Last time it looked as though my right finger which I loaded via LSJL was about 1/4″ longer.  Now it looks like it’s about .375″ inches longer.  I’ve been loading about every day for about a 100 count on each of the three joints of the finger.  I increase the load as fast as possible, I could do more but I worry about injury because the clamp is so much stronger than the finger.  I might work up to more.  Two joints I load side to side but since the hand is in the way for the knuckle I load from top to bottom.  Here’s a post regarding my previous results and some images about how I perform LSJL. Here’s an image of my fingers now: Now it’s an extremely significant increase in finger length that is a result of LSJL.  Now I do have some osteophytes and the finger growth is not the same as normal finger growth.  In some of the other images you can see some finger deformities relative to a normal finger.  But it’s still a strong proof of concept that LSJL works to lengthen long bones. I’d rather prove LSJL sooner rather than later.  Would x-rays help?  I don’t really want to get them if they won’t convince people because it would cost a couple hundred dollar.  A lot of people don’t know exactly what makes you taller.  They can’t connect that long bones make you taller and the finger bones are long bones.  If LSJL can increase the length of finger bones(which are long bones(although they do have some different properties to other long bones)) then LSJL can increase overall height if those long bones are legs. As far as my leg progress though, I find that I can’t get as intense a clamp on my knees as I can on my fingers.  I think part of the reason is that there’s a lot of tissue types you’re clamping when you clamp a synovial joint.  It may take a bit of time before these tissues adapt to the clamping force.  I’ve been clamping for a long time with the C-clamp but there was a lot of slippage so there’s now a lot more force with the Irwin Quick Grip that i’m used to.  So right now I’m clamping with the Irwin Quick Grip to about a count of 130 before the pain in the soft tissues is just too irritating but over time the soft tissues will adapt and I’ll be able to clamp with as much force as I want as I have with bones I’ve been clamping a long time. So I’d recommend not clamping past the point of too much soft tissue pain and just try to increase clamping duration and intensity over time to allow the soft tissues to adapt. Remember, that LSJL is untested so there are guarantees that you won’t get injured or other maladies. Of course, if we could just prove LSJL then more testing can be done.  The question is how can we do it now rather than having to perfect it to increase leg length first?

Michael: The finger seems to be definitely longer, but you said that you clamped in all three joints.

• Does that mean that the clamping was also at metacarpophalangeal joints?
• How did you do that, and how can we not make sure that the MSP Joint did not go into inflammation mode aka swelling?
• There is so much evidence that finger joints can swell up if you hit them on something.

X-Rays seem to be the way to go. We measure the synovial joints of the index finger of the right hand compared to the control of your left hand’s index, which I hoped was never clamped, and see whether the lengthen is from the tissue in the synovial joints thickening as a response. If there is a difference in the distance between the bones in either the PIP and/or MCP joints, then the lengthening was not bone. If the distance in the PIP & MCP joint locations are the same, then we then say that the lengthening was truly bone.

You don’t have to go in for a GP check-up. Look into Urgent Care Centers (Source: Which is Cheaper Out of Pocket: Urgent Care Facility or Hospital ER?). They usually accept Insurance. I’ll even put down $70 for the X-rays if that helps.

An Interview With Dr. Tarek El-Bialy On Using Ultrasound To Regenerate Tooth Dentin

A few days ago we got a comment by someone calling themselves Pete who linked to an interview given where the Canadian Dr. Tarek El-Bialy was being interviewed on his Ultrasound Device & technology to use to regrow teeth, but stimulating the root of the teeth.

Originally we had written about the technology in a very old post “Teeth Regrowth Using Low Intensity Pulsed Ultrasound, LIPUS“. The researcher we mentioned in that article was a Dr. Jie Chen, also in Canada who claimed that they could use Ultrasound to not just make bones heal fractures but make people grow taller, which was something that was edited into the Wikipedia article on LIPUS (Low Intensity Pulsed Ultrasound). Tyler really got into the idea of using LIPUS and really deep into LIPUS but I had written in the past year a few times showing multiple articles which disprove the idea that Ultrasound would ever lead to increased longitudinal growth in the long bones. Yes, LIPUS machines are already on sale at rather cheap prices, so if there was real evidence in articles and the scientific literature that shows the really small LIPUS devices does any even the slightest chance of increasing longitudinal growth, I would recommend the portable LIPUS devices on this website, since they are just around $30-$50 each, and may be even free if one has the right type of medical insurance.

In fact, I recently downloaded the PDF of an old article I had eluded to to reread the implications on what would happen if you continuously emit ultrasound in lab test rabbits growth plates. (Effect of continuous therapeutic ultrasound in rabbit growth plates).

However, the technology of LIPUS on nerve tissue and teeth regeneration is much more promising. As Dr. El-Bialy (Associate Professor of Orthodontics and Biomedical Engineering at the University of Alberta, Canada) seems to suggest, LIPUS can regenerate damaged nerves and root pulp.

You can download the MP3 of that interview wth Dr. El-Bialy Available Here

It may not be our primary focus, but learning about the science of teeth and regeneration of teeth might lead to less money we have to spend at the dentist office in the future.

This study doesn’t relate directly to height growth but it is by the scientists whose research was the foundation for LSJL.

