How To Accelerate Osteanagenesis And Revascularization Of Tissue Engineered Bone In Big Animals

This is a study that will help me to at least develop a better understanding on the type of ideas and surgical methods that might be needed to make bone healing be possible if any distractions made is too large.

Analysis & Interpretation

The paper is in Chinese so the translated version to English is not as clear for a native English reader to understand. The basic premise is that the researchers got a bunch of goats, put them in 3 groups, and drilled a 2 cm wide hole in the tibia of the goats. The holes are then added with three different types of materials for each of the 3 groups to see how well the material added will be in helping the natural bone heal. The three types of implants used are…

  1. Coral Hydroxyapatite (CHAP)
  2. Coral Hydroxyapatite & Bone Marrow Stroma Cells (BMSCs)
  3. Coral Hydroxyapatite & Bone Marrow Stroma Cells & fascia flap (whatever this is)

The results showed that the first two groups saw either no or little bone healing. The 3rd group showed that the bone defect at around 2 cm wide still maanged to heal almost completely.

Implications for Height Increase

This paper was unique because we are still looking at the best type of fast bone healing/osteogenesis material. There may come a point where we choose to go with the bone distraction idea and if that is done, the defects made could be dramatic and we would need to look for a tissue engineered mixture to heal large bone defects purposely induced. We see from this post that the compound fascia flap seems to have the ability to induce vascularization for bone healing.

From PubMed study The method of accelerating osteanagenesis and revascularization of tissue engineered bone in big animal in vivo


Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Feb;25(1):26-31.

[Article in Chinese]

Chen B, Pei GX, Wang K, Jin D, Wei KH, Ren GH.
Source

Department of Orthopaedics and Traumatology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. chb@fimmu.com

Abstract

OBJECTIVE:

To study whether tissue engineered bone can repair the large segment bone defect of large animal or not. To observe what character the fascia flap played during the osteanagenesis and revascularization process of tissue engineered bone.

METHODS:

9 Chinese goats were made 2 cm left tibia diaphyseal defect. The repairing effect of the defects was evaluated by ECT, X-ray and histology. 27 goats were divided into three groups: group of CHAP, the defect was filled with coral hydroxyapatite (CHAP); group of tissue engineered bone, the defect was filled with CHAP + bone marrow stroma cells (BMSc); group of fascia flap, the defect was filled with CHAP + BMSc + fascia flap. After finished culturing and inducing the BMSc, CHAP of group of tissue engineered bone and of fascia flap was combined with it. Making fascia flap, different materials as described above were then implanted separately into the defects. Radionuclide bone imaging was used to monitor the revascularization of the implants at 2, 4, 8 weeks after operation. X-ray examination, optical density index of X-ray film, V-G staining of tissue slice of the implants were used at 4, 8, 12 weeks after operation, and the biomechanical character of the specimens were tested at 12 weeks post operation.

RESULTS:

In the first study, the defect showed no bone regeneration phenomenon. 2 cm tibia defect was an ideal animal model. In the second study, group of CHAP manifested a little trace of bone regeneration, as to group of tissue engineered bone, the defect was almost repaired totally. In group of fascia flap, with the assistance of fascia flap which gave more chance to making implants to get more nutrient, the repair was quite complete.

CONCLUSIONS:

The model of 2 cm caprine tibia diaphyseal defect cannot be repaired by goat itself and can satisfy the tissue engineering’s demands. Tissue engineered bone had good ability to repair large segment tibia defect of goat. Fascia flap can accelerate the revascularization process of tissue engineered bone. And by this way, it augment the ability of tissue engineered bone to repair the large bone defect of goat.

PMID: 12905602     [PubMed – indexed for MEDLINE]

Using Chinese Traditional Medicine Bone Growth Fluid In Bone Lengthening Area

Me: The main reason for this post was to show that many of ancient traditional Chinese and Indian medicine which claim to promote and help increase height and grow taller may have some validity, although it is kind of hard to separate the real science from the exaggerations. We see this group of chinese orthopedic researchers in a military hospital in china try to inject and administer the “bone growth fluid” into goats to see what would be their effect on the healing process during distraction osteogenesis. The distraction is made on the upper metaphysis of the left tibia. The results seem to show that there was earlier bone formation was seen in the experimental group than the control group of goats. They conclude by stating “Chinese Traditional medicine, “Bone Growth Fluid”, could accelerate the accumulation of the trace elements in callus on the distracted sites and it might play some role in the promotion of osteogenesis and bone remodeling in bone lengthening.

