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Increase Height And Grow Taller Through Bioprinting And Electrospinning

A big idea that is going around regenerative medicine circles now with the 3-D Printers that have been coming out is the idea of printing one’s own organs and body parts for use in transplantation.

The idea of bioprinting and electrospinning has been getting bigger and bigger in the last 2 years. What I am proposing in the year 2013 is that one day within the next 30 years we will be able to take a small cartilage or pluripotent stem cell sample from a person and be able to completely create a good sized growth plate completely regenerated for a person ready to be implanted.

This would result in people being able to choose to regrow again making them taller and taller.

When I typed in the phrase “Bioprinting” into Google the first result they gave me was of a company named Organovo, which has a tagline of “CHANGING THE SHAPE OF MEDICAL RESEARCH AND PRACTICE”. From their front page…

Organovo creates living, three-dimensional human tissue models for research and therapeutic applications

The flexibility of our bioprinting technology, which marries biology and engineering, and its proven application across a wide variety of cells, allows us to target many different tissues for development of human tissue models.

We are currently building a number of 3D tissue models for research and drug discovery applications, and well as working to fulfill our vision of building human tissues for surgical therapy and transplantation.

Under the Therapeutic Tissues section…

3D Human Therapeutic Tissues – At Organovo, we believe that engineered tissues will someday be a routine source of therapy for patients with damaged or diseased tissue.

Changing the Shape of Medical Practice – Organovo is working to fulfill the vision of building human tissues for advanced surgical therapy and transplantation.

Today, we are working, both internally and with select partners, to fulfill our vision of building human tissues for surgical therapy and transplantation. The flexibility of our tissue engineering technology, and its proven application across a wide variety of cells, allows us to target many different tissues. The cell source can be either allogenic or autologous (using the patient’s own cells), which could allow us to avoid transplant rejection and the need for life-long immunosuppresant drugs.

Significant science and discovery is required to develop a tissue therapy, ensure safety and efficacy through controlled clinical trials, and gain regulatory clearance as a medical device. Supplemental tissue therapies that could come in forms of tubes, patches, or organoids are a developmental possibility today. Larger replacement tissues remains a future goal; however, the insight gained through the development of supplemental tissue therapies can serve as key guideposts for the ultimate development of functional organ replacements.

The promise for tissue therapies that cure disease, with reduced risk of immune rejection, made on demand from cellular building blocks rather than waiting for a limited supply of donor tissues, is a vision we are passionate in pursuing.

I showed in a recent post that university researchers have been able to grow a growing bone with it’s epiphyseal growth plate cartilage being completely functional. This shows that by combining the fields of stem cell therapy and tissue engineering, the growth plate can be regrown using the initial stem cells, an external growth factor stimuli, and a scaffold to hold the two main parts in place ready for implantation. This company Organovo has the potential to make a real big change in the way physicians and surgeons have been practicing medicine.

Just like how the inventor Eli Whitney managed to create the idea of Interchangeable parts for machines and guns leading to the revolution of factories, specialization, systems, automation, and mass production of everything becoming one of the main causes of the Industrial Revolution, this new technology of being able to print in 3-D the tissue and organs we will need means that maybe one day humans will be looked as less as a single entitle but as a combination of organ systems which can be kept alive by just replacing the parts that go bad, old, or not working.

From the section on Bioprinted Human Tissue

Organovo’s proprietary bioprinting platform captures the unique synergistic potential of engineering and biology to enable the reproducible, automated creation of living human tissues that mimic the form and function of native tissues in the body. Our 3D bioprinted human tissues are constructed with precision from tiny building blocks made of living human cells, using a processthat translates tissue-specific geometries and cellular components into 3D designs that can be executed by an Organovo NovoGen Bioprinter™. Once built, the bioprinted tissues share many key features with native tissue, including tissue-like cellular density, presence of multiple cell types, and the development of key architectural and functional features associated with the target native tissue.

Organovo’s 3D human tissues offer many advantages over standard cell-culture platforms due to the fact that three-dimensionality is achieved without dependence on biomaterial or scaffold components that would not be found in native tissues.

