Proposed Changes On How We Should Be Taking the Glucosamine Sulphate

After my recent trials with taking phenylpiracetam (a derivative of piracetam, which Amazon no longer sell) in my nootropic stack (which includes Omega-3, MK-7 (aka Vitamin K2), Bulletproof Coffee, and Modafinil), I firmly believe that it would probably be a much better idea to be taking all supplements sublingually than through the normal path of swallowing it through the mouth aka ingestion.

Multiple people have stated the side effects of taking Glucosamine Sulphate, liver problems, which I was aware of from the beginning. The Liver, like the kidney, is one of our vital organs, which is a filtration unit. It is used to remove the poisons and unhealthy compounds out of our body. If the liver develops a problem, we can die from it. Alcoholics are well known for developing liver failure after decades of high levels of drinking. In fact, the way college students die from high levels of binge drinking is because liver failure. The thing is that the Liver is part of the digestive system. Almost everything that we swallow will eventually get checked by the Liver to see whether it has any types of poisons.

This is the first big reason why we should chance the way we are taking it. If we can get the compound to the blood stream through a short cut, without it having to go through the digestive system or the liver, which can be damaged through overdose, then we can increase the dosage to a higher and still be relatively okay. 

In addition, our stomachs contain hydrochloric acid with a PH of 1-2 (very strong acid), and a thousands of types of bacteria. The acid and the bacteria have the job of breaking down all the solid foods we ingest. They act almost like a million small teeth, dissolve the hard solid and leaching out the good, useful vitamins and minerals.  (Refer to the Wikipedia article on Gastric Acid). We have a mucuos type of ooze which covers our stomach lining which protects the HCL from dissolving through the stomach membranes. When we feel something like acid reflux, or indigestion, the mucuous of the stomach lining has thinned out, and the strong acid is finally touching the stomach lining.

This means that any pills you swallow is going to have to go through a maze and a battlefield before they ever get to the cartilage or the IVD (intervertebral discs). No matter how well you cover the real active ingredient in a biodegradable polymer material when making the pills, and no matter what type of release mechanics is shown for the polymer cover when we are doing drug release studies (Refer to an example of the pharmaceutical article on how drug release studies on bio-absorbable coating polymer pellets over active compounds), I would guess that 90-95% of all the glucosamine will never reach the articular cartilage or the nucleus pulposus. The trick is to get it to the blood stream as directly as possible

Here is what I am suggesting

If you plan to take any supplements, crush it using a mortar and pestle, or grind it using a coffee grinder, Or mash it with a spoon into fine crumb-like parts. Just break it into small enough pieces which will allow the solid to dissolve easily through a thin layer of epithelial tissue membrane. I suggest again, get the compound grinded into powder or crystal form.

When you have have the pills in that form, put it under your tongue, sublingually. The compounds could be extremely bitter, (which is how the phenylpiracetam tasted like, and even made my tongue numb a few times. Could have been a bad batch. It didn’t work for me though) but it it would reach your blood stream faster, with higher percentage of the Glucosamine Sulphate intact.

Of course, the fastest way is to use a needle & syringe to inject the compound in some non-reactive, saline solution into an artery, but I am guessing few people are going to choose that option.

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A Side Note

There is a difference between the terms “poisonous” and “venomous”. WIth poison, you can’t ingested it or it will harm/kill you. Poison attacks you through the digestive system. With venom, it works by getting into your blood stream. If it gets into the blood stream, then it will harm you. Some venoms will not harm you if you swallow it.

That is why the Fer-De-Lance Snake, which is supposed to be the most venomous & dangerous snake in South America has a type of venom which you can swallow & ingest. If the venom gets to your blood, you are dead. However, if you ingest the venom to correct for protein deficiency, it won’t be as bad, but could even be slightly beneficial.

This particular side note is to show that the digestive, gastric, approach to take pills and supplements is very inefficient. Taking suppositories in through the anal-rectal and/or genital regions is often done as well (especially for older people who have difficulty swallowing or keeping any type of food down), as a way to let the chemicals get to the blood vessels faster, but few people would want that option.

So the benefits of taking the supplement this way are two-fold.

1. A much higher percentage of the main active ingredient actually manages to reach the blood stream and to the local active body area you are trying to target.
2. Since the compound are no longer going to be going through the digestive system, you can increase the dosage of the Glucosamine Sulphate to maybe even 3000 mg per day and will not suffer any type of liver damage.

I am not sure whether increasing the dosage would have increase effects, but this method of getting the supplement will let you increase the dosage to a higher level, than what is normally recommended by any doctor. The only down-side is the taste. Most pills are bitter.

If the primary physiological mechanism or pathway on how a compound is used requires it to go through the blood stream extensively, then it would be much better to just take it sublingually. Crush it, and put it under your tongue.

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