From PubMed study link HERE


Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1998 Sep;12(5):315-8.

Experimental study on the effect of Chinese traditional medicine “bone growth fluid” in the change of trace elements in bone lengthening area

[Article in Chinese]
Zou P, Li Z, Ruan M.

Source

Orthopedic Center of PIA, Kunming General Hospital, Chengdu Military Region, P.R. China.

Abstract

In order to study the effect of Chinese traditional medicine, “Bone Growth Fluid”, on bone formation in bone lengthening, the limb lengthening model was made on goat to observe bone formation in the distracted area, and the content of the trace elements was determined. The bone-lengthening operation was carried out on the upper metaphysis of left tibia. The animals were divided into two groups following operation. From 2nd day after operation, “Bone Growth Fluid”, 10 ml per kilogram body weight, was given daily to goats in the experimental group, and same amount of normal saline was given to goats in another group as control. The results showed-that new bone formation and bone remodeling in the experimental group appeared earlier than that in the control group, and the content of the trace elements was also improved. So Chinese Traditional medicine, “Bone Growth Fluid”, could accelerate the accumulation of the trace elements in callus on the distracted sites and it might play some role in the promotion of osteogenesis and bone remodeling in bone lengthening.

PMID: 10437115       [PubMed – indexed for MEDLINE]

Reviewing Company LiftKits Or Lift Kits, Height Increasing Insoles By Derek White

Me: Although there is already quite a few links and online shops I put in the resource section, there does seem to be one company or corporation that I have noticed been getting quite a bit of media coverage, at least more than the usual shop which offers height enhancing footwear. I was recently made aware of a company called Lift Kits

The name of their website is My Lift Kits at myliftkits.com. Looking at the section and variety of products they sell, I would say that the quality and insoles they sell is above average than what you might find from Alibaba or Ebay. The founder is some guy named Derek White who seems to be based off of Hollywood, California.

It seems that there is even a few big named celebrities who is on video sponsoring this company and its products. In the video section HERE  the main video is from some actor Rick Mora (I don’t know who he is) who appears to be from the Twilight series movies, which I have no opinion about.

The message on the website says that with these comfortable insoles, you can increase you height by up to 2 inches. Judging by the insole thickness, I would say they are better quality and better suited for the wearer in mind than some other online shops. At least with these, they look kind of comfortable.

The big difference between the design of these insoles compared to others seems to be the ability to snap on more insoles in a easy fashion to add to the thickness of the insoles. It is kind of clever.

Ultimately it is about confidence and having a better state of mind. I think that is admirable. The website is fashionably designed, which can be easily made using a premium wordpress theme with the wordpress platform. The website is connected with social media to the biggest networks, and has a easy to reach phone number. From a internet marketing perspective, the website designer is doing everything right.

I personally don’t know much about the founder Derek White but I think he is an actor or at least someone in the hollywood scene. Lift Kits have so far been getting press from some of the biggest magazines around including Maxim, US Weekly, Elle, inTouch, The Today Show, The Tyra Show, OK! Magazine, and many many more. Overall, this Derek guy is not selling something completely new, but the marketing and personal connections the founder has definitely helped in bringing this website and the company out in the spotlight and get more coverage than most other height insole selling websites.

Personally, our website website here is intended to find a real valid method or technique to increase height for the individual who has already reached physical maturity and have their epiphyseal plates closed. This product offers a easy, simple, quick solution to help provide a person the extra confidence when they know that that they can look better from using the insoles. I do not endorse, promote, or sell any products related to the company. I just think the company is well received by the media, has a novel approach to height increase insoles, and is doing a good job in providing a nice product for people who wish to look taller.

