Me: This post shows that the effects of HGH and IGF-1 are actually different for different areas in the body. I showed in a recent post that the inject of IGF-2 in a localized region of the long bone (distal femoral epiphysis) lead to the long bone (femur) to lengthen. We know that from growth plate analysis that the growth plates have receptors for both GH and IGF-2, but from my personal research, the IGF-2 might have a more regional localized effect leading to increased limb length then torso/body length. However this study was done for IGF-1, bot IGF-2.
Analysis & Interpretation of study: It is important to realized that the upper/lower body segment interpretation means the lower body is the leg/limbs while the upper body is the torso. So a higher U/L value means there was more lengthening effect on the torso than the limbs. A lower U/L value means there was more lengthening on the limbs then the torso. It seems that with kids who have some form of growth hormone deficiency (isolated and multiple pituitary hormone deficiency) the limbs were the primary area of lengthening from using the hGH injections. However with kids who suffered from Laron’s Syndrome, intrauterine growth retardation, or idiopathic short stature the treatment with either IGF-1 or hGH did not change the U/L but did result in increase height so it seems that with these types of disorders, the distributed effect by the GH or IGF-1 was even throughout the body.
Differential effects of hGH and IGF-I on body proportions.
Laron Z, Silbergeld A, Kauli R.
Source
Endocrinology and Diabetes Research Unit, Schneider Children’s Hospital, WHO Collaborating Center for Diabetes in Youth Petah Tikva and Sackler School of Medicine, Tel Aviv, Israel. laronz@clalit.org.il
Abstract
The differential growth effects of hGH and IGF-I on the upper/lower (U/L) body segment in relation to height (Ht) were analyzed in 15 patients with isolated Growth hormone deficiency (IGHD,:7M, 8F) mean age 5.0 +/- 3.2 (SD) years treated with hGH; 21 patients with multiple pituitary hormone deficiency including growth hormone (MPHD: 14M, 7F) aged 10.0 +/- 3.8, treated with hGH; 9 patients with Laron Syndrome (LS) (4M,5F) aged 6.9 +/- 5.6 years treated with IGF-I; 9 boys with intrauterine growth retardation (IUGR) aged 6.3 +/- 1.25 years treated by hGH; and 22 boys with idiopathic short stature (ISS) aged 8.0 +/- 1.55 years treated by hGH. The dose of hGH was 33 microg/kg/day, that of IGF-I 180-200 microg/kg/day. RESULTS: the U/L body segment ratio in IGHD patients decreased from 2.3 +/- 0.7 to 1.1 +/- 0.7 (p <0.001), and the Ht SDS increased from -4.9 +/- 1.3 to 2.3 +/- 1 (p < 0.001) following treatment. In MPHD patients the U/L body segment decreased from 1.1 +/- 1.1 to -0.6 +/- 1.0 (p < 0.001), and the Ht SDS increased from -3.3 +/- 1.4 to -2.5 +/- 1.0 (p < 0.009). In the LS group the U/L body segment ratio did not change with IGF-I treatment but Ht improved from -6.1 +/- 1.3 to -4.6 +/- 1.2 (p < 0.001), The differential growth response of the children with IUGR and with ISS resembled that of the children with LS. CONCLUSIONS: hGH and IGF-I act differentially on the spine and limbs.
Note: This post will be one of those that will be continuously edited and added upon as the site goes on
To enhance your life, life quality, and life expectancy, these are very nice resource websites or forum boards you can checkout which I have found throughout the internet space. They deal with nutrition, supplements, and
To enhance your mind, cognitive ability, mental fitness, memory, intelligence, power of focus and concentration, and everything else related, these are the resource that I have found which I think are rather informative and good.
Me: For Mind Hack XV, I found this amazing interview a past memory champion Joshua Foer did on his journey and process to learn the ways and techniques to make one’s mind better at memorization and thinking. I highly recommend the interview since it is very insightful. If you don’t have the time to watch the video, I will outline the major points they bring up in the video.
You can train yourself to do unbelievable feats.The memory champions in memory competition are using their brains differently so you can learn what they are doing..
In Ancient times like in Greece, there were many well known memory techniques and tools for the scholar. We have totally forgotten about these techniques.
Major Technique #1: Creating a memory palace – Most people have terrific spatial memory. If we can use that spatial memory to remember stuff that we actually want to remember, it gives you an extraordinary advantage. The memory palace is an imaginary building in your mind’s eye that you are intimately familiar with. You walk through it in your imagination creating images of the stuff that you wish to remember.
By putting imagery in a specific location in the memory palace, you are attaching it in an order, in a spatial arrangement,
Idea: If you can create images that are so weird, so bizzarre, so strange, gory, raunchy, etc. something that is so emotionally resonant, where you use all of your senses to embrace the image, that will be a memory you will not be able to shake away from your memory.
Interesting fact #1: The term “In the first place” actually is referring to the “First Place” in your memory palace.
Interesting fact #2: The word “Topic” comes from the Greek word “Topos” which means “place”.
Idea: The things that we remember are the things that are …
1. NEW,
2. STRANGE,
3. UNUSUAL,
4. THINGS THAT MAKE AN IMPRESSION ON US,
5. THINGS THAT GRAB OUR ATTENTION
We can will our brains to remember.
Idea: We can change our brain through memory. Remembering a lot like cab drivers enlarges the hippocampus which is what controls spatial memory.
Our working memory capacity has a clear limit. We can only hold roughly 7 things in our head at one time. The idea and key is then to see how we can package and put as much stuff in those 7 parts as possible.