We are not immortals and we are not superheros like Superman and Wolverine. Gods have bodies that don’t age or get ill. Superman has the power to be invulnerable against everything except Kyptonite. Wolverine can be hurt and injured but his body has insane cells which can heal any wound within minutes, if not seconds. Maybe one day we can develop soem type of technology, where all we have to do is take a gun with some medical light and shine it on a part of our body to solve all medical problems. Before that can come to be, the next best thing is the idea of having the ability to grow our own body parts, for fast surgery transplantations? Need a new liver, kidney, or pancreas? Let’s grow that for you in the lab?

For our situation, we don’t have any more growth plates so what do we do? We extract a little bit of cartilage and chondrocytes, and grow them into adult sized growth plate cartilages and transplant them into the leg. That means that we can start the longitudinal growth of the bones again.

Here is a video below of one of the founders of the company Gabor Forgacs who is giving a TEDTalk about his company’s technology.

For a better read on the subject of bioprinting refer to the article from a website called Explaining The Future

I would also like to the refer the reader who is mainly interested in using this technology for the cosmetic reason of potentially increasing their height this picture I found from another source/ article talking about the exploding, new hot biomedical field of 3-D Bioprinting research. Refer to the picture below. Notice that the picture on the researchers from Wake Forest University shows that they have been able to recreate the outer ear. That is cartilage. This shows that scientists have already been able to create cartilage nearly from scratch by using the bioprinting machines.

Screen Shot 2013-06-08 at 7.52.38 PM

Using Acids To Induce Reverse Ossification For Calcium Mineral Absorption

A little well known idea that I did not know about is from a grade school science project may give a proposed idea on how to reverse the bone ossification process to make the bones much more flexible and elastic for tensile loading leading to plastic deformation.

It involves the idea that if you take normal dried up bone (like from a cadaver) and put it into a vinegar solution the bones will actually eventually become like a hard rubber material.

Implications For Height Increase:

I think at this point in the research it is critical that we figure out some way to make the bones easier to bend and stretch. The idea of soaking bones in acid to de-calcify them is a very interesting proposal for bone lengthening later.

From source #2, it seems that vinegar like most acids can dissolve the calcium crystals from insoluble into soluble. The chemical reaction that is shown is….

CaCO3 + 2CH3COO -> Ca(CH3COO)2 + H2O +CO2

From Source #2: Once paired with vinegar, the calcium takes on the form of calcium acetate, which is soluble, so the calcium is absorbed and able to be utilized by bone.

A second, lesser known reason, is that the main acid in vinegar, acetic acid, lowers the amount of phosphorus the body can absorb. Phosphorus is a strong acid from meats and beans and grains unlike the weak acid of vinegar. Normally a certain amount of calcium will cleave to a certain amount of phosphorus and they will cancel each other out. When vinegar gets involved, less calcium is needed to cancel out a greater proportion of phosphorus and therefore less phosphorus is absorbed. If too much phosphorus came through, calcium would have been taken from bone to neutralize it….This is one of the reasons a children’s bones grow so rapidly. Children have a high ratio of good bacteria in their colon that synthesize acetic, as well as lactic, and other acids from the fiber or lactose that is eaten. As we grow older we don’t eat the right foods to support these guys. On a side note, that is one of the reasons Honey is good for bones as well. It specifically feeds these guys and keeps them cranking out acetic acid….Finally, while an acid, vinegar is like fruit in that the end product is not an acid at all. Once all of these reactions take place, the end products as you can see above are water and CO2. We breath out the CO2 into the air and end up with a net positive of base.

Analysis: I don’t remember my organic chemistry studies that well but I will take a crack at the logic behind the answer given by this guy.

First, he made a mistake on the 2nd compound, which is supposed to be ascetic acid. All acids have a O-O-H ending, so the right answer to balance both sides of the chemical reaction accounting for each element is to change the CH3OO into CH3OOH.

2nd, the guy is saying that the ascetic acid will lower the amount of phosphorous the body will absorb. However we know that the calcium is combining with the phosphorous in the human’s body to make the calcium phosphate minerals. I also assume that when the speaker is talking about the body, they are talking about the blood stream. If the ascetic acid is indeed somehow lowering the amount of phosphate the body is absorbing, then there would be more phosphorous being pushed out of the blood stream, and ending up in the bone matrix. If this is happening, then I would say that the bones would actually be getting stronger. More phosphorous, meaning more calcium phosphates, which are the hydroxyapatite, means the bones should get stronger and tougher, not the other way around.