I decided to post a Youtube video of the founder Derek White talking about his story up which I found from Youtube. The source link is from HERE


Dramatic Increase in Chinese Youths’ Average Height By 7 cm For Boys and 6 cm For Girls In 20 Years In 2002 News

Me: Somehow I stumbled upon this news of how the youth in China have increased by 6 cm in the last 20 years. What is amazing is that the news article was posted in 2002, 10 years ago. Going by that projection we can say that the youths’ height in the younger, up and coming generation of Chinese are probably 3 cms or a little over 1 inch taller than the youth we found in 2002, since we are now 10 years further along. It is easy to assume that along with economic increase and progress, the average height of a nation should increase. For the urban population in terms of males, they increased by 6.2 cm while for the females, they increased by 4.8 cm, both figures very impressive. However the numbers for the chinese youth in suburbs is even higher, at 7.5 cm increase and 6.1 cm increase for boys and girls, respectively.

We saw the same type of development in Japan and India with the correlation between increase in height and economic prosperity.

From a previous article I wrote, we saw that the youth of India in upper middle class young boys increased by about 4.5 cms in the last 15-20s years. At this current time, I don’t have the link to the old post, but it can be found in the archives if you really wanted to find the post I did.

The news link was taken from a Chinese news website link HERE

Last updated at: (Beijing Time) Wednesday, June 19, 2002

Dramatic Increase in Chinese Youths’ Average Height

Chinese youths’ average height rises 6cm as compared to that of 20 years ago, far exceeding the world average level. It is almost the same with that from 1960s to ’70s when Japan was experiencing a high economic development.
Chinese youths’ average height rises 6cm as compared to that of 20 years ago, far exceeding the world average level. It is almost the same with that from 1960s to ’70s when Japan was experiencing a high economic development. It is a conclusion of a survey conducted by the panel on health of Chinese students, after analyzing several items like height, weight and chest measurement of students aged from 7 to 17 scattered in 16 provinces from 1979 to 2000.The survey shows urban male and female students have put on a respective height of 6.2cm and 4.8cm over that in the last 20 years, suburban male and female students, an average of 7.5cm and 6.1cm.

According to the world average level youths put on height of 1cm and weight of 0.5kg every 10 years. Chinese youths have so to speak exceeded the standard level.

By PD Online Staff Yang Ruoqian

Youtube Discovery – Foot Stimulating Magnet Powered Height Increase Growth Machine Infomercial From China

Me: I somehow came across this infomercial on this device from China who is supposed to be able to stimulate growth and make people taller and increase height by somehow stimulating the feet using magnets and magnetic power. (Note: If we remember from elementary physics, the Magnetic force actually can do NO work so even the term of “magnetic power” is wrong since delB dot deld equals 0). The speaker of the video says that you attach the device to your feet somehow although the video never shows what it looks like. It seems to cost 1500 Chinese Yuan which converts to about $200 USD. I can save you some time right now so you don’t have to read any further on this infomercial product, it won’t work on physically mature adults. Move on, nothing to see here.

I don’t think I need to go into detail to justify or make sense the reason why I think this method of possibly increasing height is bogus. It reminds me a lot of the YOKO or KIMI height increase feet insole device we looked at in the beginning of this website. Magnetic technology and magnetic fields may have some way to possibly increase height and help grow taller but it has not been validated by any scientific research or PubMed studies, at least nothing which I have found in my searching so far. The fact that a height increase device is on an infomercial makes its credibility drop a lot, and the fact that it is sold in China makes it even less trustworthy.

I would guess that this device being sold is never intended for people who are already physically mature. The two people who are shown in the infomercial look really young, like teenagers so they probably still could grow if they really did use the device. There is not way to tell if their height increase is from natural genetics, food, and the normal growth process, or it is because of the device. This means that the validation of the device can never be proved wrong or right, but inconclusive.

In the video, we hear a guy who seems to have a British accent laugh at the informercial and talk down about it. He says at the end “if you believe that, you’ll believe anything”. It is possible that there might be real gullible people in China who are desperate enough to want to grow taller who will pick up that phone and dial to get this device.

This is a Youtube discovery found from this video link HERE


 

Increase Height And Grow Taller Using A Back Vertebrate Traction Device, Cervical, Lumbar, And Thoracic

In a recent previous post I had written about the possibility of increasing one’s height and to grow taller using a type of non-invasive spinal or vertebral decompression therapy. The post was “Increase Height And Grow Taller Through Non Surgical Spinal Decompression Using Spinal Decompression Therapy“. The therapy involved using a machine to pull in two opposite direction at the person’s upper torso and their hip area while the person was lying down horizontally. As a followup to that post, I would look at the different types of devices and equipment that I have found which can be used to achieve this type of height increase, since I had stated that there has been some evidence that the spinal decompression idea is effective.

