletal applications of CRISPR technology.

” mouse RAW264 cells deleted for Zscan10 and differentiated into osteoclasts by RANKL”

“With orthopaedic tissues, the extracellular matrix also presents a significant barrier to deliverystimulation were found to have increased osteoclast activity.”

”