He is right that the calcium cleaves to a phosphorous, but they don’t actually cancel each other out. The calcium somehow binds to the phosphorous forming a stable hard mineral. If that is what the guys means by  “canceling each other out” then okay, that makes some sense.

The thing is that we do need phosphorous to make the bones hard. Maybe what the guy means is that the ascetic acid is keeping the phosphorous from binding to the calcium. If that is what the guy means, then that would make sense. the phosphorous can’t join together with the calcium to make the hard minerals, making the bones softer. However, all of this is assuming that when he is talking about phosphorous absorption, he is not referring to the blood which is what I assumed in the beginning, but actually by the calcium element.

From source #3: The acetic acid of the vinegar will dissolve the calcium carbonate in the bones.

Analysis: It is interesting that again the people who are answering the question about how vinegar can rubberize bones keep saying that it is calcium carbonate that is reacting with the ascetic acid. However I am guess that it is the calcium phosphates that are the real reagent here. Let’s remember what we learned about the real calcium minerals that make the bones hard. It is the hydroxyapatites, calcium phosphates. Source 3 is good in showing that there is actually two main components that give the bones their hardness…

1. the collagenous material that gives the bones high tensile strength and make them flexible.

2. the calcium based mineral crystals which are inorganic, non living that is embedded all throughout the bone extracellular matrix. The calcium minerals gives the bones an extremely high compressive strength.

  • So calcium carbonate is… Ca5(PO4)3(OH
  • and calcium phosphate is… Ca5(PO4)3(OH 

So my real question is what is the ascetic acid of the vinegar really reacting to? and also, what is really giving the bones their hardness and strength?

The people who are giving answers on how vinegar can de-ossify say that the CH3OOH is reacting with calcium carbonate, but I am guessing that the real calcium mineral the acid is reacting with is calcium phosphate. The calcium mineral is obviously being broken down/dissolved by the acid in some way.

In the end, we could just say that from elementary grade school science projects, the bones do indeed lose their hardness and strength becoming almost elastic. This is what is important.

We have a very cheap, read at hand way to possibly de-ossify the bones to a level of elasticity where stretching the bones becomes a possibility.

So is there something that I can propose right now like a easy to make device we can put around our leg bone to make them softer for stretching? I don’t have anything right now but it should not be that hard to create a device we can either stick, glue, or embed to the surface of a bone to make it weaker. The fact is that the upper/proximal epiphysis of our tibia is right by the skin.

A band with vinegar inside which we can insert through the skin to the bones will be easy thing to invent.

Does Being Lactose Intolerant Mean A Person Will Have Stunted Growth And End Up Shorter?

Something that I have noticed in my own life in meeting different types of people their own unique genetic predisposition and hereditary traits is that having certain types of genetic tendencies leading to allegies or intolerance towards some foods may have some type of correlation to stunted growth.

I would like to propose the theory in this post that people who have the food allergy of being lactose intolerant have at some level stunted growth and end up shorter than a person who can ingest lactose rather easily.

For me personally, I have a small level of lactose intolerance. I know that when I was younger I had digestive problems whenever I consumed large amounts of milk or milk derivative products. I would learn later that two people who were around my age being females seemed to have been allergic to milk and lactose as well from their fathers’ genetic makeup. They ended up being either average in height or shorter than average.

So the common layperson can make the easy correlation with

  • Being Lactose Intolerant
  • The main type of sugar found in milk of cows is lactose
  • Milk has besides the lactose sugar, Calcium and Vitamin D
  • If a child can not ingest milk because the sugar inside cow milk causes them problems, they would avoid milk and chess – This means that they probably are not getting as much Calcium and Vitamin D into their diet as another person who is not suffeirng lactose intolerance would.

