“During adolescence, sex hormones play an important role in regulating proliferation, differentiation, maturation, and the scheduled death of chondrocytes.
In the present study, we used adipose-derived stem cells (ADSCs) to differentiate into cartilage. Differentiated cartilage cells were used in the control (without estrogen E2 in the culture medium) and experimental (with estrogen in the culture medium) groups to evaluate the expression of type II collagen and aggrecan as chondrogenic genes markers.
Estrogen leads to inhibition of type II collagen gene expression and reduction of aggrecan gene expression.
Estrogen probably has negative effects on chondrogenesis process of ADSCs”
“17-β estradiol (E2) increased the type X collagen, inhibited the type II collagen, and reduced the proteoglycan content of the cartilage”