Analysis & Interpretation:

The types of traction devices I’ve found from say Amazon seem to show that the devices don’t really do much for bone. The device seems to be used mainly for massaging and stretching out muscles which would mean that the bones don’t get much realignment, which is where the real height increase would come from. There is two types of traction devices, one for the cervical or neck region and the other for the lower back. From a quick search it would seem that the devices that is sold more are the neck traction devices. This might mean that the height increase may be only possible if the curvature of the back is coming from the top vertebrate portion. As for it’s effectiveness, I would say that one can only see any real height increase if the devices can realign bone. The flat horizontal tables which allow for torso stretching would have the best chance to work.


From the Amazon website HERE we find a few types of traction devices being sold,

1. NEW Model Comfortract Home Cervical Traction Unit 

by LGMedSupply

Screen Shot 2013-02-14 at 11.47.18 PM

The ComforTrac Cervical Traction Device is the best traction unit currently available on the market!Therapists have overwhelmingly selected the ComforTrac home traction devices over any other device on the market. The ComforTrac Cervical Traction Device is designed to offer treatment and management of acute and chronic pain. Revolutionary neck wedges provide optimal suboccipital contact for patient comfort, thus eliminating the compression of the TMJ. ComforTrac is far superior to over-the door traction methods.

 

 

2. Instapark® CNT-C Cervical Neck Traction

traction4Description: * This Soft Air-pressure Neck Traction is very comfortable and easy to use for Pain Relief. It elongates neck muscles and separates cervical vertebrae, often resulting in rapid and prolonged relief from the soreness and irritation that accompanies cervical problems. * Gentle, intermittant traction exercises the neck muscles increasing circulation. * Firm, static traction lowers the pressure between vertebrae, freeing pinched nerves and easing herniated discs. * It improves blood supply to neck muscles,tendons, and ligaments. * Three layers Prevent, control and diminish painful neck and shoulder aches and pains with this comfortable, inflatable neck traction therapy. * This Cervical Traction is designed to maintain the natural curve and alignment of the neck for your health. * During traction therapy it gently elongates neck muscles and separates cervical vertebrae, often resulting in rapid and prolonged relief from the soreness and irritation that accompanies cervical problems. * Easy to use, comfortable and non-threatening.

 

 

3. Pronex Pneumatic Cervical Traction Device by RS Medical
traction5Pronex® Pneumaticl Cervical Traction Device Large Maintains the natural curve and alignment of the neck Easy to use, comfortable and non-threatening Reduces the need for costly pain medication

 

 

 

 


From RehabOutlet.com HERE

1. Cervical Traction/ Neck Traction (Saunders Cervical Hometrac)

traction1

New Innovative Design
  • Built-in angle adjustment
  • Enhanced patient comfort features that include softer, more comfortable head strap and head pad
  • Attractive carrying case included
  • No assembly required

 

 

 

2. Supine C-Trax™ Cervical Traction Device

traction3

The innovative Supine C-Trax™ is a physical therapist-designed cervical traction system for optimal supine positioning and comfortable intermittent traction force. Using any door frame, the Supine C-Trax™ is quickly and easily set up; positioning into cervical flexion or extension is also as effortless. Furthermore, the one-of-a-kind intermittent traction attachment allows the clinician a choice of intermittent or static distraction. To securely hold the cervical halter, the uniquely designed spreader bar eliminates the common problem of slippage. Also standard with the Supine C-Trax™ is a 20lb (9kg) water weight bag. Can help alleviate Neck Pain

 

 

3. Saunders Lumbar Hometrac Traction

Saunders Lumbar Traction Provides High-Quality Treatment That Replicates Clinical Traction!

  • The patient is held secure by comfortable thoracic and pelvic belts. Most users can position themselves without help.
  • Patented pump incorporates an easy “click into place” mechanism for pumping, sustaining, and releasing the traction—it’s easy to use and eliminates air leaks.
  • Gauge is calibrated in lbs/kgs to provide feedback and promote consistency in treatment.

traction2