In a very old post The Real Correlation Between Milk, Calcium, Bone Growth, And Height” I did state that the correlation between increased milk consumption and increased growth and final height is actually very weak. However that does not mean that they are not completely uncorrelated. I would write in a recent post “Drinking Milk And Getting Calcium Will Only Increase Growth Rate And Height Substantially In Pre-Pubescent Girls, A Personal Theory” a personal theory that for girls who have not reached puberty yet, the affect from increased consumption would have result in a reasonable increase in their final height.

The truth is that most studies done on children who are already in puberty and the teenage years show that increased calcium intake from taking supplements lead to only increased bone mineral density, but no increased bone longitudinal growth. However there are a couple of studies from the early 20th century when most nations still had a large percentage of their people not getting the necessary amount of nutrient that drinking milk did help increase the growth rate, at least for very young kids.

If the case is that milk can help very young kids grow taller, then the reverse logic of having an inability to ingest milk would result in decreased growth rates when the child is still very young leading to an eventual shorter final height.

For people with lactose intolerance, the consumption of milk with the sugar lactose would lead to stomach pains, stomach muscle cramps, development of gases, and flatulence. Since the associated pain and flatulence would result, the kid suffering from lactose intolerance would try to avoid drinking milk, eating cheese, or trying out dairy ice cream throughout their development. The decrease in Vitamin D consumption means that the ossification process in the growth plates will not be as fast in building the bones as when there is milk consumption leading to increased Vitamin D levels in the blood.

 

Half Of The World Is Hoping We Succeed And The Other Half Of The World Is Hoping We Fail

Sometimes I step back from the research and think about what the implications would be if we did succeed in the research. When I think about how maybe 2 decades ahead and we manage to pass through the scrutiny that would definitely develop after we start claiming that we have found a way or an alternative, as well as have researchers in some major universities test the proposed technique with consistent positive results, I am left wondering how the world would react to it.

I would view our research through the eyes of other people as something that can be described by the phrase….

“Half Of The World Is Hoping We Succeed And The Other Half Of The World Is Hoping We Fail”

We look at height as an anthropomorphic measurement of humans. Since height is a measurement of length, it is very easy to quantify and analyze. there will always be people who are below average in height and people who are taller than average.

[Note: I am assuming that the majority of people in the world would rather be taller than shorter.]

The things is that there will be some people who will definitely feel threatened by this technology. They are the group of people who is hoping that we ultimately fail. – Those people will obviously be the people who from having blessed genetics ended up tall. Being tall has been part of who they are, their identity for so long. They derive at least part of their self esteem in being “tall” and feeling good that they are “tall”. What happens when a technology comes out to take away from one of the main things they thought they can claim to be.

Height has been for most of human history something that is supposed to be unchangeable, immutable. It is something that was supposed to be define an individual for the rest of their lives once they become physically mature. You can’t change it. The tall people could always at the back of their mind realize that no matter how much they screw up in life, they would always be tall. Their large stature will automatically cause other humans to develop a visceral reaction of developing respect, admiration, and presence. That is a great psychological cushion to fall back on.

They can be slightly less motivated, smart, or talented to reach the same level of succes because they have the big body, people in society will continue to give them breaks and chances to succeed. Being bigger means people feel a stronger level of presence and power, resulting in better human inter-relational dynamics.

Then in the 1980s Ilizarov came along from the former USSR and showed orthopaedic surgeons how it is possible to lengthen bones. This caught the attention of thousands of people around the world who wanted to be taller. While the original aim of distraction osteogenesis was to help children lengthen their legs due to bone growth problems, people immediately saw the cosmetic surgery application of this. When the surgery was finally allowed in China, thousands of Chinese people flocked to the few surgeons and hospitals which did this to change themselves. This resulted in limb lengthening surgery being banned in 2006 in China.

Some people in the world don’t want this to come to pass. this would in some way take away from them something which they thought would never change. Humans are always comparing themselves to other people to judge how much better or worse off they are. What happens when a person who used to be considered tall finds out that shorter people are now using a new technology to make themselves taller? I would think that those people would feel threatened and want to use the technology as well or want to keep the technology from ever being created.

Then there will be people who feel extreme hope and excitement that this technology will arrive soon, at some point in their lifetime. They are secretly hoping that we succeed and rooting for us every step of the way – They would be following closely with the news, the updates, and the research waiting years maybe for when the technique becomes commercial available for the masses.