In vitro and in silico analysis of an inhibitory mechanism of osteoclastogenesis by Salubrinal and Guanabenz

“Synthetic agents such as salubrinal and guanabenz, which attenuate stress to the endoplasmic reticulum, are reported to inhibit development of osteoclasts. However, the mechanism of their inhibitory action on osteoclasts is largely unknown. Using genome-wide expression profiles, we predicted key transcription factors that downregulated nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), a master transcription factor for osteoclastogenesis. Principal component analysis (PCA) predicted a list of transcription factors that were potentially responsible for reversing receptor activator of nuclear factor kappa-B ligand (RANKL)-driven stimulation of osteoclastogenesis. A partial silencing of NFATc1 allowed a selection of transcription factors that were likely to be located upstream of NFATc1. We validated the predicted transcription factors by focusing on two AP-1 transcription factors (c-Fos and JunB) using RAW264.7 pre-osteoclasts as well as primary bone marrow cells. As predicted, their mRNA and protein levels were elevated by RANKL, and the elevation was suppressed by salubrinal and guanabenz. A partial silencing of c-Fos or JunB by RNA interference decreased salubrinal- and guanabenz-driven reduction of NFATc1 as well as tartrate-resistant acid phosphatase (TRAP) mRNA. Collectively, a systems-biology approach allows the prediction of a RANKL-salubrinal/guanabenz-NFATc1 regulatory axis, and in vitro assays validate an involvement of AP-1 transcription factors in suppression of osteoclastogenesis.”

“Salubrinal and guanabenz are potent chemical agents for the inhibition of protein phosphatase 1 (PP1) that specifically de-phosphorylate eIF2α. Through upregulating the phosphorylated level of eIF2α and reducing translational efficiency of most proteins except for a limited set of proteins, such ATF4, these agents attenuate stress to the endoplasmic reticulum. Gene regulation by salubrinal and guanabenz, however, not only takes place at the level of translation but also at the level of transcription. In osteoclasts, it has been shown that administration of salubrinal and guanabenz suppresses receptor activator of nuclear factor kappa-B ligand (RANKL)-driven activation of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) ”

“A partial silencing of c-Fos and JunB decreased the mRNA and protein levels of NFATc1. Furthermore, there was a feedback loop in which a decrease in c-Fos by salubrinal reduced NFATc1 expression, and the reduction in NFATc1 further attenuated the level of c-Fos protein. AP-1 proteins are known to play a critical role in osteoclast differentiation. It is reported that mice lacking c-Fos are osteopetrotic due to abnormal development of osteoclasts”

Unfortunately, no real LSJL insights in this study.

Update #16 – More Resources – August 1st, 2014

Last month I could not write up a post for updates and the reason was because the website was down for more than a week. There was some technical and legal issues which needed to be resolved. Here are some things that has occurred in the last 2 months

• We’ve established that Dr. Ballock at the Cleveland Clinic has been working on a project to study on how to grow a fully functional growth plates with a colleague, a Dr. Eben Alsberg, who I have previously spoke very highly of. The project is supposed to be finished in a couple of months so there is going to be some big news that will be coming out soon.
• I’ve established that in Google Patents there are multiple types of patents which show that researchers have been working on the science of remodeling bones, using different chemicals.
• Regenexx and Mesoblasts have both been trying to win over in the spinal disc regeneration niche of biotechnology but their amazing lab animal study results might not be able to be translated to humans. This is the first real example that what we find in the lab may not work in real life.
• I have reported on the news of Alexander Teyplashin’s team and shown that they are dead serious on putting neoepiphyseal cartilage into human bones to let them grow again. This was the most shocking news to come out and it did lead to some talk in the small community.
• Teplayshin’s team filed multiple patents and papers showing how to start from human adipose tissue, get stem cells from them, turn them into chondrocytes, and deposit into scaffolds. They figured out the vascularization problem.
• It seems that many of the people I have mentioned have been working in collaboration for quite a while and I wasn’t aware of it until now. For example, Dr. Jean Welter of the Case Western Reserve University, which is based in Cleveland has collaborated/worked with Dr. Ballock, as well as Dr. Eben Alsberg. It shows that like almost any other micro-niche industry and field, all of the people doing their thing seems to know everyone else that is working on similar projects. I will be talking much more about Dr. Welter’s research soon though.
• I have purchased multiple books in the last two months looking deeper into the anatomy and physiology on how joints function. They include the following “Joint Structure & Function, A Comprehensive Analysis – 4th Edition” by Pamela K. Levangie and Cynthia C. Norkin, “Treatment by Manipulation” by AG Timbrell Fisher, and “The Complete Illustrated Book of Yoga” by Swami Vishnudevananda. Some purchases have been to help me and others around me to develop a much more active and healthier lifestyle.

As for myself, I have been going to an acupuncturist (who was trained in Russia with a Ph.D and M.D) so have gotten myself much more interested in some of the more quasi-scientific/alternative approaches to medicine and healing. In the last  month or so I have looked into some very strange forms of bone and joint treatment.

As for the backend of the website, I changed the ownership of multiple part. I stopped making any type of adsense earnings on the website – I changed all the adsense ID #s to be under Tyler’s name. There is going to be some big things that I planning on releasing in the coming half of this year.