Chunking – The process of packaging large sets of data and information into smaller parts to make it easier to recall.
Baker-Baker Paradox (from psychology): A person who is asked to remember a guy’s name is Baker is less likely to remember than a guy who is asked to remember that a guy’s profession is a baker.
The name “Baker” does not mean anything. It is not associated or attached to anything in our memory as a hook. The word Baker however does have something we can associate with. There is a whole network of meaning that the word “baker” is attached with it.
The entire trick to remembering other people’s names is to take their names, turn it into something that they can associate with, in a visual way that would give it more meaning.
Most of the memory techniques uses a concept from psychology called elaborative encoding – You take information and make it memorable by embedding it in other information we already know.
William James – “We structure our experience of time around chronological landmarks” – Exciting things that happen in our life helps shape the passage of time. As we grow older, our lives get less interesting. We are doing less new stuff everyday. Things start to become routine. They become rote….And as a result, time starts to feel like it is flying by….So, literally our life is becoming less memorable.”
Solution: To live a life that is memorable. To do things that are new, different, exotic.
Case with EP (patient): Struck with viral disease that ate away a significant part of his brain, the hippocampus. Lead to him being fully functional except not remembering short term memory and long term memory up to a certain point. Does not even realize that he even has a memory problem. Is content and happy because he can’t remember the past and does not worry about the future.
Memory is very costly due to energy consumption: Brain uses up to around 20% of all the Oxygen and 25% of the glucose that is available in the body. We need memory to shape our perceptions of the present, our ability to make sense of the present, to plan for the future.
Our identity can be defined as our memories. EP could be considered to be an empty vessel and incapable of telling you anything about time.
Thinking is not so much about remembering, but actually about forgetting – processing what things do they not need to remember.
Even at elite memorizing level, everyone has a weakness. Conversely, almost everyone has a great memory for something. Thus, the things that we are fascinated with and become experts in, we develop an extraordinary memory for the details of that field of study.
With great expertise comes memory. People are structuring memory differently. Theya re seeing the world differently. and as a result are remembering better.
True knewledge is having an understanding of the world, make sense of it, find meaning in its structure.
We are probably all better off not having to remember numbers and facts which we can find easily through books and google.
The Latin word inventio is the source or root word for two modern words, invention and inventory.
We should be teaching kids better how their memories work. If you teach kids how to think about thinking, they think better. The principles behind the memory devices and techniques like the memry palace are crucial in helping us do well in the world.
The best way to learn something is to space out the information over time. When we start learning, we will start forgetting.
The single best piece of advice for a person who just wants to improve their memory: The art of remembering is the art of paying attention. To be mindful..
The difference between natural memory and artificial memory – natural memory is what we are born with in terms of raw talent, artificial memory is what we can develop through learning and using structuring for information processing.
Grit and tenaciousness is very good at creating success
The YouTube link where the source is found is HERE
Me: This is one of those posts which I felt was extremely insightful in its wisdom on how the modern male in Western developed countries should be living his life. As always, this type of advice should never be used as gospel and not questioned but to be critically reviewed for its practically, usefulness, and value.
The reason why I felt this video is so powerful is because it tells us young men still in our 20s how to avoid some of the biggest traps which can sap away our resources. In our 20s, whether we have been to college or graduate school, most men are very busy at trying to achieve, win, and climb the corporate ladder in making a name for themselves in the world. We have the energy, ambition, and motivation to try to, as Steve Jobs put it, “put a dent in the universe”. Whether we ultimate succeed in whatever endeavor we have set for ourselves, that is still need to be proven. However there are some clear decisions we make which will make us far less likely to succeed.
On a side note, I would like to state that in many polls done on people in their 40s, they would say that the #1 decision which will determine the quality of their later years, whether it is in the area of health, finances, or relationships is the person they choose to marry, is they ever do get married ever at all. One’s decision on who will be one’s life partner is far greater in determining one’s happiness and success in life than almost anything else. We find from many reports that divorce is not just an emotional and mental negative event, but also for one’s finances too. So besides the tips that Tim will tell you, I wanted to give 4 tipes of my own.
Tip #1: Be extremely careful on who you choose to spend your life with. Your emotional health and financial health will depend on it later on.
Tip #2: It is important to realize that the two most common causes for personal bankruptcy is a major health issue racking up healthcare costs or divorce.
Tip #3: Having a child is extremely expensive, and be wise about having children.
Tip #4: Things become harder to do as one gets older so go ahead in your younger years, go crazy and have fun, and try to reach for one’s dreams. If you want to do something, do it now. You will definitely regret on doing trying it out later in life if you don’t try and go for what you want.
Me: I have recently found out from the website and publication Life-Enhancement about this really powerful supplement product called Galantamine and the articles and information about it is enormous. In my most recent post in Mind Hack XI I showed that IGF-2 dosage can increase memory ability but it seems that the pathway of IGF-2 is actually controlled by Galantamine. I had posted an article from the Nov. 2012 edition of LIfe-Enhancement. If you actually go through the entire LIfe-Enhancement website you will find that there are a lot of articles written about the power of Galantamine.
Seriously, the entire Life-Enhancement website is FILLED with Galantamine articles and how it improves some form of mental/cognitive ability. From the research on the internet on the effectiveness and ability of galantine supplements, it seems that one of the effects of Galantamine is that gives you more vivid and even lucid dreams. It seems that quite a few studies have been tested on the ability of Galantamine to treat and reduce the effects of Alzheimer’s Disease.