These people have felt the psychological distress over having a body which they are not satisfied with, and there is nothing that they have any control over. They’ve tried all the stretching and done a lot of yoga but gained less than 1 cm of extra height, and that was just temporarily. They stand next to a taller person in a crowed room or in the work place and immediately feel an uncomfortable feeling of anxiety and distress. They can’t seem to be able to let go of the idea that they are so much smaller than other people and there is nothing they can do for the rest of their life about this thing. Life would seem too unfair. Some people due to the genetic lottery had the genes to become tall. They didn’t get it.

At some level they know that no matter how much they achieve in their professional life, the amount of effort, work, and pain they have to go through will be more than the taller person. Humans as a species have almost universally looked to taller people as better.

If the technology is created the shorter half of the world will be extremely happy. They would want this thing immediately to change their bodies, to make them just as tall as the taller people, or even taller. When that time comes, we will see a radical change in human society.

When To Give Up On The Search To Grow Taller And Stop The Research

In the last few months, I have been getting more and more emails from people expressing to me their thanks for creating this amazing resource for all of their height increase and growing taller questions.

They find it refreshing that this website is honest and not trying to sell them something. One thing that some of them have said is that they are hoping that I, as well as other researchers, don’t ever stop in the search.

Well, that is what they want, but what about my decision? What if one day I want to stop doing the research an give up on the search and leave it to someone else?

For this post I wanted to talk about the idea of “When To Give Up On The Search To Grow Taller And Stop The Research”. I know very few people who can continue this level of intensity for this thing for so long. I can do this type of thing because I have the time, the background, and the insanity to try to figure this thing out.

When To Give Up On The Search To Grow Taller And Stop The Research

So when do most people stop trying to grow taller, and start focusing on other things and ideas in life, like say….

  • Making money
  • Finding a gf/bf
  • Starting and running a business
  • Taking a full course load in college
  • Working 2 full time jobs
  • Getting married
  • Trying to loss weight, instead of gain height

As people grow older, their priorities change. What they once valued as the most important thing in their lives, they now look at as only secondary in important.

Here are the real top two reasons why people move away from this endeavor…

Money/Job – They realize that they need to put much more focus and energy on their job, to save money up for a marraige, retirement, children’s savings, etc.

Getting Married/Having a Child – Once a person gets married or has a baby, the focus in their life will no longer be about their physical appearance, or trying to gain something for themselves. It will be towards on how to provide the emotional, financial, and physical support that either their spouse or children need. I don’t think I have found a single person who is married or has a child and still actively searches for a way to grow taller.

Life moves on for many people. We can’t continue to focus on this type of thing for so many years of our lives because we are not letting ourselves enjoy the limited time we already have. We miss out on the chances for fun, for happiness, and for love. Most of us would rather choose to go on a hot date with someone we are attracted to than spend an evening doing stretches and taking supplements.

It is time to really start enjoying your life and worry less about this issue. For almost all of us, we can’t change our height that much yet since the technology and science has not arrived yet.

Here is what I can promise to the readers now.

1. I promise you the reader that I will try to keep this website up as long as possible. – Even if I am no longer updating the website as much as before, I will still pay the yearly hosting fee to keep the website around and up for future visitors to find and do their own research.

2. I promise you the reader that I will be updating, editing, and making changes and additions to the website over time for at least the next 5 years. This is a project which I want to ultimately culminate with a very thick book on everything I have found in my research. That book can be used by future researchers to push the endeavor a littler further than me.

3. I promise you the reader that I will never lie, exaggerate, or hide anything in terms of the research that I & the other researchers are doing just so that we can make a quick dollar.

I believe in trust, and have worked hard to earn that trust from you.

4. I promise that the research and findings we get are based on scientific backings, articles, PubMed studies, etc. 

5. I promise that if (or when) we have maxed out everything that can be done by us Amateurs Researchers in the scientific research, then we will tell you. We will write a final message saying that we did everything we could, and searched everywhere (basically the entire internet space and all university medical school library textbooks) and we still could not find anything that would work.

