Why Guanyl Cyclase And Natriuretic Peptides Are Important For Height Increase

I had previously wrote about the invention using Guanyl Cyclase through a vector injection in gene therapy to increase in height apparently twice HERE and HERE. Tyler in a post on June 18 this year wrote about the exact same thing HERE. That was more than a month before I started on this website.

It is quite clear that we have been scouring through the internet to try to find everything under the sun to push this endeavor and search for a possible noninvasive way to increase the height of people who have already reach physical maturity. So far I would say that we are doing a rather good job and at this rate, we probably could cover everything that is on the internet. One day we will have to regularly contact real doctors, specialists, and surgeons to be able to get answers.

So the question I wanted to answer in this post is why is guanyl cyclase and natriuretic peptides important for possible height increase and growing taller. I’ll just assume that you know the basics of the growth process with knowledge on the hormones and growth plate function.

You have these peptides known as natriuretic peptides which are ligands. There is 3 types in a specific family. You have the ANP aka atrial natriuretic peptide , the brain natriuretic peptide aka BNP, and the C-type natriuretic peptide aka CNP. The effect of the types of natriuretic peptides of ANP and CNP which are ligands for the receptors GC-A and GC-B. When the 3 types of ligands were tested on a culture of mice tibias simulating the longitudinal growth process in bones. It showed that CNP produced more cGMP than ANP which resulted in longer bones. closer look at the cells showed an increase in the height of the proliferative and hypertropic layers in the mouse tibias with CNP.   To mimic the binding of the CNP and GC-B, the experimenters used similar compounds. The conclusion of the study showed that the CNP/GC-B pathway is very significant in the endochondral ossification process.

Let’s look at this specific article found from PubMed. Source Link HERE.


J Biol Chem. 1998 May 8;273(19):11695-700.

Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide/guanylyl cyclase-B pathway.

Yasoda A, Ogawa Y, Suda M, Tamura N, Mori K, Sakuma Y, Chusho H, Shiota K, Tanaka K, Nakao K.

Source

Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606, Japan.

Abstract

The natriuretic peptide family consists of three structurally related endogenous ligands: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The biological actions of natriuretic peptides are thought to be mediated through the activation of two guanylyl cyclase (GC)-coupled receptor subtypes (GC-A and GC-B). In this study, we examined the effects of ANP and CNP, which are endogenous ligands for GC-A and GC-B, respectively, on bone growth using an organ culture of fetal mouse tibias, an in vitro model of endochondral ossification. CNP increased the cGMP production much more potently than ANP, thereby resulting in an increase in the total longitudinal bone length. Histological examination revealed an increase in the height of the proliferative and hypertrophic chondrocyte zones in fetal mouse tibias treated with CNP. The natriuretic peptide stimulation of bone growth, which was mimicked by 8-bromo-cGMP, was inhibited by HS-142-1, a non-peptide GC-coupled natriuretic peptide receptor antagonist. The spontaneous increase in the total longitudinal bone growth and cGMP production was also inhibited significantly by HS-142-1. CNP mRNA was expressed abundantly in fetal mouse tibias, where no significant amounts of ANP and BNP mRNAs were detected. A considerable amount of GC-B mRNA was present in fetal mouse tibias. This study suggests the physiologic significance of the CNP/GC-B pathway in the process of endochondral ossification.

PMID: 9565590           [PubMed – indexed for MEDLINE] 

 

5 thoughts on “Why Guanyl Cyclase And Natriuretic Peptides Are Important For Height Increase

  1. Jimmy

    So what’s the best way to go about increasing CNP? I know Alkoclar was primarily interested in this type of height increase but I don’t think he got anywhere with it.

    Reply
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