6. I will admit that I was wrong, that we couldn’t do it, and that the idea of an alternative to limb lengthening surgery is not possible if we find nothing in the end. – I would be willing to admit failure, even after struggling through this thing for years, if not decades. Maybe this thing is not really possible, at least at this stage of human technology and development.

Conclusion

This thing that I and the other height increase researchers are doing, it is a worthy cause. At least I believe that this thing we are doing is a very worthy cause. Millions, if not billions of people around the world would love it, and probably secretly wish that we would succeed in finding that holy grail, that solution towards growing taller after the natural growing process stopped.

I can’t make any guarantees or promises. I will share what I find and tell the truth.

Some people might ask whether I am qualified to do this type of research. So what are my credentials?

I did a degree in Chemical Engineering (with honors) for my undergraduate education with an emphasize in Material Science and almost got a minor in Physics. I have done research in the fields of biomedical technologies, fuel cell technology, polymer chemistry, tissue engineering, designing computer algorithms, AIDS vaccine research, electrical resonance, and clean energy alternatives.

I honestly think that if there is anyone on earth who would have a shot at taking a crack at this problem and possibly finding a solution, it is probably me. If I can’t succeed, I would wish that I can at least make a few big breakthroughs and write a few big posts showing that researchers and scientists in the world are at least working on this problem, but at a snail’s pace

I am just saying that my commitment and dedication to this thing will stay. Once the research is finally done, then I will walk away since there is no more to do.

Review On The RGX Grow Taller System, Grow Bone System

As I was going through the usual Grow Taller Forums, someone linked to this website http://www.growtaller.co.nr/ which is selling another grow taller system, this one named the RGX Grow Taller System which is also called Grow Bone System.

This website seems to be new and the co.nr domain name is something i have not seen before. The co.nr is for some small island nation in the pacific ocean, Nauru, which I didn’t even know existed until now.

So the big question is obviously, is this just the next grow taller supplement scam to come up on the internet, another peddler of fake pills that can never work?

Grow Taller System

Analysis

There seems to be two products that make up the Grow Bone System, the RGX Grow Bone System with RAW Calcium and Growth Factor S.

You are supposed to grow 4-6 inches for every 3 months you take the pills.

If you click on the PayPal button for the 30 day supply of RGX Grow Bone Systen, it will charge your paypal account $100. I obviously didn’t buy it but I am suspicious of the fact of whether they would even send anything in the mail.

The website has almost no information except one page of information on the ingredients of the pills. For the ingredients I see nothing that would be considered remotely special. Like it says, there are 2 pill types being sold, one called RAW Calcium, and there is something called RGX Growth Factor S.

RAW Calcium is supposed to have the element of Calcium in powder form, which should be relatively harmless. There is Vitamin D3 which will help with Calcium absorption by the bones. Vitamin K2 has been shown to be helpful in possibly reversing cavities which are minor so it might have some osteogenic potential. The magnesium will just give the bones that takes them some extra strength.

RGX Growth Factor S is supposed to have strongtium, which is something that is found in trace amounts in bones. I don’t know anything about strontium and whether it can really help in the health of bones since I have never done any research on strontium.

These two compounds have elements which will makes bones stronger in terms of making bone mineral density increase, and make bones stronger. However, there is nothing in these pills that will make the bones grow longer. 

There is a picture of a guy who is standing up having his picture measured however I recognize that picture as Apotheosis of the Make Me Taller Forum who was featured on national television for ABC NEWs and showed how limb lengthening surgery increased his height first from 5′ 6 to 5′ 9″ and then a second surgery made him go from 5′ 9″ to 6′ 2″

Conclusion

The fact is that there is a picture of a guy who used limb lengthening surgery to grow taller on this website (Apotheosis of MMT) who is also promoting height increase but trying to sell their program which is only pill and supplement based. This shows that they are lying about the effectiveness of their program and system.

Why would these people selling this thing and use a picture of someone else using a different system or path towards height increase? Why don’t they use pictures of new people that tried their marketed program and grew taller? I suspect the reason is because they have not found anyone who has grown from taking the supplements they sell.

So is this website and the product they are selling just another internet grow taller scam? Yes.